Results 101 to 110 of about 263,965 (231)

Substitution of CH3 by CH2F in 2‐Methylerythritol Cyclodiphosphate Triggers Potent Inhibition of IspG with Concomitant Fluoride Ion Expulsion

open access: yesChemistry – A European Journal, EarlyView.
The fluoromethyl analogue of MEcPP was identified as a very potent inhibitor of the oxygen‐sensitive [4Fe‐4S] metalloenzyme IspG. In the course of the IspG‐catalyzed transformation, this novel compound undergoes fluoride elimination, offering additional evidence for the involvement of a carbanionic intermediate in the mechanism of this enzyme ...
Clea Witjaksono   +7 more
wiley   +1 more source

Report for Cooperation and Working Together of the Ireland North South urban rural epidemiological study of suicidal behaviour. [PDF]

open access: yes, 2006
The prevention of suicide and suicide attempts remains a challenge for clinicians in Health Care provision. Suicide and attempted suicide (now usually termed “deliberate self-harm” or “self-harm” in the United Kingdom) are major problems in most ...

core  

Sexual Minority Stress and Suicide Risk: Identifying Resilience through Personality Profile Analysis [PDF]

open access: yes, 2015
Sexual minority-based victimization, which includes threats or enacted interpersonal violence, predicts elevated suicide risk among sexual minority individuals.
Cochran, Bryan N.   +5 more
core   +2 more sources

Computational Insights into the Structural Basis for Reduced Hepatotoxicity of Novel Nonopioid Analgesics

open access: yesChemMedChem, EarlyView.
Docking and molecular dynamics simulations within CYP2E1 clarify the structural basis for the reduced hepatotoxicity of novel non‐opioid analgesics developed as safer alternatives to acetaminophen. The results reveal that hydrophobicity and substituent size critically influence binding conformations, thereby modulating toxicity.
Claire Coderch   +5 more
wiley   +1 more source

Psychiatric disorder, traumatic experience and social deprivation in distinct subtypes of suicide attempt: a cross-national study using latent class analysis

open access: yesBMC Public Health
Background Suicide attempts are critical predictors of suicide. Developing typologies of suicide attempt may indicate new prevention strategies, which have not been investigated by comparing developed and developing countries.
Xia-Can Chen   +7 more
doaj   +1 more source

Neuroeconomics of suicide. [PDF]

open access: yes, 2011
Suicidal behavior is a leading cause of injury and death worldwide. Suicide has been associated with psychiatric illnesses such as depression and schizophrenia, as well as economic uncertainty, and social/cultural factors.
Takahashi, Ph.D Taiki
core   +2 more sources

Attempted suicide and pregnancy

open access: yesJournal of Injury and Violence Research, 2011
The aim of the Budapest Monitoring System of Self-Poisoning Pregnant Women was to evaluate the potential congenital abnormality inducing effect of extremely large doses of drugs among pregnant women who attempted suicide. This system was appropriate to describe the characteristics of these pregnant women as a secondary finding from this model.All self ...
openaire   +4 more sources

Effects of Ambient and Display Lighting Color on Risk‐Taking Behavior, Perceived Emotional States, and Visual Quality of Indoor Environment

open access: yesColor Research &Application, EarlyView.
In a digital risk‐taking test, participants inflated a balloon to increase earned points at the risk of popping under different display and ambient lighting conditions. ABSTRACT Lighting from architectural fixtures and screens can have impacts beyond visual perception, such as occupants' cognitive functions and emotional states. Despite the ubiquity of
Naser Shehab, Dorukalp Durmus
wiley   +1 more source

Factors Related to Suicide Attempts by Poisoning in Iranian Children [PDF]

open access: yes
Objective: Suicide is a major health problem especially in children. Even a large proportion of healthy children have thought about suicide attempt. Some factors are suggested as risk factors for suicide attempt among children such as prior suicide ...
ثقه الاسلام, طاهره   +4 more
core  

Mental defeat is associated with suicide intent in patients with chronic pain [PDF]

open access: yes, 2016
Objective: Mental defeat has been implicated in precipitating suicide with effects not explained by depression. It has also been found to be elevated in people who are most distressed and disabled by chronic pain.
Ashworth, Polly   +2 more
core   +1 more source

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