Results 31 to 40 of about 320,187 (315)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Forecasting call and chat volumes at online helplines for mental health

BMC Public Health, 2023
Background Each year, many help seekers in need contact health helplines for mental support. It is crucial that they receive support immediately, and that waiting times are minimal. In order to minimize delay, helplines must have adequate staffing levels,
Tim Rens de Boer, Saskia Mérelle, Sandjai Bhulai, Renske Gilissen, Rob van der Mei   +4 more
doaj   +1 more source

Suicide Among Adolescents in Center Tunisia: An 18-Year Autopsy Study [PDF]

, 2016
Background: Suicide and suicide attempts are more common among adolescents. Many factors are known to influence suicide in particular: region and culture.
Jedidi M, Mlayeh S, Hamila I, Masmoudi T, Ben Dhiab M, Zemni M, Souguir MK   +6 more
core   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

The prevalence, course, and risk factors of suicidal ideation and suicide attempts among students in vocational education

Child and Adolescent Psychiatry and Mental Health
Background Worldwide, suicide is one of the leading causes of death among adolescents and young adults. Given that suicide in this age group is common within vocational students, this study aims to provide insights into the prevalence, course, and risk ...
Milou Looijmans, Paula von Spreckelsen, Guus Berkelmans, Arne Popma, Diana van Bergen, Renske Gilissen, Saskia Mérelle   +6 more
doaj   +1 more source

Comparison of Characteristics of Suicide Attempts Registered in Urban and Rural Areas in China

Frontiers in Psychiatry, 2022
Objective: The objective of this study is to compare the characteristics of suicide attempts registered in general hospitals in urban and rural areas in China.Methods: From January 2007 to December 2011, suicide attempts registered in hospitals in five ...
Lingling Li, Lingling Li, Lingling Li, Chunxu Liu, Yongsheng Tong, Yongsheng Tong, Yongsheng Tong, Jianlan Wu, Jianlan Wu, Jianlan Wu, Wei Zhou, Wei Zhou, Yi Yin, Yi Yin, Yi Yin, Mengjie Wu, Mengjie Wu, Mengjie Wu, Ruoyang Tong, Jing An, Jing An   +20 more
doaj   +1 more source

Suicide in New South Wales: the NSW suicide data report. [PDF]

, 2001
The NSW Suicide Prevention Strategy has identified suicide prevention as a high priority for government and the community. Death by suicide is a relatively uncommon event; however, more people in NSW now die from suicide than road injury. Nationally, two
Ansari, Guncha, Chipps, Jennifer, Stewart, Gavin   +2 more
core   +2 more sources

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Preventing Suicide in Prisons, Part I Recommendations fromthe International Association for Suicide Prevention Task Force on Suicide in Prisons [PDF]

, 2007
. In 2000 the Department of Mental Health of the World Health Organization (WHO) published a guide named Preventing Suicide. A Resource for Prison Officers as part of the WHO worldwide initiative for the prevention of suicide.
Daigle, M.S., Daniel, A.E., Dear, G.E., Frottier, P., Hayes, L.M., Kerkhof, A.J.F.M., Konrad, N., Liebling, A., Sarchiapone, M.   +8 more
core   +2 more sources

Cognitive Behavioral Therapy for Youth With Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐Onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source