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The Journal of Steroid Biochemistry and Molecular Biology, 2007
Sulfatase enzymes have important roles in metabolism of steroid hormones and of glycosaminoglycans (GAGs). The activity of five sulfatase enzymes, including steroid sulfatase (STS; arylsulfatase C), arylsulfatase A (ASA; cerebroside sulfatase), arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase), galactose-6-sulfatase (GALNS), and iduronate-2 ...
Joanne K. Tobacman, Sumit Bhattacharyya
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Sulfatase enzymes have important roles in metabolism of steroid hormones and of glycosaminoglycans (GAGs). The activity of five sulfatase enzymes, including steroid sulfatase (STS; arylsulfatase C), arylsulfatase A (ASA; cerebroside sulfatase), arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase), galactose-6-sulfatase (GALNS), and iduronate-2 ...
Joanne K. Tobacman, Sumit Bhattacharyya
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2005
Estrogen sulfatase is a microsomal enzyme and is ubiquitously distributed in several mammalian tissues, among which the liver, placenta, and endocrine tissues exhibit relatively high activity. Because the major circulating precursors of estrogen are estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, estrogen sulfatase plays an important role not ...
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Estrogen sulfatase is a microsomal enzyme and is ubiquitously distributed in several mammalian tissues, among which the liver, placenta, and endocrine tissues exhibit relatively high activity. Because the major circulating precursors of estrogen are estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, estrogen sulfatase plays an important role not ...
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Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase
Biochemical and Biophysical Research Communications, 1988Glucosamine-6-sulfatase is a lysosomal enzyme which degrades glycosaminoglycans and is deficient in mucopolysaccharidosis type IIID. Human liver contains two major active forms of glucosamine-6-sulfatase, form A which has a single 78 kDa polypeptide and form B which has two polypeptides of 48 kDa and 32 kDa.
John J. Hopwood +4 more
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Multiple Sulfatase Deficiency: A Case Series With a Novel Mutation
Journal of Child Neurology, 2018Multiple sulfatase deficiency is an autosomal recessive lysosomal storage disorder due to a deficiency in formylglycine-generating enzyme, which is encoded by the Sulfatase Modifying Factor 1 (SUMF1) gene. Clinically, the disorder is variable.
Leen O. Hijazi, A. Kashgari, M. Alfadhel
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Synthesis and Stability of Steroid Sulfatase in Fibroblasts from Multiple Sulfatase Deficiency
Biological Chemistry Hoppe-Seyler, 1988Multiple sulfatase deficiency is a lysosomal storage disorder, which can be divided into group I with severe and group II with moderate deficiencies in sulfatases. Antibodies raised against steroid sulfatase purified from human placenta were used to follow the biosynthesis and stability of this enzyme in multiple sulfatase-deficiency fibroblasts ...
Jon T. Conary +2 more
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Metachromatic Leukodystrophy (Sulfatase A Deficiency) and Multiple Sulfatase Deficiency
1975Metachromatic leukodystrophy was first described in adults. Alzheimer (1910) gave a brief abstract of a case which he characterized as a white matter disease with destruction of myelin and abundant, brightly metachromatic deposits in glia cells. Witte (1921) reported similar findings and recognized the accumulation of metachromatic granules in neuronal
Reinhard L. Friede, Reinhard L. Friede
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Properties of sulfatases in cultured skin fibroblasts of multiple sulfatase deficient patients
Clinical Genetics, 1981Various sulfatase activities were assayed in cultured skin fibroblasts from patients with multiple sulfatase deficiency (MSD). MSD cell lines displayed deficiencies of arylsulfatase A and iduronate sulfatase, but activities of arylsulfatase B, N‐acetylgalactosamine 6‐sulfate sulfatase and N‐acetylglucosamine 6‐sulfate sulfatase were within normal ...
Tomochika Kato +4 more
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Synthesis and sulfatase inhibitory activities of non-steroidal estrone sulfatase inhibitors
The Journal of Steroid Biochemistry and Molecular Biology, 1996About one-third of breast cancers are classified as estrogen-dependent breast cancers. In the past 10 years, numerous reports have suggested the importance of estrone sulfate and estrone sulfatase in regulating the supply of estrogens to these cancers. Estrone sulfatase inhibitors may thus prove to be useful for the treatment of these diseases. Several
Pui-Kai Li +3 more
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Multiple Sulfatase Deficiency and the Nature of the Sulfatase Family
2000eighth ...
HOPWOOD J. J, BALLABIO, ANDREA
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The Sulfatase of Ox Liver. IX. The Polymerization of Sulfatase A*
Biochemistry, 1965A. B. Roy, L. W. Nichol
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