Results 101 to 110 of about 20,006 (291)

Nanoformulation and Preclinical Evaluation of Dihydroartemisinin–Lumefantrine and Primaquine as Combined Antimalarial Therapy

Journal of Nanotechnology, Volume 2025, Issue 1, 2025.
The World Health Organization recommends artemisinin‐based combinations for uncomplicated malaria treatment. Artemether and lumefantrine (LUM) are the first‐line treatments, with artemether serving as a prodrug of dihydroartemisinin (DHA), while primaquine (PQ) is primarily used as a prophylactic drug.
Pesila Odera, Geoffrey Otieno, Joab Onyango, Bernhards Ogutu, James Owour, Florence Oloo, Martin Ongas, Hulda Swai, Jeremiah Gathirwa, Arnab Biswas   +9 more
wiley   +1 more source

Five years of antimalarial resistance marker surveillance in Gaza Province, Mozambique, following artemisinin-based combination therapy roll out. [PDF]

PLoS ONE, 2011
Antimalarial drug resistance is a major obstacle to malaria control and eventual elimination. The routine surveillance for molecular marker of resistance is an efficient way to assess drug efficacy, which remains feasible in areas where malaria control ...
Jaishree Raman, Katya Mauff, Pedro Muianga, Abdul Mussa, Rajendra Maharaj, Karen I Barnes   +5 more
doaj   +1 more source

Prevalence of molecular markers of sulfadoxine–pyrimethamine and artemisinin resistance in Plasmodium falciparum from Pakistan

Malaria Journal, 2018
In Pakistan, artesunate (AS) in combination with sulfadoxine–pyrimethamine (SP) is the recommended treatment for uncomplicated Plasmodium falciparum malaria. Monitoring molecular markers of anti-malarial drug resistance is crucial for early detection and
A. Yaqoob, A. Khattak, M. Nadeem, Huma Fatima, Gillian Mbambo, A. Ouattara, Matthew Adams, N. Zeeshan, Shannon Takala-Harrison   +8 more
semanticscholar   +1 more source

Parasitaemia and gametocytaemia after treatment with chloroquine, pyrimethamine/sulfadoxine, and pyrimethamine/sulfadoxine combined with artesunate in young Gambians with uncomplicated malaria [PDF]

Tropical Medicine & International Health, 2001
As part of a study to assess the infectivity of gametocytes after treatment with four antimalarial regimens, the efficacy of each treatment was also determined. From September to December 1998, 598 children with uncomplicated malaria were treated; 135 received chloroquine (CQ) alone, 276 received pyrimethamine/sulfadoxine (Fansidar©, PSD) alone, 113 ...
Gijs Walraven, Rosalind Coleman, Geoffrey A. T. Targett, Geoffrey A. T. Targett, Tom Doherty, Tom Doherty, Musa Jawara, Lorenz von Seidlein, Lorenz von Seidlein   +8 more
openaire   +3 more sources

Evaluating the Antiplasmodial Activity of Picrasma javanica Stem Bark Extract and Its Synergy With Artesunate in Rodent Malaria Models

Scientifica, Volume 2025, Issue 1, 2025.
Malaria remains a global health challenge, exacerbated by the emergence of drug‐resistant Plasmodium strains. This study evaluates the antimalarial activity of Picrasma javanica stem bark extract and its combination with artesunate (ART) in Plasmodium berghei–infected mice. The extraction yield using hexane at a 1:5 (w/v) ratio was 7.8% w/w.
Sakaewan Ounjaijean, Voravuth Somsak, Simone Carradori   +2 more
wiley   +1 more source

A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women. [PDF]

PLoS ONE, 2007
New anti-malarial regimens are urgently needed in sub-Saharan Africa because of the increase in drug resistance. We investigated the safety and efficacy of azithromycin or artesunate combined with sulfadoxine-pyrimethamine used for treatment of malaria ...
Linda Kalilani, Innocent Mofolo, Marjorie Chaponda, Stephen J Rogerson, Alisa P Alker, Jesse J Kwiek, Steven R Meshnick   +6 more
doaj   +1 more source

Intermittent preventive treatment of malaria in pregnancy: a cross-sectional survey to assess uptake of the new sulfadoxine–pyrimethamine five dose policy in Ghana

Malaria Journal, 2017
Malaria in pregnancy poses a great risk to both mother and fetus. In Ghana, malaria accounts for 3.4% of deaths and 16.8% of all hospital admissions in pregnant women.
I. Owusu-Boateng, F. Anto
semanticscholar   +1 more source

Gametocytes: insights gained during a decade of molecular monitoring [PDF]

, 2008
In vertebrate hosts, malaria parasites produce specialized male and female sexual stages (gametocytes). Soon after being taken up by a mosquito, gametocytes rapidly produce gametes and, once mated, they infect their vector and can be transmitted to new ...
Abdel-Wahab, Akim, Alano, Ali, Babiker, Babiker, Babiker, Babiker, Bell, Billingsley, Bonnet, Boudin, Bousema, Bousema, Bousema, Buckling, Buckling, Buckling, de Roode, Dixon, Drakeley, Drew, Dunyo, Dye, El-Sayed, Farnert, Farnert, Ferguson, Gaillard, Gardner, Gautret, Graves, Hamza A. Babiker, Hill, Huber, Jarvi, Jeffery, Kooij, Menegon, Mideo, Nassir, Nee, Niederwieser, Nwakanma, Okell, Osorio, Ouédraogo, Paganotti, Paul, Paul, Paul, Paul, Petra Schneider, Pichon, Pradel, Read, Reece, Reece, Robert, Sarah E. Reece, Schall, Schall, Schneider, Schneider, Schneider, Shekalaghe, Shekalaghe, Shutler, Shutler, Smith, Sokhna, Sowunmi, Talman, Talman, Targett, Trager, Vardo, Wargo, Wargo, Wargo, Werren, West   +81 more
core   +2 more sources

Sulfadoxine Resistance in Plasmodium vivax Is Associated with a Specific Amino Acid in Dihydropteroate Synthase at the Putative Sulfadoxine-Binding Site [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACT Sulfadoxine is predominantly used in combination with pyrimethamine, commonly known as Fansidar, for the treatment of Plasmodium falciparum . This combination is usually less effective against Plasmodium vivax , probably due to the innate refractoriness of parasites to the ...
Korsinczky, M., Fischer, K., Chen, N. H., Baker, J., Rieckmann, K., Cheng, Q.   +5 more
openaire   +4 more sources

Sulfadoxine-Pyrimethamine Exhibits Dose-Response Protection Against Adverse Birth Outcomes Related to Malaria and Sexually Transmitted and Reproductive Tract Infections

Clinical Infectious Diseases, 2017
Summary Compared to 0–1 dose of intermittent preventive treatment of malaria using sulfadoxine-pyrimethamine, ≥2 doses protects pregnant women against adverse birth outcomes attributable to malaria infection and to curable sexually transmitted and ...
R. Chico, E. B. Chaponda, E. B. Chaponda, C. Ariti, D. Chandramohan   +4 more
semanticscholar   +1 more source