Results 141 to 150 of about 23,478 (256)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Consistent <i>in vitro</i> activity of sulbactam-durlobactam against genetically diverse carbapenem-resistant <i>Acinetobacter baumannii</i> in a high-endemic Brazilian setting. [PDF]

Antimicrob Agents Chemother
Collar GS, Dornelles LS, Salvador JC, Pinto JB, Pereira DC, Barth PO, Cardoso JVB, Matos WL, Mott MP, Barth AL, Martins AF, Caierão J.   +11 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Presentación

Geopauta, 2020
Altemar Amaral Rocha
doaj  

Design, synthesis, antimicrobial and antioxidant evaluation, cytotoxicity assessment, and molecular dynamics-based computational studies of novel PABA analogues as dual DHPS/DHFR inhibitors. [PDF]

RSC Adv
Devliya B, Al-Kubeisi AK, Patel D, Dabhi M, Patel B, Thakar M, Nagapara J, Chauhan S, Rajput K, Goswami D, Dixit N, Patel SK, Sindhav G, Beshay BY, Patel HD.   +14 more
europepmc   +1 more source

Antropologia digital a partir do Sul Global

Cultures-Kairós, 2023
Jair de Souza Ramos, Renan Alfenas de Mattos   +1 more
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Sulbactam-durlobactam and cefiderocol combination treatment of <i>Burkholderia cenocepacia</i>-associated Fitz-Hugh-Curtis syndrome. [PDF]

Antimicrob Agents Chemother
Gaglani B, Andermann TM, Wate C, Oldan J, Desai CS, Marshall SH, Bonomo RA, Coakley R, van Duin D, Lachiewicz A.   +9 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Antimicrobial resistant <i>E. coli</i> in animals, humans and the environment within household and compound settings: A scoping review. [PDF]

One Health
Gutema FD, Kassahun R, Baker KK.
europepmc   +1 more source