Results 131 to 140 of about 28,914 (292)

Functional and Genetic Characterization of Sulfatases in Salmonella Enterica Serovar Typhimurium [PDF]

, 2014
Salmonella enterica serovar Typhimurium is a gram-negative facultative intracellular food borne pathogen and accounts for $365 million in direct medical costs annually. The ability of S.
Das, Seema
core   +1 more source

Dehydroepiandrosterone sulfate mediates activation of transcription factors CREB and ATF-1 via a Gα11-coupled receptor in the spermatogenic cell line GC-2 [PDF]

, 2013
Dehydroepiandrosterone sulfate (DHEAS) is a circulating steroid produced in the adrenal cortex, brain, and gonads. Whereas a series of investigations attest to neuroprotective effects of the steroid in the brain, surprisingly little is known about the ...
Adam, Jaroslav, Adamová, Dagmar, Aggarwal, Madan M., Aglieri Rinella, Gianluca, Agnello, Michelangelo, Agrawal, Nikita, Ahammed, Zubayer, Ahmad, Shafiq F., Ahn, Sang Un, Aiola, Salvatore, Akindinov, Alexander, Alam, Sk Noor, Aleksandrov, Dimitry, Alessandro, Bruno, Alexandre, Didier, Alfaro Molina, José Rubén, ALICE, Collaboration, Alme, Johan, Altinpinar, Sedat, Arsene, Ionut Christian, Bätzing, Paul Christoph, De Albuquerque, Danilo Silva, Djuvsland, Øystein, Dordic, Olja, Eyyubova, Gyulnara, Helstrup, Håvard, Hetland, Kristin Fanebust, Kileng, Bjarte, Langøy, Rune, Lien, Jørgen André, Lindal, Svein, Lønne, Per-Ivar, Mahmood, Sohail Musa, Milosevic, Jovan, Nystrand, Joakim, Qvigstad, Henrik, Rehman, Attiq ur, Richter, Matthias, Røed, Ketil, Røhrich, Dieter, Skaali, Toralf Bernhard, Tambave, Ganesh Jagannath, Tveter, Trine Spedstad, Ullaland, Kjetil, Velure, Arild, Wagner, Boris, Wikne, Jon Christopher, Zhang, Hui, Zhao, Chengxin, Zhou, Zhuo, Zhu, Hongsheng   +50 more
core   +1 more source

Detection of Sulfatase Enzyme Activity with a CatalyCEST MRI Contrast Agent.

Chemistry, 2016
A chemical exchange saturation transfer (CEST) MRI contrast agent has been developed that detects sulfatase enzyme activity. The agent produces a CEST signal at δ=5.0 ppm before enzyme activity, and a second CEST signal appears at δ=9.0 ppm after the ...
S. Sinharay, Gabriela Fernández-Cuervo, Jasmine P Acfalle, M. Pagel   +3 more
semanticscholar   +1 more source

Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase.

ACS Chemical Biology, 2017
The degradation of glycosaminoglycans (GAGs) involves a series of exolytic glycosidases and sulfatases that act sequentially on the nonreducing end of the polysaccharide chain.
Omkar P. Dhamale, R. Lawrence, E. M. Wiegmann, B. A. Shah, Kanar al-Mafraji, William C. Lamanna, T. Lübke, T. Dierks, G. Boons, J. Esko   +9 more
semanticscholar   +1 more source

Quantification of the enzyme activities of iduronate-2-sulfatase, N-acetylgalactosamine-6-sulfatase and N-acetylgalactosamine-4-sulfatase using liquid chromatography-tandem mass spectrometry

Molecular Genetics and Metabolism Reports, 2018
Mucopolysaccharidosis (MPS) is a genetic disorder characterized by the accumulation of glycosaminoglycans in the body. Of the multiple MPS disease subtypes, several are caused by defects in sulfatases.
Ryuichi Mashima, Mari Ohira, Torayuki Okuyama, Akiya Tatsumi   +3 more
doaj   +1 more source

Natural disease history and characterisation of SUMF1 molecular defects in ten unrelated patients with multiple sulfatase deficiency

Orphanet Journal of Rare Diseases, 2015
BackgroundMultiple sulfatase deficiency is a rare inherited metabolic disorder caused by mutations in the SUMF1 gene. The disease remains poorly known, often leading to a late diagnosis.
F. Sabourdy, L. Mourey, E. Le Trionnaire, N. Bednarek, C. Caillaud, Y. Chaix, M. Delrue, A. Dusser, R. Froissart, R. Garnotel, N. Guffon, A. Mégarbané, H. Ogier de Baulny, J. Pedespan, S. Pichard, V. Valayannopoulos, A. Verloes, T. Levade   +17 more
semanticscholar   +1 more source

High levels of oxysterol sulfates in serum of patients with steroid sulfatase deficiency[S]

Journal of Lipid Research, 2015
Steroid sulfatase (STS) deficiency is the underlying cause of the skin condition known as recessive X-linked ichthyosis (RXLI). RXLI patients show scales on their skin caused by high concentrations of cholesterol sulfate (CS), as they are not capable of ...
A. Sánchez-Guijo, V. Oji, M. Hartmann, H. Schuppe, H. Traupe, S. Wudy   +5 more
semanticscholar   +1 more source

Synthesis and structure–activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Ring A halogenated 13α-, 13β-, and 17-deoxy-13α-estrone derivatives were synthesised with N-halosuccinimides as electrophile triggers. Substitutions occurred at positions C-2 and/or C-4.
Ildikó Bacsa, Bianka Edina Herman, Rebeka Jójárt, Kevin Stefán Herman, János Wölfling, Gyula Schneider, Mónika Varga, Csaba Tömböly, Tea Lanišnik Rižner, Mihály Szécsi, Erzsébet Mernyák   +10 more
doaj   +1 more source

Steroid sulfatase activity in subcutaneous and visceral adipose tissue: a comparison between pre- and postmenopausal women.

European Journal of Endocrinology, 2015
OBJECTIVE Adipose tissue is an important extragonadal site for steroid hormone biosynthesis. After menopause, estrogens are synthesized exclusively in peripheral tissues from circulating steroid precursors, of which the most abundant is ...
Hanna Paatela, Feng Wang, V. Vihma, H. Savolainen-Peltonen, T. Mikkola, U. Turpeinen, E. Hämäläinen, M. Jauhiainen, M. Tikkanen   +8 more
semanticscholar   +1 more source

Primary Alcohol Sulfatase in a Pseudomonas Species [PDF]

, 1965
W. J. A. Payne, Joy P. Williams, W R Mayberry   +2 more
openalex   +1 more source