Results 251 to 260 of about 28,914 (292)
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Current Opinion in Genetics & Development, 1997
During the past few years, molecular analyses have provided important insights into the biochemistry and genetics of the sulfatase family of enzymes, identifying the molecular bases of inherited diseases caused by sulfatase deficiencies. New members of the sulfatase gene family have been identified in man and other species using a genomic approach ...
PARENTI, GIANCARLO +2 more
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During the past few years, molecular analyses have provided important insights into the biochemistry and genetics of the sulfatase family of enzymes, identifying the molecular bases of inherited diseases caused by sulfatase deficiencies. New members of the sulfatase gene family have been identified in man and other species using a genomic approach ...
PARENTI, GIANCARLO +2 more
openaire +6 more sources
Expert Opinion on Therapeutic Patents, 2003
AbstractSteroid sulfatase (STS) regulates the local production of estrogens and androgens from systemic precursors in several tissues. The enzyme catalyzes the hydrolysis of the sulfate esters of 3‐hydroxy steroids, which are inactive transport or precursor forms of the active 3‐hydroxy steroids.
Andreas Billich, Peter Nussbaumer
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AbstractSteroid sulfatase (STS) regulates the local production of estrogens and androgens from systemic precursors in several tissues. The enzyme catalyzes the hydrolysis of the sulfate esters of 3‐hydroxy steroids, which are inactive transport or precursor forms of the active 3‐hydroxy steroids.
Andreas Billich, Peter Nussbaumer
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Chemical Communications, 2020
Herein, a novel two-photon ratiometric fluorescence assay was proposed for monitoring endogenous steroid sulfatase (STS) activity, which could be applied for the ratiometric imaging of STS activity in the endoplasmic reticulum of living cells and tissues
Wei Li +7 more
semanticscholar +1 more source
Herein, a novel two-photon ratiometric fluorescence assay was proposed for monitoring endogenous steroid sulfatase (STS) activity, which could be applied for the ratiometric imaging of STS activity in the endoplasmic reticulum of living cells and tissues
Wei Li +7 more
semanticscholar +1 more source
Biotechnology progress (Print), 2020
Difficult‐to‐express (DTE) recombinant proteins such as multi‐specific proteins, DTE monoclonal antibodies, and lysosomal enzymes have seen difficulties in manufacturability using Chinese hamster ovary (CHO) cells or other mammalian cells as production ...
Ifeanyi Michael Amadi +5 more
semanticscholar +1 more source
Difficult‐to‐express (DTE) recombinant proteins such as multi‐specific proteins, DTE monoclonal antibodies, and lysosomal enzymes have seen difficulties in manufacturability using Chinese hamster ovary (CHO) cells or other mammalian cells as production ...
Ifeanyi Michael Amadi +5 more
semanticscholar +1 more source
Annual Review of Genomics and Human Genetics, 2005
▪ Abstract Sulfatases are a highly conserved family of proteins that cleave sulfate esters from a wide range of substrates. The importance of sulfatases in human metabolism is underscored by the presence of at least eight human monogenic diseases caused by the deficiency of individual sulfatases. Sulfatase activity requires a unique posttranslational
DIEZ ROUX G., BALLABIO, ANDREA
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▪ Abstract Sulfatases are a highly conserved family of proteins that cleave sulfate esters from a wide range of substrates. The importance of sulfatases in human metabolism is underscored by the presence of at least eight human monogenic diseases caused by the deficiency of individual sulfatases. Sulfatase activity requires a unique posttranslational
DIEZ ROUX G., BALLABIO, ANDREA
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Rapid degradation of steroid sulfatase in multiple sulfatase deficiency
Biochemical and Biophysical Research Communications, 1986Pulse labeling followed by SDS-PAGE electrophoresis of immunoprecipitated [35S]methionine-labeled steroid sulfatase (STS) gave a single band of molecular weight 65,000 daltons. After a chase period of 18 hours the material appeared as molecular weight approximately 64,000.
Allen L. Horwitz +3 more
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Biochimica et Biophysica Acta (BBA) - Enzymology, 1980
Evidence is presented indicating that three sulfatase activities towards UDP-N-acetylgalactosamine 4-sulfate, nitrocatechol sulfate, and chondroitin 4-sulfate are functions of the same hen oviduct enzyme. Using chondroitin [35S]sulfate from chick embryo cartilage, it is shown that hydrolysis of ester sulfate by this enzyme is limited to 4-sulfate ...
Yasuo Nakanishi +4 more
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Evidence is presented indicating that three sulfatase activities towards UDP-N-acetylgalactosamine 4-sulfate, nitrocatechol sulfate, and chondroitin 4-sulfate are functions of the same hen oviduct enzyme. Using chondroitin [35S]sulfate from chick embryo cartilage, it is shown that hydrolysis of ester sulfate by this enzyme is limited to 4-sulfate ...
Yasuo Nakanishi +4 more
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Journal of Steroid Biochemistry, 1974
The conversion of 5-en-3β-ol steroid sulfates to active hormones has been extensively studied. A preliminary desulfation of the precursors is required to allow their structure 5-ene-3β-ol to be transformed to the con-figuration 4-ene-3-keto present in active hormones.
L.Z. Morán +3 more
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The conversion of 5-en-3β-ol steroid sulfates to active hormones has been extensively studied. A preliminary desulfation of the precursors is required to allow their structure 5-ene-3β-ol to be transformed to the con-figuration 4-ene-3-keto present in active hormones.
L.Z. Morán +3 more
openaire +2 more sources
Developmental regulation of choline sulfatase and aryl sulfatase in Neurospora crassa
Archives of Biochemistry and Biophysics, 1974Abstract Regulation of the synthesis of several enzymes of sulfur metabolism in Neurospora is a function of both metabolic regulation and the genetic control exerted by the cys -3 and scon regulatory genes. Additional control mechanisms appear to regulate the synthesis of choline sulfatase and aryl sulfatase in different developmental stages of ...
William G. McGuire, George A. Marzluf
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Marine Genomics, 2013
The whole genome sequence of Rhodopirellula baltica SH1(T), published nearly 10years ago, already revealed a high amount of sulfatase genes. So far, little is known about the diversity and potential functions mediated by sulfatases in Planctomycetes. We combined in vivo and in silico techniques to gain insights into the ecophysiology of planktomycetal ...
Anna Klindworth +7 more
openaire +3 more sources
The whole genome sequence of Rhodopirellula baltica SH1(T), published nearly 10years ago, already revealed a high amount of sulfatase genes. So far, little is known about the diversity and potential functions mediated by sulfatases in Planctomycetes. We combined in vivo and in silico techniques to gain insights into the ecophysiology of planktomycetal ...
Anna Klindworth +7 more
openaire +3 more sources