Results 81 to 90 of about 535,131 (310)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks   +10 more
wiley   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang   +10 more
wiley   +1 more source

Closing the Yield Gap of Sugar Beet in the Netherlands—A Joint Effort

open access: yesFrontiers in Plant Science, 2018
The reform of the European Union's sugar regime caused potential decreasing beet prices. Therefore, the Speeding Up Sugar Yield (SUSY) project was initiated.
Bram Hanse   +3 more
doaj   +1 more source

Productivity Progress in Sugar Beet Production - With Special Emphasis on the Contribution of Breeding [PDF]

open access: yes
Sugar beet production during the past 50 years has been characterised by remarkable progress in productivity. In this contribution the influence of the different production factors on productivity and value added growth is analysed by regarding input and
Zeddies, Jurgen, Zimmermann, Beate
core   +1 more source

Dietary molasses enhances ruminal biohydrogenation and partially alleviates diet- induced milk fat depression [PDF]

open access: yes, 2008
Dairy Research, 2008 is known as Dairy Day, 2008Milk fat depression remains a problem on dairy farms, and in recent years, incorporation of distillers grains (typically with solubles added and often dried) has contributed to this problem on some farms.
Bradford, Barry J., Titgemeyer, Evan C.
core   +2 more sources

Impact of Positive Lifestyle Behaviors on Direct Health Care Cost Savings for Low Back Pain

open access: yesArthritis Care &Research, EarlyView.
Objective This study aimed to investigate the relationship between a previously purpose‐developed lifestyle behavior scale and health care cost savings related to low back pain (LBP). Methods This longitudinal study used data from the Australian Twin Back (AUTBACK) study. LBP and lifestyle behavior measures were collected at baseline. Physical activity
Ye Tian   +8 more
wiley   +1 more source

Assessment of Stability and Adaptation Patterns of White Sugar Yield from Sugar Beet Cultivars in Temperate Climate Environments

open access: yesAgronomy, 2019
The yield and yield quality of sugar from the sugar beet (Beta vulgaris L.) and are determined by genotype, environment and crop management. This study was aimed at analyzing the stability of white sugar yield and the adaptation of cultivars based on 36 ...
Marcin Studnicki   +4 more
doaj   +1 more source

Associations of Sleep and Shift Work with Osteoarthritis Risk

open access: yesArthritis Care &Research, Accepted Article.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships between circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000‐person cohort, we evaluated associations between sleep duration, sleeplessness/insomnia, and ...
Elizabeth L. Yanik   +5 more
wiley   +1 more source

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