Results 61 to 70 of about 2,404,149 (283)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Erinys’ Mortal Venom: The Poetic Expression of Emotions in Silius Italicus’ "Punica" (Books I–V)

open access: yesClassica Cracoviensia, 2018
Erinys’ Mortal Venom: The Poetic Expression of Emotions in Silius Italicus’ "Punica" (Books I–V) Negative emotions are used to construct and develop the plot in the first five books of Silius Italicus’ Punica. Dark, irrational forces, i.e.
Stanisław Śnieżewski
doaj   +1 more source

Specular suffering: (staging) the body in pain [PDF]

open access: yes, 2008
For the abstract see the PDF ...
Richards, M
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Illness and the Politics of Social Suffering: Towards a Critical Research Agenda in Health and Science Studies

open access: yesRevista Crítica de Ciências Sociais, 2018
This article analyses some of the emerging problems in the field of social studies at the juncture of the domains of health and science. Building on critical perspectives, namely those hailing from social history, postcolonial studies and collaborative ...
Tiago Pires Marques
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

Prevalence and characteristics of tinnitus after leisure noise exposure in young adults [PDF]

open access: yes, 2014
The main goal of this study was to assess the prevalence and characteristics of tinnitus among students after exposure to leisure noise. In addition, the effects of tinnitus on otoacoustic emissions (OAEs) in participants suffering from chronic tinnitus ...
Corthals, Paul   +3 more
core   +3 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Marie Uguay et Saint-Denys Garneau, au bord du vide

open access: yesConserveries Mémorielles, 2010
This is a comparative analysis of the works of two Quebecois poets, Saint-Denys Garneau and Marie Uguay who have many common points.  Both express a conscience and a lucid vision of death. Their poetic works show that their lyric subjects are situated in
Mylène Durand
doaj  

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