Results 61 to 70 of about 320,187 (315)

Suicide Prevention & Response: A Comprehensive Resource Guide for Indiana Schools 2018 [PDF]

, 2018
Document created for the Indiana Department of Education for Suicide Prevention and ...
Gerdt, Laurie, Oliver, Brandie M.
core   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Paraquat at 63—the story of a controversial herbicide and its regulations: It is time to put people and public health first when regulating paraquat

BMC Public Health
Background Paraquat is one of the most widely used herbicides in the world, despite its high human toxicity and the overwhelming evidence of associated high morbidity and mortality. Due to the significant public health implications of the use of paraquat,
Leah Utyasheva, Prabath Amarasinghe, Michael Eddleston   +2 more
doaj   +1 more source

Needs Assessment of Suicide Prevention in Vermont Middle and High Schools [PDF]

, 2018
Introduction. Adolescent suicide is epidemic. 17% of high school students con- sidered suicide and 8% attempting to take their lives in 2015 nationwide.
Chawla, Rajan, Earle, William, Fontaine, Kristin, Goldberg, Eli, Griffin, Mary, Jemison, Jill, Kardys, Amanda, Moring, Nikolas, Schoen, Elias, Vayda, Emily   +9 more
core   +1 more source

A Markov chain model for studying suicide dynamics: an illustration of the Rose theorem [PDF]

, 2014
Background: High-risk strategies would only have a modest effect on suicide prevention within a population. It is best to incorporate both high-risk and population-based strategies to prevent suicide.
Kawachi, Ichiro, So, Bing Kwan, Yip, Paul Siu Fai, Zhang, Yi   +3 more
core   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Insights into Men's Suicide [PDF]

, 2012
Suicide is a considerable public health issue garnering increasing attention in public and academic dialogue over the past few years. Despite alarming statistics showing a high gender skewing towards males, there has been remarkably little focus on ...
Beaton, S.J., Forster, Peter
core   +1 more source

La suicidologie, un outil de gestion du comportement [PDF]

, 2007
S’appuyant sur des documents sociohistoriques et des rapports technico-administratifs produits par une organisation appelée la suicidologie, l’auteure se propose de montrer ce qu’est aujourd’hui un centre de prévention-modèle québécois et comment se ...
Aujard, Marie-France
core   +1 more source

Genetic Code Expanded T Cell for Controllable Immunotherapy

Advanced Science, EarlyView.
Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
wiley   +1 more source

A community‐driven approach to address substance use and create a Great Plains American Indian addiction and recovery research agenda

American Journal of Community Psychology, EarlyView.
Abstract Substance use, specifically opioid and methamphetamine use, is of increasing concern among American Indian (AI) populations in the Great Plains. This community‐driven participatory study investigated the impacts of substance use and community‐defined needs in treating addiction.
Brynn Luger, Anna Kihlström, Brinda Sivaramakrishnan, Allison Kelliher, Frankie Kropp, Carmen Rosa, T. John Winhusen, Donald Warne, the CTN0129 participating Tribal communities   +8 more
wiley   +1 more source