Results 81 to 90 of about 15,357,394 (325)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Evaluation of the Suitability of Street Vending Planning in Urban Public Space in the Post-COVID-19 Era

Land
The COVID-19 pandemic has spurred the resurgence of the informal street vending economy. This revival has boosted the market economy but has also challenged urban governance. Recognizing street vending deregulation as both a stimulus for employment and a
Xiaosi Zhang, Jizhong Shao
doaj   +1 more source

A Feasibility Analysis of Applying Water Quality Trading [PDF]

, 2005
Water quality trading is a policy tool that could improve the cost-effectiveness of achieving environmental goals, but it is not currently used in the state of Georgia.
Kristin Rowles
core  

SITE SUITABILITY EVALUATION FOR ECOTOURISM DEVELOPMENT: A CASE STUDY IN BULUE VILLAGE, SOPPENG DISTRICT, INDONESIA

Journal of sustainability science and management, 2020
: This paper presents a case study of the landscape of Bulue Village in Soppeng District, Indonesia, showing that site suitability evaluation was an important step in the process of ecotourism development planning of protected area which accommodated the
Eko Yuwono, R. Maulany, R. Barkey
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Changes in land use conflict and zoning optimization in rapidly developing mountainous cities: a case study of Guiyang, China

Journal of Environmental Engineering and Landscape Management
Mountainous cities, influenced by complex human activities and terrain, face severe land use conflict issues. However, the spatiotemporal characteristics of land use conflict changes and the scientific questions regarding their management in rapidly ...
Huiqing Han, Kexin Zhang, Geng Ma
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Suitability evaluation of utilizing urban underground space in the karst area in Gui'an New Area

Carsologica Sinica
In recent years, with the continuous acceleration of urbanization in China, the development and utilization of ground space and aboveground space have gradually become saturated, and various "urban diseases" such as traffic congestion, land resource ...
Hao LI, Qiang YANG, Xuan LUO, Binghu WANG, Changqing SHAO, Siyuan WANG, Qilang LE   +6 more
doaj   +1 more source

Classification and suitability evaluation of soils along a toposequence for rice production in Alabata, Southwest Nigeria

Agro-Science, 2020
Soil classification and suitability evaluation are requirements for attaining optimum utilization of the available land resources. Detailed soil survey of  a top sequence at Alabata, Southwest Nigeria was carried out using the rigid grid method.
O. Osinuga, V. Aiboni, C. O. Oyegoke
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source