Results 131 to 140 of about 23,478 (256)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Association between automated brain volumetry and visual classification of hippocampal atrophy in MRI. [PDF]

Neuroimage Rep
Garrafiel FN, Soder RB, Paganin RP, da Silva MRA, Bieger A, Vidaletti VV, Lazzareti FJ, Zimmer ER, da Costa JC, Aguzzoli CS, Schilling LP.   +10 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Transcriptional and Epigenetic Plasticity Drive an Alternative Non-clonal Mechanism of Resistance to <i>Kras</i> ^G12D Inhibition in Pancreatic Cancer. [PDF]

Cancer Commun (Lond)
Caggiano A, Agostini A, Iacuone D, Priori L, Esposito A, Ceccarelli A, Rosa D, Pasini D, Ugel S, De Sanctis F, Cinti F, Sette C, Vinciguerra GLR, Dezi C, Bronte V, Piro G, Corbo V, Tortora G, Carbone C.   +18 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Daily diet adjustments based on predefined group feeding curves: a practical and scalable approach to enhance nutrient efficiency and sustainability in pig production. [PDF]

Front Vet Sci
Camargo NOT, Furtado JCV, Carvalho CL, Cony BSL, Hauschild L, Dos Santos L, Lunedo R, Perondi D, Andretta I.   +8 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Analysis of neonatal hearing screening coverage by State in Brazil. [PDF]

Braz J Otorhinolaryngol
Jesus GC, Câmara VA, Castilho AM.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Efficacy of Extended Time on Exams for College Students and Applicants With Attention-Deficit/Hyperactivity Disorder: Protocol for a Randomized, Counterbalanced Crossover and Within-Subject Trial. [PDF]

JMIR Res Protoc
Malcon L, Gomes Silva A, Bezerra Falcão A, Bonganhi de Bem É, Grevet F, Wagner F, Duarte I, Barbedo L, Schneider M, Rohde LA, Hoffmann M, Caye A.   +11 more
europepmc   +1 more source