Results 31 to 40 of about 83,910 (267)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Suicide after contact with substance misuse services: a national registry study

BJPsych Open, 2020
BackgroundPeople with substance use disorders have a well-known increased risk for taking their own life. Previous research has mainly focused on suicide in mental health services, whereas there is limited knowledge regarding suicide after contact with ...
Martin Ø. Myhre, Anine T. Kildahl, Fredrik A. Walby   +2 more
doaj   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Treating suicidality remotely (TREASURE): study protocol for a remote randomized controlled trial comparing personalized cognitive behavioral therapy for suicide prevention with a guided self-help course in adolescents and adults

Trials
Background Practical and psychological barriers make it difficult for people with Suicidal Thoughts and Behaviors (STBs) to obtain professional help. Remote interventions have the potential to overcome many of these barriers, but the remote interventions
Wilco Janssen, Saskia Mérelle, Renske Gilissen, Claudi Bockting   +3 more
doaj   +1 more source

The psychosocial toll of Dublin III on asylum seekers in the Netherlands

American Journal of Community Psychology, EarlyView.
Abstract The Dublin III Regulation determines which EU Member State is responsible for examining asylum claims, but its implementation carries significant consequences for those subjected to it. This study examines how Dublin III, as implemented in the Netherlands, affects asylum seekers' psychosocial wellbeing using Silove′s Adaptation and Development
Imen El Amouri
wiley   +1 more source

Comparison of Characteristics of Suicide Attempts Registered in Urban and Rural Areas in China

Frontiers in Psychiatry, 2022
Objective: The objective of this study is to compare the characteristics of suicide attempts registered in general hospitals in urban and rural areas in China.Methods: From January 2007 to December 2011, suicide attempts registered in hospitals in five ...
Lingling Li, Lingling Li, Lingling Li, Chunxu Liu, Yongsheng Tong, Yongsheng Tong, Yongsheng Tong, Jianlan Wu, Jianlan Wu, Jianlan Wu, Wei Zhou, Wei Zhou, Yi Yin, Yi Yin, Yi Yin, Mengjie Wu, Mengjie Wu, Mengjie Wu, Ruoyang Tong, Jing An, Jing An   +20 more
doaj   +1 more source

Using photovoice to understand community perceptions of firearm risks and protective factors among Asian Americans

American Journal of Community Psychology, EarlyView.
Abstract This study used photovoice methodology to explore Asian Americans' perspectives on the root causes and protective factors of firearm violence in their communities. Photovoice provided a participatory platform for community members to document lived experiences and identify priorities for change.
Tsu‐Yin Wu, Szu‐Hsien Chen, Xining Yang, Ken Resnicow, Hsing‐Fang Hsieh   +4 more
wiley   +1 more source

Impact of Systematic Tailored Assessment for Responding to Suicidality (STARS) Protocol Training on Mental Health Professionals' Attitudes, Perceived Capabilities, Knowledge, and Reluctance to Intervene

Frontiers in Psychiatry, 2022
Background and AimsSystematic Tailored Assessment for Responding to Suicidality (STARS) protocol and associated training were developed with the key objectives of supporting clinicians to conduct a suicide enquiry, obtaining a comprehensive account of ...
Jacinta Hawgood, Tamara Ownsworth, Kairi Kõlves, Susan H. Spence, Ella Arensman, Ella Arensman, Ella Arensman, Diego De Leo   +7 more
doaj   +1 more source

Vision Zero in Suicide Prevention and Suicide Preventive Methods

, 2022
AbstractAccording to the World Health Organization (WHO), suicide is a global public health issue, and countries need to be working toward a comprehensive and holistic response to prevent suicide and suicidal behaviors. Vision Zero for suicide is an aspiring goal that aims to lower suicide occurrence through a combined action of public health and ...
D. Wasserman, I. Tadić, C. Bec
openaire   +1 more source

B/ordering and healthcare access for migrants with precarious status: The role of healthcare workers in counteracting restrictive policies

American Journal of Community Psychology, EarlyView.
Abstract In Canada, precarious migration is largely invisibilized. Nonetheless, b/ordering greatly affects people's realities by limiting access to social rights. In Quebec, migrants with precarious status (MPS) do not have access to healthcare, although Quebec has a “universal” healthcare coverage.
Émilie Pigeon‐Gagné, Jill Hanley, Élise Bourgeois‐Guérin, Pénélope Boudreault   +3 more
wiley   +1 more source