Results 41 to 50 of about 164,018 (269)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Agronomy, 2022 Suitability evaluation of tea cultivation is very important for improving the yield and quality of tea, which can avoid blind expansion and achieve sustainable development; however, to date, relevant research at town and village scales is lacking.
Wenwen Xing +7 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Frontiers in Environmental ScienceWith a large population and rapid urbanization, there are still many challenges to optimize the ecological-agricultural-urban space. Here, taking Yulin City, situated on the Loess Plateau of China as a case in point, we explored the spatial suitability ...
Anqi Li +8 more
doaj +1 more source
Suitability Evaluation of the Lining Form Based on Combination Weighting–Set Pair Analysis
Applied Sciences, 2022 Aiming at the many uncertain factors in the suitability evaluation of reinforced concrete lining of high-pressure pipelines, the set pair analysis (SPA) theory is used to establish the suitability evaluation model.
Chen Xing +3 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Shuiwen dizhi gongcheng dizhiCarbon dioxide (CO2) geological storage is one of the most direct and effective measures to alleviate the greenhouse effect under the current technical conditions. Deep saline aquifers and cap beds are widely distributed in Lindian, Heilongjiang Province,
Yongfa MA +13 more
doaj +1 more source
Atmosphere, 2023 This study is the first to propose the deployment of direct air capture (DAC) systems at large airports to provide solutions for achieving carbon neutrality in aviation transportation.
Feiyin Wang +5 more
doaj +1 more source