Results 111 to 120 of about 3,260 (184)

Sulfasalazine-Induced Urinary Normetanephrine Elevation Mimicking Recurrent Phaeochromocytoma—A Case Report

Case Reports in Endocrinology
Phaeochromocytomas and paragangliomas (PPGLs) are catecholamine-secreting neuroendocrine tumours (NETs) of the adrenal medulla and autonomic nervous system. Early recognition and management is critical given their potential morbidity and mortality.
Maria Hadjicosti, Anastasia Papapostolou, Michail Papoulas, Evdoxia Poulianiti, Nikoleta Christodoulidou, Michalis K. Picolos   +5 more
doaj   +1 more source

The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites.

, 1996
The anti-inflammatory mechanism of sulfasalazine is not well understood. It has recently been shown that sulfasalazine inhibits 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR) transformylase, an enzyme involved in de novo purine biosynthesis.
Naime, D, Recht, P A, Montesinos, M C, Carlin, G, Longaker, M, Levin, R I, Cronstein, B N, Buckley, M T, Gadangi, P   +8 more
core  

Sulfasalazine prevents T-helper 1 immune response by suppressing interleukin-12 production in macrophages.

, 1999
Interleukin-12 (IL-12) plays a pivotal role in the development of T- helper 1 (Th1) immune response, which may be involved in the pathogenesis of chronic inflammatory autoimmune disorders.
T S Kim, S W Chung, Yong Kyung Choe, S Y Im, B Y Kang   +4 more
core   +1 more source

Clinical features and comorbidity patterns in early and very early rheumatoid arthritis: Insights from a China nationwide survey

Rheumatology &Autoimmunity, EarlyView.
Haojie Xu, Liyun Zhang, Yuehong Huo, Rui Wu, Lijun Wu, Ling Lei, Linyu Geng, Chunyu Tan, Xiaomei Li, Ru Li, Yin Su, the Women's Rheumatoid Arthritis Research Collaborative Group   +11 more
wiley   +1 more source

Liver Injury From Medications Used for Treating Inflammatory Bowel Disease: The Drug‐Induced Liver Injury Network Experience

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Background We aimed to investigate and characterise DILI due to approved therapies for inflammatory bowel disease (IBD). Methods Using the Drug‐Induced Liver Injury Network (DILIN) prospective study, we evaluated definite, highly likely, or probable DILI attributed to IBD therapies, including use for non‐IBD indications (but excluding ...
Harish Gopalakrishna, Jiezhun Gu, Yi‐Ju Li, Huiman Barnhart, Dina Halegoua‐DeMarzio, Herbert L. Bonkovsky, A. Sidney Barritt, Jean P. Molleston, Naga P. Chalasani, Marwan Ghabril   +9 more
wiley   +1 more source

Sulfasalazine-Induced DRESS Syndrome: A Case Report

JK Science
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but potentially fatal drug hypersensitivity reaction. We report a 13-year-old male with enthesitis-related arthritis who developed DRESS three weeks after initiating ...
Nikhil R, Himabindu Jayaprakash Narayan, Ramaswamy Subramanian, Shiva Prasad BN, Mahabaleshwar Mamadapur, Bharath Raj Srinivasan   +5 more
doaj  

Sulfasalazine-induced renal injury in rats and the protective role of thiol-reductants

, 2015
Sulfasalazine is widely used for inflammatory-mediated disorders in human. Renal damage is a serious adverse effect accompanied sulfasalazine administration. No specific therapeutic option is available against this complication so far.
Heidari, R, Rahimi, HR, Shirazi Yeganeh, B, Najibi, A, Taheri, V, Niknahad, H   +5 more
core  

Long‐Term Outcomes of Reduced‐Intensity Conditioning Hematopoietic Stem Cell Transplantation for Patients With Systemic Sclerosis With Impaired Cardiac Function

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1294-1305, June 2026.
Objective High‐intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced systemic sclerosis (SSc). The role of reduced‐intensity conditioning (RIC) before AHSCT in this population remains unclear.
Yonatan Lean, Carrie Richardson, Anthony J. Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

Translational Modeling of Gut Microbiome‐Mediated Drug Metabolism: A Case Example of Sulfasalazine

CPT: Pharmacometrics & Systems Pharmacology
The gut microbiome can contribute to drug metabolism and significantly influence pharmacokinetic (PK) behavior. Sulfasalazine is well‐known to be metabolized by gut bacterial azoreductases into sulfapyridine and mesalamine.
Lisa Cheng, Jingwei Cai, Alexis Auster, Sungjoon Cho, Mary Keir, Horace Rhee, Bennett Kapili, Dari Shalon, Miaoran Ning   +8 more
doaj   +1 more source

Sulfasalazine intensifies temozolomide cytotoxicity in human glioblastoma cells

, 2017
Temozolomide (TMZ) is an alkylating agent used to treat glioblastoma. This tumor type synthesizes the antioxidant glutathione through system X (c) (-) , which is inhibited by sulfasalazine (SAS).
Vieira , André Schwambach, Lopes-Cendes, Iscia, Castilho, Roger Frigério, Rogerio, Fabio, Melo, Daniela Rodrigues de, Facchini, Gustavo, Ignarro, Raffaela Silvestre   +6 more
core   +1 more source