Results 51 to 60 of about 827 (180)

OXA-carbapenemases and mutations within PBPs in ST2 carbapenem-resistant A. baumannii: Evaluating the efficacy of cefiderocol and ampicillin-sulbactam combination therapy [PDF]

Objectives: Carbapenem-resistant Acinetobacter baumannii (A. baumannii; CRAB) isolates represent a serious public health concern. Recently, a novel molecule, the cefiderocol (FDC), has emerged as a promising therapeutic option for CRAB infections. In the
Carannante N., Giuliano S., Mariano B., Martini L., Perilli M., Piccirilli A., Tascini C.   +6 more
core   +1 more source

Microbial Etiology and Antimicrobial Resistance in Pneumonia Among Hospitalized Patients in Kazakhstan: A Systematic Review and Single‐Arm Meta‐Analysis of Prevalence Data

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Pneumonia is an inflammatory condition of the lower respiratory tract, commonly caused by infection and associated with substantial morbidity and healthcare utilization. The burden of pneumonia on healthcare is exacerbated by limited data on pathogenic causes and associated antimicrobial resistance (AMR). Here, we conducted
Radmir Sarsenov, Maxim Solomadin, Alyona Lavrinenko, Vyacheslav Beloussov, Vitaliy Strochkov, Shynggys Orkara, Nurlan Sandybayev, Sergey Yegorov   +7 more
wiley   +1 more source

Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of blaKPC-3 and PBP3 mutations [PDF]

Unlabelled: The emergence of carbapenemase-producing Enterobacterales represents a significant clinical challenge. Resistance mechanisms involve carbapenemase production, porin and efflux pump alterations, penicillin-binding protein (PBP) modifications ...
Angelini, Jacopo, Arcamone, Celeste, Bernaschi, Paola, Bulfoni, Michela, Curcio, Francesco, Di Gennaro, Ciro, Ferin, Sara, Fox, Valeria, Giuliano, Simone, Gualandi, Nicolò, Krpan, Beatrice, Manzi, Rosa, Martini, Luca, Moreal, Chiara, Perno, Carlo Federico, Pipan, Corrado, Stanziola, Maria Cristina, Tascini, Carlo, Turco, Sara   +18 more
core   +1 more source

Datasets comprising the quality validations of simulated protein-ligand complexes and SYBYL docking scores of bioactive natural compounds as inhibitors of protein-targets. [PDF]

, 2022
Docking scores and simulation parameters to study the potency of natural compounds against protein targets in (M) were retrieved through molecular docking and structural investigation.
Anbarasu, Anand, Basu, Soumya, Debroy, Reetika, Miryala, Sravan Kumar, Naha, Aniket, Natarajan, Saravanan, Ramaiah, Sudha   +6 more
core   +1 more source

A Review of β‐Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
β‐Lactam antibiotics have long served as a cornerstone for treating bacterial infections. However, their widespread and often indiscriminate use has fueled the emergence of multidrug‐resistant Gram‐negative pathogens, primarily through the production and dissemination of β‐lactamase enzymes.
Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi, Swaran J. S. Flora   +9 more
wiley   +1 more source

Combination Versus Monotherapy for Carbapenem-Resistant Acinetobacter Species Serious Infections: A Prospective IPTW Adjusted Cohort Study [PDF]

Introduction: International guidelines recommend definitive combination antibiotic therapy for the management of serious infections involving carbapenem-resistant Acinetobacter (CRAB) species.
Abraham, Ooriapadickal Cherian, Bhanuprasad, Kundakarla, Chacko, Binila, Gautam, Priyanka, George, Biju, George, Mithun Mohan, Hansdak, Samuel George, Iyadurai, Ramya, Karthik, Rajiv, Krishnan, Ramya, Kulkarni, Uday, Lal, Binesh, Manesh, Abi, Mathews, Vikram, Mo, Yin, Nagaraj, V., Nivetha, G., Palanikumar, Prasannakumar, Peter, John Victor, Rao, Shoma, Sathyendra, Sowmya, Subramani, K., Triveni, K. Rajitha, Zachariah, Anand   +23 more
core   +2 more sources

Cefiderocol use for the treatment of infections by carbapenem-resistant Gram-negative bacteria: an Italian multicentre real-life experience [PDF]

, 2023
Background: Cefiderocol is a novel siderophore cephalosporin with promising activity against most carbapenem-resistant Gram-negative bacteria (CRGNB). However, extensive postmarketing experiences are lacking.
Bartolini, Andrea, Bartoloni, Alessandro, Bernardo, Mariano, Bianco, Vincenzo, Botta, Annarita, Faragona, Alessandro, Giacometti, Andrea, Giani, Tommaso, Graziani, Lucia, Lagi, Filippo, Morroni, Gianluca, Parrella, Roberto, Piccica, Matteo, Rossolini, Gian Maria, Spinicci, Michele, Tavio, Marcello   +15 more
core   +1 more source

Abstract Supplement

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
 
Marzia Folegani, Semonti Nandi
wiley   +1 more source

Antimicrobial activity of sulbactam-durlobactam against Acinetobacter baumannii-calcoaceticus complex strains causing non-respiratory and non-bloodstream infections from the United States (2023–2025)

Microbiology Spectrum
Acinetobacter baumannii most often causes pneumonia in critically ill patients. However, A. baumannii is also an important cause of a broader range of infections, including skin/wound and urinary tract infections. This study aims to evaluate the in vitro
Elizabeth Cyr, Jill Argotsinger, Eric T. Beck, Robin R. Chamberland, Andrew E. Clark, Anne R. Daniels, Rachael Liesman, Mark Fisher, Philip Gialanella, Jonathan Hand, Amanda T. Harrington, Romney M. Humphries, Holly Huse, Robert Hamilton-Seth, Julia D. Hankins, Wesley D. Kufel, Scott W. Riddell, Meera Mehta, Ryan Demkowicz, A. Brian Mochon, Hossein Salimnia, Ayesha Khan, Virginia M. Pierce, Raghava Potula, Tsigereda Tekle, Patricia J. Simner, Robert J. Tibbetts, Christine Vu, Lilian M. Abbo, Octavio Martinez, Rebekah E. Dumm, Manohar B. Mutnal, Timothy C. Jenkins, Violeta Chávez, Paulette Pinargote, Jennifer Bowling, Erik Munson, Daniel V. Zurawski, David P. Nicolau, Tomefa E. Asempa   +39 more
doaj   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source