Results 121 to 130 of about 3,260 (184)

OGFRL1 Deficiency Causes Chronic Recurrent Multifocal Osteomyelitis Via Pathologic Osteoclastogenesis, With Therapeutic Response to Tumor Necrosis Factor Inhibitor

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1318-1326, June 2026.
Objective To verify the pathogenesis of the opioid growth factor receptor like‐1 (OGFRL1) loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a patient with chronic recurrent multifocal osteomyelitis (CRMO) and to investigate the underlying mechanism.
Wen Xiong, Yusha Wang, Tingyan He, Jinjian Fu, Ying Luo, Jinbo Wang, Jun Wang, Xiaomin Yu, Qing Zhou, Jun Yang   +9 more
wiley   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Severe Cutaneous Adverse Reactions Associated With Newer‐Generation Antiseizure Medications: A Real‐World Pharmacovigilance Study Based on FAERS and JADER

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
A cross‐database analysis of FAERS and JADER confirmed lamotrigine and zonisamide as the dominant SJS/TEN/DRESS risk drivers across both systems. After polytherapy adjustment, eslicarbazepine (DRESS, ROR 10.41) and levetiracetam emerged as reproducible novel signals warranting clinical attention. SJS/TEN onset concentrated within 4 weeks, whereas DRESS
Longfei You, Dong Zhang, Zhihua Cheng, Yinbao Qi, Ruobing Qian   +4 more
wiley   +1 more source

Diagnostic Accuracy of Salivary Periodontal Biomarkers Is Reduced in Patients With Crohn's Disease

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Patients with Crohn's disease (CD) are at increased risk of developing periodontal disease and may benefit from salivary biomarker–based monitoring for early detection and management. Given the previously reported reduced specificity of the salivary aMMP‐8 test in CD, this study aimed to evaluate alternative salivary biomarkers for ...
Alisa Toivanen, Nur, Ismo Räisänen, Mervi Gürsoy, Ulvi Kahraman Gürsoy, Timo Sorsa, Jaana Rautava   +6 more
wiley   +1 more source

Exploring the Crystal Structure Landscape of Sulfasalazine through Various Multicomponent Crystals

Sulfasalazine is used as an anti-inflammatory drug to treat large intestine diseases and atrophic arthritis. In the solid state, two tautomers are known: an amide tautomer (triclinic polymorph) and an imide tautomer (monoclinic polymorph ...
Vinay K. R. Cheemarla (14701385), Davide Tiana (784713), Simon E. Lawrence (1444243), Shan Huang (282228)   +3 more
core   +1 more source

Sulfasalazine treatment can cause a positive effect on LPS-induced endotoxic rats

, 2018
The aim of this study, was to determine the effect of sulfasalazine for different periods of time reduces disseminated intravascular coagulation, inflammation and organ damages by inhibiting the nuclear factor kappa beta pathway.
Emre Bahcivan, Burak Dik, Gonca Sonmez, Hatice Eser Faki, Dik, Burak, Fakı, Hatice Eser, Bahcıvan, Emre, Sönmez, Gonca   +7 more
core   +1 more source

Unraveling Inflammatory Pain: A Narrative Review of Molecular Pathways and Multidisciplinary Treatments

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Inflammatory pain is a widespread global health concern arising from complex molecular pathways triggered by a consequence of tissue damage and immune activation. It significantly impacts quality of life and functional outcomes, necessitating a comprehensive understanding of underlying mechanisms and multidisciplinary approaches for
Fatma Mohamed Elmansy, Mohamed Goda Elbqry, Saddam Ahmed Al‐Ahdal, Fatima S. O. Ashmieg, Patience Osose Nasir, Nasiru Mohammed Abdullahi, Mohammed Nader Shalaby   +6 more
wiley   +1 more source

DRESS syndrome without eosinophilia presented with extensive skin rash and acute respiratory failure

Clinical Case Reports
Key Clinical Message This case demonstrated the complex pathophysiology of DRESS syndrome presenting with latent human herpes virus infection reactivation due to exposure to sulfasalazine and/or hydroxychloroquine.
Nattanicha Chaisrimaneepan, Corley Pruneda, Marwan Elmassry, Mahmoud Abdelnabi   +3 more
doaj   +1 more source

Clinical Features and Therapeutic Outcomes in Pyoderma Gangrenosum: A Prospective Cohort Study

JEADV Clinical Practice, Volume 5, Issue 2, Page 495-501, June 2026.
ABSTRACT Background Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis highly associated with systemic comorbidities. Accurate diagnosis and treatment remain challenging due to its rarity and clinical mimickers. Objectives To evaluate demographic, clinical features and treatment outcomes in patients referred with suspected PG at a tertiary ...
David Croitoru, Nesrine Brahimi, Haleh Zabihi, Cathryn Sibbald, Kyle Seigel, Delaram Shojaei, Eric McMullen, Afsaneh Alavi, Lily Archaempong, Aaron M. Drucker, Adam Weizman, Kenneth Croitoru, Robert Inman, Vincent Piguet   +13 more
wiley   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source