Results 121 to 130 of about 372,261 (217)

Sulfide Quinone Oxidoreductase Alleviates Acute Ulcerative Colitis by Regulating Mitochondrial Dysfunction

MedComm, Volume 6, Issue 7, July 2025.
SQOR deficiency in intestinal epithelial cells aggravated DSS‐induced acute colitis and disrupted the integrity of intestinal tight junctions. Moreover, SQOR plays a vital role in regulating the mitochondrial function of intestinal epithelial cells.
Hailin Ma, Shuilian Fu, Chujun Huang, Na Han, Fangfang Cai, Dangran Li, Jian Cheng, Hongqin Zhuang, Zi‐Chun Hua   +8 more
wiley   +1 more source

Is Endothelial Nitric Oxide Synthase a Moonlighting Protein Whose Day Job is Cholesterol Sulfate Synthesis? Implications for Cholesterol Transport, Diabetes and Cardiovascular Disease [PDF]

, 2012
Theoretical inferences, based on biophysical, biochemical, and biosemiotic considerations, are related here to the pathogenesis of cardiovascular disease, diabetes, and other degenerative conditions.
Ali, Ann Lauritzen, Billecke, Brune, Cignarelli, Cordelier, Deniziak, Dimmeler, Drayer, Gajkowska, Girard, Gross, Hao, Hart, Ho, Hopwood, Hopwood, Ignarro, Jagger, Jakubowski, Joensuu, Laurie Lentz-Marino, McCully, Nakae, Pfennig, Pollack, Randriamboavonjy, Rearick, Robert Davidson, Seidel, Stephanie Seneff, Suzuki, Tedder, Teske, Tsai, Voeikov   +35 more
core   +4 more sources

Evaluation of Anticancer and Anti‐Inflammatory Activities of Some Benzothiophene‐Based Artemisinin

ChemistrySelect, Volume 10, Issue 28, July 25, 2025.
Two different benzothiophene–artemisinin hybrids (BTPART and BTFART) exhibited dose‐dependent cytotoxicity, reduced colony formation, and demonstrated anti‐metastatic effects in various cancer cell lines including Caco‐2, HepG2, LNCaP, and MDA‐MB‐231. Flow cytometry and qPCR analyses revealed that they induced apoptosis by modulating the expression of ...
Kübra Kocabıyık, Omrüye Özok‐Arici, Arif Kivrak, Sevki Arslan   +3 more
wiley   +1 more source

Heme ligation and redox chemistry in two bacterial thiosulfate dehydrogenase (TsdA) enzyme [PDF]

, 2019
Thiosulfate dehydrogenases (TsdA) are bidirectional bacterial di-heme enzymes that catalyze the interconversion of tetrathionate and thiosulfate at measurable rates in both directions.
Bradley, Justin M., Butt, Julea N., Cheesman, Myles, Dahl, Christiane, Jenner, Leon P., Kurth, Julia M., Reisner, Erwin, Sokol, Katarzyna P., van Helmont, Sebastian   +8 more
core   +1 more source

An Iron‐Catalyzed Sustainable Functional Group Transfer Strategy for In‐Water Transformation of Organic Sulfides to Sulfoxides by a Hydroxylamine‐Derived Oxidant

ChemSusChem, Volume 18, Issue 12, June 17, 2025.
An iron‐catalyzed ecofriendly reaction protocol is demonstrated to chemoselectively convert readily available organic sulfides to valuable sulfoxides, under mild reaction conditions in water. The functional group tolerance, scalability, reaction compatibility, and potential application make the protocol highly attractive in terms of green and ...
Arya Singh, Yashdeep Maurya, Akhilesh Sharma, Swetha Vasanthdamodar Sivapreetha, Mehar Ul Nisa, Vishal Kumar, Puneet Gupta, Kartikay Tyagi, Sayanti Chatterjee   +8 more
wiley   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, Volume 12, Issue 20, May 29, 2025.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals

Molecules, 2016
It was in the 1950s that the term polysulfide or persulfide was introduced in biological studies. The unfamiliar term “sulfane sulfur” sometimes appeared in papers published in the 1970s, and was defined in the review article by Westley in 1983.
Shin Koike, Yuki Ogasawara
doaj   +1 more source

Transcriptomics of the Anthopleura Sea Anemone Reveals Unique Adaptive Strategies to Shallow‐Water Hydrothermal Vent

Ecology and Evolution, Volume 15, Issue 4, April 2025.
The nonsymbiotic sea anemone Anthopleura nigrescens thrives in the extreme shallow‐water hydrothermal vents off Kueishan Island, Taiwan, where they represent some of the world's most extreme environments. Transcriptomic analyses revealed that genes involved in H2S homeostasis, stress resistance, and DNA repair are enriched in vent populations ...
Mei‐Fang Lin, Li‐Lian Liu, Chen‐Tung Arthur Chen   +2 more
wiley   +1 more source

Transfer of Sulfur from IscS to IscU during Fe/S Cluster Assembly [PDF]

, 2001
The cysteine desulfurase enzymes NifS and IscS provide sulfur for the biosynthesis of Fe/S proteins. NifU and IscU have been proposed to serve as template or scaffold proteins in the initial Fe/S cluster assembly events, but the mechanism of sulfur ...
Hoff, Kevin G., Silberg, Jonathan J., Urbina, Hugo D., Vickery, Larry E.   +3 more
core   +1 more source

Altered Mitochondrial Bioenergetics and Calcium Kinetics in Young‐Onset PLA2G6 Parkinson's Disease iPSCs

Journal of Neurochemistry, Volume 169, Issue 4, April 2025.
Contrary to the neuro‐centric view of Parkinson's disease (PD) pathology, it has been proposed that early phenotypes of PD manifest in peripheral tissues, suggesting that patient‐derived stem cells may exhibit disease‐related changes prior to neuronal differentiation. In this study, we examined cellular hallmarks of human induced pluripotent stem cells
Thasneem Musthafa, Syed Kavish Nizami, Ankita Mishra, Gaiti Hasan, Renjitha Gopurappilly   +4 more
wiley   +1 more source