Results 61 to 70 of about 2,407,462 (283)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Relations and Moral Obligations towards Other Animals
Relations, 2015 Relational accounts acknowledge and emphasise the intersubjective nature of selfhood and argue that focusing solely on the capacities of animals cannot account for all moral obligations towards them.
Beril Sözmen
doaj +1 more source
Specular suffering: (staging) the body in pain [PDF]
, 2008 For the abstract see the PDF ...
Richards, M
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Erinys’ Mortal Venom: The Poetic Expression of Emotions in Silius Italicus’ "Punica" (Books I–V)
Classica Cracoviensia, 2018 Erinys’ Mortal Venom: The Poetic Expression of Emotions in Silius Italicus’ "Punica" (Books I–V) Negative emotions are used to construct and develop the plot in the first five books of Silius Italicus’ Punica. Dark, irrational forces, i.e.
Stanisław Śnieżewski
doaj +1 more source
Serum beta-glucuronidase determination in normal subjects and in neurological and mental patients, a provisional report [PDF]
, 1963 Using the method given by GOLDSTEIN (1961)9 for the determination of serum beta-glucuronidase activity, this value was determined in both normal and patients with epilepsy, neuroses, psychoses and multiple sclerosis.
Plum, Claus Munk
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Revista Crítica de Ciências Sociais, 2018 This article analyses some of the emerging problems in the field of social studies at the juncture of the domains of health and science. Building on critical perspectives, namely those hailing from social history, postcolonial studies and collaborative ...
Tiago Pires Marques
doaj +1 more source
One Big Thing: Suffering as the Path to New Life in Crime and Punishment [PDF]
, 2015 After spending a whole semester reading and thinking about Dostoevsky, the main thing that has struck me about him is his treatment of the theme of suffering.
Kramer, Kelly M
core +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source