Results 61 to 70 of about 5,211,856 (273)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Nonlinear Sufficient Dimension Reduction with a Stochastic Neural Network [PDF]
, 2022 Sufficient dimension reduction is a powerful tool to extract core information hidden in the high-dimensional data and has potentially many important applications in machine learning tasks.
Liang, Siqi, Liang, Faming, Sun, Yan
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Alternating Direction Method of Multipliers for Sufficient Dimension Reduction
Journal of MathematicsThe minimum average variance estimation (MAVE) method has proven to be an effective approach to sufficient dimension reduction. In this study, we apply the computationally efficient optimization algorithm named alternating direction method of multipliers
Sheng Ma, Qin Jiang, Zaiqiang Ku
doaj +1 more source
Impact of informational dimension and information on the operation cost [PDF]
Војно дело, 2014 Despite the disappearance of the bipolar world, the mankind has not yet become free from challenges, risks and threats to peace and security. Armed conflicts have remained a part of reality, and new security challenges, risks and threats have emerged ...
Miladinović Mića, Šipka Branko
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
LDR: A Package for Likelihood-Based Sufficient Dimension Reduction
Journal of Statistical Software, 2011 We introduce a new mlab software package that implements several recently proposed likelihood-based methods for sufficient dimension reduction. Current capabilities include estimation of reduced subspaces with a fixed dimension d, as well as estimation ...
R. Dennis Cook +2 more
doaj
Optimal control theory for a unitary operation under dissipative evolution
New Journal of Physics, 2014 We show that optimizing a quantum gate for an open quantum system requires the time evolution of only three states irrespective of the dimension of Hilbert space. This represents a significant reduction in computational resources compared to the complete
Michael H Goerz +2 more
doaj +1 more source