Results 211 to 220 of about 24,648 (256)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Proteomic Studies of Pathogenic Fungi and Hosts: A Multidisciplinary Approach to Therapeutics, Diagnostics, and Host Interactions. [PDF]

J Fungi (Basel)
Santi L, Beys-da-Silva WO.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Development of an Electrochemical Reactor Prototype for Biodiesel Production Powered by Photovoltaic Energy. [PDF]

ACS Omega
Rohling GF, Freire JA, Braz KMS, Oliveira Lima F, Lazarin Gallina A, Anjos T, Schumacher RF, Cabreira Soares L.   +7 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

A Multi-Center, Open-Label, Single-Arm, Prospective Investigator Initiated Trial to Evaluate the Efficacy and Safety of Alitretinoin in Patients With Chronic Hand Eczema in Real-World Practice (DWALG_P401) and Overview of Korean Studies. [PDF]

Ann Dermatol
Kwon MJ, Yu JW, Han B, Ahn J, Lee JB, Jeon J, Ko JY, Min JH, Kim JS, Lee UH, Lee SH, Park YL.   +11 more
europepmc   +1 more source

Understanding the Cognitive Load of Cell Phone Use While Walking: Distinct Effects of Texting and Phone Conversation. [PDF]

Brain Sci
Brandão PMF, Ferreira HHB, Oliveira GS, Sobrinho Junior SA, Christofoletti G.   +4 more
europepmc   +1 more source

Factors influencing hepatitis C treatment initiation in a high-prevalence Brazilian state. [PDF]

Cad Saude Publica
Krüger VM, Silva ACAD, Grahl MA, Catasblancas MDA, Lütz ML, Wagner JPS, Silva ALD, Silva EVD, Silva PACD.   +8 more
europepmc   +1 more source

A Scoping Review of Nursing Leadership Role in Global Health: Challenges and Opportunities. [PDF]

Nurs Health Sci
Lemos CS, Spin M, Silveira RRPD, Poveda VB, Magalhães AMM, Lima MADDS, Paixão MLSD, Carvalho SCG, Reynolds N.   +8 more
europepmc   +1 more source