Results 171 to 180 of about 1,868,532 (217)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Female moths incorporate plant acoustic emissions into their oviposition decision-making process. [PDF]

Elife
Seltzer R, Zer Eshel G, Yinon O, Afani A, Eitan O, Matveev S, Levedev G, Davidovitz M, Ben Tov T, Sharabi G, Shapira Y, Shvil N, Harari Gibli M, Atallah I, Hadad S, Ment D, Hadany L, Yovel Y.   +17 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Response to the letter to the editor: Appraisal of suspicious for malignancy cytology: nuclear characteristics deserve special attention in reported cytology analysis - real-world scenario cohort in thyroidology. [PDF]

Arch Endocrinol Metab
Macedo FC, Delfim RLC, Vaisman F.
europepmc   +1 more source

In-hospital survival and predictors of mortality among stroke patients at a tertiary hospital in Ghana: A retrospective cohort study. [PDF]

PLoS One
Abdulai SB, Karikari JK, Tembo P, Habumugisha T, Tembo W, Cobbinah AI, Enuameh Y.   +6 more
europepmc   +1 more source

Protocol for evaluation of Movember's scaling what works grant funding program: Supporting the delivery of mental health interventions for men & boys in Australia, Canada and the United Kingdom. [PDF]

PLoS One
Steele T, Ang C, Rose V, Kembhavi G, Rowland J, Abdo M, Kwok J, Young K, Merryfull S, Whittaker S, Brusco N, Watt R, Büsst C.   +12 more
europepmc   +1 more source

Optimizing Order Sets With a Large Language Model-Powered Multiagent System.

JAMA Netw Open
Liu S, Huang SS, McCoy AB, Wright AP, Horst S, Wright A.   +5 more
europepmc   +1 more source

Response to the letter to the Editor entitled "Heat Stress and Contaminated Hydration; A Dual-Edged Role in CKD of Uncertain Etiology". [PDF]

Kidney Int Rep
Biswas P, Sahu AK, Shristi S, Baitharu I.   +3 more
europepmc   +1 more source

Efficacy and Safety Comparison of Ulinastatin versus Flurbiprofen Axetil for Preemptive Analgesia in Reducing Opioid Burden After Total Knee Arthroplasty: A Randomized Controlled Trial [Response to Letter]. [PDF]

J Pain Res
Wang D, Li Y.
europepmc   +1 more source