Results 61 to 70 of about 827 (180)

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
wiley   +1 more source

Burden and Management of Multi-Drug Resistant Organism Infections in Solid Organ Transplant Recipients Across the World: A Narrative Review [PDF]

Solid organ transplant (SOT) recipients are particularly susceptible to infections caused by multidrug-resistant organisms (MDRO) and are often the first to be affected by an emerging resistant pathogen.
Freire M. P., Giannella M., Manesh A., Pouch S.   +3 more
core   +4 more sources

PNEUMONIA ADQUIRIDA NA COMUNIDADE: UM ESTUDO SOBRE TRATAMENTO EM REGIME DE INTERNAÇÃO [PDF]

A pneumonia adquirida na comunidade (PAC) é uma condição que requer atenção diferenciada, dado seu impacto significativo na saúde pública e nos sistemas de saúde.
Eudyslaine Kennia de Souza, Maria Caroline Moyses Bastos, Roberto Spadoni Campigotto, Yamila Audrey Santos Costa   +3 more
core   +2 more sources

Pharmacokinetics of continuous infusion ceftolozane/tazobactam in two patients with extensive total body surface area burns

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 6, Page 386-392, June 2025.
Abstract Introduction Treatment of infections in patients with burn injuries is challenging due to altered antimicrobial pharmacokinetics. Continuous infusion β‐lactam therapy may be a useful antimicrobial stewardship strategy to improve pharmacodynamic target attainment in this population.
Jay D. Olivet, Megan Amerson‐Brown, Juan J. Calix, Emma Graffice, Tyson Kilpatrick, Hanna F. Roenfanz, David P. Nicolau, Joseph L. Kuti, Matthew L. Brown   +8 more
wiley   +1 more source

Microbiological eradication of XDR Acinetobacter baumannii intra-abdominal infection using sulbactam-durobactam: clinical and microbiological outcomes amidst irreversible host comorbidities

Frontiers in Medicine
BackgroundThe management of extensively drug-resistant (XDR) Acinetobacter baumannii (CRAB) in deep-seated infections remains a critical challenge, particularly when compounded by severe host comorbidities.Case presentationWe report the case of a 63-year-
Lei Yu, Jieli He, Waiming Chan, Waiming Chan, Shan Zou, Qingshan Zhou, Jun Jin   +6 more
doaj   +1 more source

Neumonía asociada a la ventilación mecánica. [PDF]

Introduction: Ventilator-associated pneumonia is a healthcare-associated infection that causes increased morbidity and mortality in the intensive care unit 48 hours after endotracheal intubation and invasive mechanical ventilation.
Canales Vélez , Stefanny Michell, Chalco Román , Graciela Jemima, Cárdenas Matute, Rebeca Tamara, Hidalgo Acosta, Javier Aquiles, Toala Zambrano, Gabriela Roxana   +4 more
core   +2 more sources

A review of antibiotic safety in pregnancy—2025 update

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 4, Page 227-237, April 2025.
Abstract Antibiotics constitute the majority of prescriptions for women during pregnancy. Common bacterial infections, including urinary tract infections, skin and soft tissue infections, and upper and lower respiratory tract infections, are expected in pregnancy, similar to the general public.
Johny Nguyen, Victoria Madonia, Christopher M. Bland, Kayla R. Stover, Lea S. Eiland, Julia Keating, Madeline Lemmon, P. Brandon Bookstaver, as part of the Southeastern Research Group Endeavor (SERGE‐45) research network   +8 more
wiley   +1 more source

Multidrug-Resistant Acinetobacter baumannii: Resistance Mechanisms, Emerging Therapies, and Prevention—A Narrative Review

Antibiotics
Acinetobacter baumannii is a leading intensive care unit (ICU) pathogen associated with high rates of carbapenem resistance and poor clinical outcomes.
Ioana Adelina Stoian, Bianca Balas Maftei, Carmen-Elena Florea, Alexandra Rotaru, Constantin Aleodor Costin, Maria Antoanela Pasare, Radu Crisan Dabija, Carmen Manciuc   +7 more
doaj   +1 more source

Synthesis and Evaluation of Carbapenem/Metallo‐β‐Lactamase Inhibitor Conjugates

ChemMedChem, Volume 19, Issue 21, November 4, 2024.
We report the synthesis and evaluation of molecular conjugates that combine a carbapenem antibiotic (meropenem or ertapenem) with a recently reported indole carboxylate scaffold. These hybrids are potent inhibitors of metallo‐β‐lactamases including the clinically relevant NDM‐1 and IMP‐1 enzymes.
Mei‐Ling Gao, Ioli Kotsogianni, Foteini Skoulikopoulou, Nora C. Brüchle, Paolo Innocenti, Nathaniel I. Martin   +5 more
wiley   +1 more source

Acinetobacter baumannii Complex Infections: New Treatment Options in the Antibiotic Pipeline

Microorganisms
Acinetobacter baumannii complex (ABC) can result in a panoply of severe syndromes, including pneumonia and septic shock. Options available for treating infections caused by ABC and, more importantly, by carbapenem-resistant ABC (CRAB) are limited because
Noayna Arshad, Wael Azzam, Marya D. Zilberberg, Andrew F. Shorr   +3 more
doaj   +1 more source