Results 71 to 80 of about 5,211,856 (273)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Information preserving sufficient summaries for dimension reduction
Journal of Multivariate Analysis, 2013 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
David Nelson, Siamak Noorbaloochi
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Dimension reduction using global and local pattern information-based maximum margin criterion
, 2016 Dimension reduction is an important research area in pattern recognition when dealing with high-dimensional data. In this paper, a novel supervised dimension reduction approach is introduced for classification. Advantages of using not only global pattern
Sakarya, Ufuk
core +1 more source
Adaptive Reduction of Curse of Dimensionality in Nonparametric Instrumental Variable Estimation
MathematicsNonparametric estimation of instrumental variable treatment effects typically builds on various nonparametric identification results. However, these estimators often face challenges from the curse of dimensionality in practice, as multi-dimensional ...
Ming-Yueh Huang, Kwun Chuen Gary Chan
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
PLoS ONE, 2014 CRC cancer is one of the deadliest diseases in Western countries. In order to develop prognostic biomarkers for CRC (colorectal cancer) aggressiveness, we analyzed retrospectively 267 CRC patients via a novel, multidimensional biomarker platform.
Marisa Mariani +9 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
LDR: A Package for Likelihood-Based Sufficient Dimension Reduction [PDF]
We introduce a new mlab software package that implements several recently proposed likelihood-based methods for sufficient dimension reduction. Current capabilities include estimation of reduced subspaces with a fixed dimension d, as well as estimation ...
R. Dennis Cook +2 more
core
Robust estimation of dimension reduction space [PDF]
Most dimension reduction methods based on nonparametric smoothing are highly sensitive to outliers and to data coming from heavy-tailed distributions. We show that the recently proposed methods by Xia et al.
Wolfgang Härdle, Pavel Cizek
core +2 more sources