Results 71 to 80 of about 760,056 (268)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Primenjena PsihologijaIntroduction: The role of neuroticism in the relationship between nightmare characteristics (e.g., frequency and replicativity), and nightmare-related suffering, i.e., nightmare-related distress and impairment after awaking, is still to be explored ...
Sonja Protić +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
«Фауст» в этномузыкальном контексте: «По ту сторону Тулы» А. Николева
Вестник музыкальной науки, 2016 Рассматривается роман ученого-классика. Роман связан со всеми компонентами музыкальной формы: структурой, динамикой, мелодикой, гармонией. В фольклоре конца 1920-х гг.
Васильева, Галина Михайловна
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Ivan Denisovich (SCH-845) psychological survival code
Консультативная психология и психотерапия, 2013 The paper provides an analysis of how a person experiences and overcomes critical life situations. The process of overcoming is explored by means of joining Aleksandr Solzhenitsyn's experimental psychological laboratory described in his novel One Day in ...
Pergamenshchik L.A.
doaj
Like a Fly against a Pane of Glass: Simone Weil in the Context of Contemporary Theories of Suffering
Labyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, 2023 The last five years have seen a welcome rise in philosophical research on suffering. In this paper I will introduce the main new proposals and point out their respective weak-nesses.
Eva-Maria Düringer
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Suffering and Punishment [PDF]
, 2020 This paper offers a defence of the Communicative Theory of Punishment against recent criticisms due to Matt Matravers. According to the Communicative Theory, the intentional imposition of suffering by the judiciary is justified because it is intrinsic to the condemnation and censure that an offender deserves as a result of wrongdoing.
openaire +1 more source