Results 91 to 100 of about 26,729 (245)

Agranulocytosis Associated with Sulfasalazine

, 1988
Agranulocytosis is a rare but potentially lethal adverse effect of sulfasalazine. We report a case of sulfasalazine-associated agranulocytosis that occurred in a 79-year-old woman who had been taking the drug for approximately seven weeks.
Christine L. Derry, Terry L. Schwinghammer   +1 more
core   +1 more source

The effects of conventional drugs in the treatment of rheumatoid arthritis on the serum lipids

Journal of Research in Medical Sciences, 2018
Background: Rheumatoid arthritis (RA) is a common chronic autoimmune disorder that leads to damage of human joints. There are various treatment approaches in which different drugs are prescribed which have several alterations in serum lipids.
Mansoor Karimifar, Mohammad S Sepehrifar, Hamidreza Moussavi, Mohammad B Sepehrifar, Peyman Mottaghi, Mansour Siavash, Mozhgan Karimifar   +6 more
doaj   +1 more source

Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers. [PDF]

, 2005
Background: Bile acid-induced apoptosis in hepatocytes can be antagonized by NF-κBdependent survival pathways. Sulfasalazine modulates NF-κB in different cell types. We aimed to determine the effects of sulfasalazine and its metabolites sulfapyridine and
Berndt, C., Beuers, Ulrich, Bauchmüller, Kris Benjamin, Vennegerts, Timo, Fuchsbichler, A., Bernt, C., Vennegeerts, T., Rust, C., Beuers, U., Rust, Christian, Fickert, P., Bauchmuller, K., C Rust   +12 more
core   +2 more sources

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Baicalin Induces Ferroptosis in Breast Cancer Through a Novel STAT3/HO‐1/GPX4 Regulatory Axis

Phytotherapy Research, EarlyView.
BA inhibits STAT3 phosphorylation and activation in BC cells, accompanied by decreased expression of HO‐1 and GPX4. Reduced GPX4 activity impairs lipid peroxide clearance, promoting ROS accumulation and lipid peroxidation, which ultimately triggers ferroptosis and inhibits cell proliferation.
Tingting Guo, Fansu Meng, Detang Li, Maciej Mazur, Alicia Marcelina Díaz García, Mulazim Hussain Asim, Zhong Chen, Yiqi Chen, Yixuan Lin, Zhenjiang Yang, Panpan Wang, Yu Cai   +11 more
wiley   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Potential of Ginkgo biloba Extract to Intervene in Chronic Inflammation‐Related Diseases

Phytotherapy Research, EarlyView.
Chronic inflammation is a pathological mechanism underpinning many diseases. Ginkgo biloba extract (GBE) is well known for its anti‐inflammatory property. GBE and its active constituents have been shown to attenuate pro‐inflammatory cytokine production, suppress nuclear factor kappa B activation, restore redox homeostasis, and modulate disease‐relevant
Yipeng Lin, Inho Cho, Xue Zhu, Ke Wang, Ling Zhu, Wenchang Wong, Michael Murray, Fanfan Zhou   +7 more
wiley   +1 more source

Effects of sulfasalazine in axial spondyloarthritis on COVID-19 outcomes: real-life data from a single center

, 2022
© 2022 Informa UK Limited, trading as Taylor & Francis Group.Introduction: Compared to biological agents, little is known about the impact of sulfasalazine therapy on COVID-19 outcomes in patients with Axial Spondyloarthritis (AxSpA). Therefore, we aimed
Bahar Özdemir, Gök, Kevser, Maraş, Yüksel, Akyüz Dağlı, Pınar, Şükran Erten, Abdulsamet Erden, Berkan Armağan, Omma, Ahmet, Küçükşahin, Orhan, Armağan, Berkan, Hatice Ecem Konak, Yüksel Maraş, Ahmet Omma, Güven, Serdar Can, Konak, Hatice Ecem, Erden, ABDULSAMET, Atalar, Ebru, Özdemir, Bahar, Ebru Atalar, Kevser Gök, Serdar Can Güven, İsmail Doğan, Erten, Şükran, Pınar Akyüz Dağlı, DOĞAN, İSMAİL, Orhan Küçükşahin   +25 more
core   +1 more source

Drug reaction with eosinophilia and systemic symptoms (dress) syndrome associated with sulfasalazine without eosinophilia

Sri Lanka Journal of Medicine, 2019
A 28-year-old previously healthy woman presented with fever and constitutional symptoms for one week duration. Prior to the hospital admission, she had been treated for an inflammatory arthritis with sulfasalazine for three months duration.
K. S. Hettiarachchi, M. M. Ranasinghe, S. Pirasath, A. G. H. Sugathapala   +3 more
doaj   +1 more source

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source