Results 111 to 120 of about 15,357,394 (325)
IBM PC/IX operating system evaluation plan [PDF]
An evaluation plan for the IBM PC/IX Operating System designed for IBM PC/XT computers is discussed. The evaluation plan covers the areas of performance measurement and evaluation, software facilities available, man-machine interface considerations ...
Dominick, Wayne D. +3 more
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Frontiers in Environmental ScienceThe Production-Living-Ecological Space (PLES) serve as a crucial link for regional sustainable development, making the study of their development suitability of significant importance.
Dongchang Liu, Aruhan, Aruhan, Sai Na
doaj +1 more source
Site suitability evaluation for bivalve mariculture in Maharashtra [PDF]
, 2016 The coastal stretch of Konkan Maharashtra is endowed with large number of west flowing rivers forming productive estuaries and creeks fringed by mangrove vegetation.
Asokan, P K +2 more
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Frontiers in Marine ScienceThe Pacific oyster (Crassostrea gigas) is a marine aquaculture species with rapid production growth in recent years. China accounts for nearly 90% of global production by 2021, especially in Shandong province.
Chunlin Li +5 more
doaj +1 more source
Land Use Scanner: the continuous cycle of application, evaluation and amelioration in landuse modelling [PDF]
The Land Use Scanner is a logit model that simulates future land use in a GIS environment. The model uses claims from sectoral models as input, next to physical suitability, distance decay and policy maps.
Borsboom, Judith +2 more
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Strategies for evaluation of suitable donors: Italian experience.
Annals of transplantation, 2004 Italy was lacking standardised procedures for donor safety evaluation. We developed practice guidelines, while a panel of experts coordinated by the National Transplant Centre, is available 24 hours a day to support decisions in difficult cases. The guidelines identify five levels of risk and give recommendations for the utilization of donors with HBV ...
S. Venettoni +10 more
openaire +3 more sources