Results 91 to 100 of about 1,019,815 (357)

Tackling social disconnection: an umbrella review of RCT-based interventions targeting social isolation and loneliness

BMC Public Health
Background Social isolation and loneliness are urgent public health concerns associated with negative physical and mental health outcomes. Understanding effective remedies is crucial in addressing these problems.
Thomas Hansen, Ragnhild Bang Nes, Kamila Hynek, Thomas Sevenius Nilsen, Anne Reneflot, Kim Stene-Larsen, Ragnhild Agathe Tornes, Julia Bidonde   +7 more
doaj   +1 more source

The impact of borderline personality disorder and sub-threshold borderline personality disorder on the course of self-reported and clinician-rated depression in self-harming adolescents

Borderline Personality Disorder and Emotion Dysregulation, 2017
Background Studies on adults suggest that the presence of comorbid depression and Borderline Personality Disorder (BPD) is associated with an elevated risk of self-harming behaviours and that self-harming behaviours, when present, will have higher ...
Ruth-Kari Ramleth, Berit Groholt, Lien M. Diep, Fredrik A. Walby, Lars Mehlum   +4 more
doaj   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Mixed-methods psychosocial autopsy study of suicide in young and middle-aged individuals in the Netherlands

BMJ Public Health
Introduction Sociodemographic characteristics of suicide decedents are recorded in the Netherlands, through which we know who died by suicide, but not why.
Renske Gilissen, Merijn Eikelenboom, Arne Popma, Elias Balt, Saskia Mérelle, Stefan Vrinzen, Amra Žerić, Dewi Wiggers, Daan Creemers   +8 more
doaj   +1 more source

Mediating Effects of Positive Thinking and Social Support on Suicide Resilience [PDF]

, 2018
Suicide has been the second leading cause of death for 18- to 24-year-olds in the United States since 2011. The stress experienced by undergraduate college students has the potential to increase one’s risk for suicide.
Bekhet, Abir K., Garnier-Villarreal, Mauricio, Matel-Anderson, Denise M.   +2 more
core   +1 more source

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, EarlyView.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

Paraquat at 63—the story of a controversial herbicide and its regulations: It is time to put people and public health first when regulating paraquat

BMC Public Health
Background Paraquat is one of the most widely used herbicides in the world, despite its high human toxicity and the overwhelming evidence of associated high morbidity and mortality. Due to the significant public health implications of the use of paraquat,
Leah Utyasheva, Prabath Amarasinghe, Michael Eddleston   +2 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Geospatial estimates of suicidal ideation and suicide attempt prevalence in the U.S. veteran population (2022)

Injury Epidemiology
Background Veteran suicide remains a major public health concern; rates increased 64.3% from 2001 to 2022 and substantial geospatial variation exists, with state-level rates ranging from 15.4/100,000 (Maryland) to 87.1/100,000 (Montana).
Julie A. Kittel, Lindsey L. Monteith, Ryan Holliday, Theresa T. Morano, Alexandra L. Schneider, Lisa A. Brenner, Claire A. Hoffmire   +6 more
doaj   +1 more source