Results 251 to 260 of about 31,137 (305)
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Expert Opinion on Therapeutic Patents, 2003
AbstractSteroid sulfatase (STS) regulates the local production of estrogens and androgens from systemic precursors in several tissues. The enzyme catalyzes the hydrolysis of the sulfate esters of 3‐hydroxy steroids, which are inactive transport or precursor forms of the active 3‐hydroxy steroids.
Peter, Nussbaumer, Andreas, Billich
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AbstractSteroid sulfatase (STS) regulates the local production of estrogens and androgens from systemic precursors in several tissues. The enzyme catalyzes the hydrolysis of the sulfate esters of 3‐hydroxy steroids, which are inactive transport or precursor forms of the active 3‐hydroxy steroids.
Peter, Nussbaumer, Andreas, Billich
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Chemical Communications, 2020
Herein, a novel two-photon ratiometric fluorescence assay was proposed for monitoring endogenous steroid sulfatase (STS) activity, which could be applied for the ratiometric imaging of STS activity in the endoplasmic reticulum of living cells and tissues
Wei Li +7 more
semanticscholar +1 more source
Herein, a novel two-photon ratiometric fluorescence assay was proposed for monitoring endogenous steroid sulfatase (STS) activity, which could be applied for the ratiometric imaging of STS activity in the endoplasmic reticulum of living cells and tissues
Wei Li +7 more
semanticscholar +1 more source
Rapid degradation of steroid sulfatase in multiple sulfatase deficiency
Biochemical and Biophysical Research Communications, 1986Pulse labeling followed by SDS-PAGE electrophoresis of immunoprecipitated [35S]methionine-labeled steroid sulfatase (STS) gave a single band of molecular weight 65,000 daltons. After a chase period of 18 hours the material appeared as molecular weight approximately 64,000.
A L, Horwitz +3 more
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Biotechnology progress (Print), 2020
Difficult‐to‐express (DTE) recombinant proteins such as multi‐specific proteins, DTE monoclonal antibodies, and lysosomal enzymes have seen difficulties in manufacturability using Chinese hamster ovary (CHO) cells or other mammalian cells as production ...
Ifeanyi Michael Amadi +5 more
semanticscholar +1 more source
Difficult‐to‐express (DTE) recombinant proteins such as multi‐specific proteins, DTE monoclonal antibodies, and lysosomal enzymes have seen difficulties in manufacturability using Chinese hamster ovary (CHO) cells or other mammalian cells as production ...
Ifeanyi Michael Amadi +5 more
semanticscholar +1 more source
Lysosomal sulfatases: a growing family
Biochemical Journal, 2020Sulfatases constitute a family of enzymes that specifically act in the hydrolytic degradation of sulfated metabolites by removing sulfate monoesters from various substrates, particularly glycolipids and glycosaminoglycans. A common essential feature of all known eukaryotic sulfatases is the posttranslational modification of a critical cysteine residue ...
Lübke, Torben, Damme, Markus
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Journal of Steroid Biochemistry, 1974
The conversion of 5-en-3β-ol steroid sulfates to active hormones has been extensively studied. A preliminary desulfation of the precursors is required to allow their structure 5-ene-3β-ol to be transformed to the con-figuration 4-ene-3-keto present in active hormones.
O.V. DOMÍNGUEZ +3 more
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The conversion of 5-en-3β-ol steroid sulfates to active hormones has been extensively studied. A preliminary desulfation of the precursors is required to allow their structure 5-ene-3β-ol to be transformed to the con-figuration 4-ene-3-keto present in active hormones.
O.V. DOMÍNGUEZ +3 more
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2005
Estrogen sulfatase is a microsomal enzyme and is ubiquitously distributed in several mammalian tissues, among which the liver, placenta, and endocrine tissues exhibit relatively high activity. Because the major circulating precursors of estrogen are estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, estrogen sulfatase plays an important role not ...
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Estrogen sulfatase is a microsomal enzyme and is ubiquitously distributed in several mammalian tissues, among which the liver, placenta, and endocrine tissues exhibit relatively high activity. Because the major circulating precursors of estrogen are estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, estrogen sulfatase plays an important role not ...
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Annual Review of Genomics and Human Genetics, 2005
▪ Abstract Sulfatases are a highly conserved family of proteins that cleave sulfate esters from a wide range of substrates. The importance of sulfatases in human metabolism is underscored by the presence of at least eight human monogenic diseases caused by the deficiency of individual sulfatases. Sulfatase activity requires a unique posttranslational
DIEZ ROUX G., BALLABIO, ANDREA
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▪ Abstract Sulfatases are a highly conserved family of proteins that cleave sulfate esters from a wide range of substrates. The importance of sulfatases in human metabolism is underscored by the presence of at least eight human monogenic diseases caused by the deficiency of individual sulfatases. Sulfatase activity requires a unique posttranslational
DIEZ ROUX G., BALLABIO, ANDREA
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Current Opinion in Genetics & Development, 1997
During the past few years, molecular analyses have provided important insights into the biochemistry and genetics of the sulfatase family of enzymes, identifying the molecular bases of inherited diseases caused by sulfatase deficiencies. New members of the sulfatase gene family have been identified in man and other species using a genomic approach ...
PARENTI, GIANCARLO +2 more
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During the past few years, molecular analyses have provided important insights into the biochemistry and genetics of the sulfatase family of enzymes, identifying the molecular bases of inherited diseases caused by sulfatase deficiencies. New members of the sulfatase gene family have been identified in man and other species using a genomic approach ...
PARENTI, GIANCARLO +2 more
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Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase
Biochemical and Biophysical Research Communications, 1988Glucosamine-6-sulfatase is a lysosomal enzyme which degrades glycosaminoglycans and is deficient in mucopolysaccharidosis type IIID. Human liver contains two major active forms of glucosamine-6-sulfatase, form A which has a single 78 kDa polypeptide and form B which has two polypeptides of 48 kDa and 32 kDa.
D A, Robertson +4 more
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