Results 61 to 70 of about 14,179 (284)

Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3)

OncoTarget, 2017
The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of ...
S. Bhattacharyya, L. Feferman, J. Tobacman   +2 more
semanticscholar   +1 more source

Expression, activity and localization of lysosomal sulfatases in Chronic Obstructive Pulmonary Disease

Scientific Reports, 2019
Chronic obstructive pulmonary disease (COPD) is a leading cause of death world-wide. Recently, we showed that COPD is associated with gene polymorphisms in SUMF1, a master regulator of sulfatases.
J. Weidner, P. Jogdand, L. Jarenbäck, I. Åberg, Dalja Helihel, J. Ankerst, G. Westergren-Thorsson, L. Bjermer, J. Erjefält, E. Tufvesson   +9 more
semanticscholar   +1 more source

Balanços metabólicos do enxofre em pacientes com leucodistrofia metacromática

Arquivos de Neuro-Psiquiatria, 1968
Foram estudados os balanços metabólicos do enxofre em dois pacientes com a forma juvenil da leucodistrofia metacromática. Foi verificado, em ambos os casos, um balanço positivo desse metaloide, aparentemente não influenciado pelo tipo de dieta (geral ou ...
Horacio M. Canelas, Francisco B. de Jorge, Waldir A. Tognola   +2 more
doaj   +1 more source

Multiple Sulfatase Deficiency (MSD): Review of the Literature and Case Reports of Two Siblings with Dental Caries and Trauma

Case Reports in Pediatrics, 2021
Multiple sulfatase deficiency (MSD) (MIM # 272200) is an extraordinarily rare inborn error of metabolism (IEM). The phenotypic spectrum is largely heterogeneous and attributed to the combined effects of deficiencies in the nine sulfatases currently known
Lorna Hirst, Gehan Abou-Ameira, Mari-Liis Uudelepp   +2 more
doaj   +1 more source

Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling [PDF]

, 2016
The relative roles of SULF1 and SULF2 enzymes in tumour growth are controversial, but short SULF1/SULF2 splice variants predominate in human mammary tumours despite their non-detectable levels in normal mammary tissue. Compared with the normal, the level
Dhoot, G K, Gill, R M S, Mehra, V, Milford, E   +3 more
core   +1 more source

Severe neonatal multiple sulfatase deficiency presenting with hydrops fetalis in a preterm birth patient

JIMD Reports, 2019
Multiple sulfatase deficiency (MSD) is an ultra‐rare lysosomal storage disorder (LSD). Mutations in the SUMF1 gene encoding the formylglycine generating enzyme (FGE) result in an unstable FGE protein with reduced enzymatic activity, thereby affecting the
Lars Schlotawa, Thomas Dierks, Sophie Christoph, Eva Cloppenburg, Andreas Ohlenbusch, G. Christoph Korenke, Jutta Gärtner   +6 more
doaj   +1 more source

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility

Advanced Science, EarlyView.
Cysteine attracts interest due to its unique electrochemical activity and emerging relationship with disulfidptosis. This study develops a new electrochemical nanosensor, which represents the first of its kind capable of detecting intracellular cysteine for various types of tumor cells and primary tumor cells in mice to evaluate disulfidptosis ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
wiley   +1 more source

Proteoglycan desulfation: a critical step in oncogenesis?

Frontiers in Bioscience-Landmark, 2020
Proteoglycans are essential constituents of tissue- and organ microenvironments, modulating both the structural scaffolds that surround cells as well as signaling cues that determine cellular phenotype.
Vishal Singh, Ramray Bhat
doaj   +1 more source

High ultraviolet C resistance of marine Planctomycetes [PDF]

, 2013
Planctomycetes are bacteria with particular characteristics such as internal membrane systems encompassing intracellular compartments, proteinaceous cell walls, cell division by yeast-like budding and large genomes. These bacteria inhabit a wide range of
A Dhawan, A Krisko, A Lieber, A Sancar, AA Arrage, AB Friedrich, AB Friedrich, AP Schuch, B Suter, CB Brachmann, CE Wegner, CS Cockell, CS Cockell, CX Hieu, D Gade, D Hanway, DL Mitchell, EF DeLong, F Azevedo, F Garcia-Pichel, F Joux, Flávia Viana, FO Glöckner, H Schlesner, IS Kulichevskaia, JA Fuerst, JA Fuerst, JA Fuerst, JA Fuerst, JL Fernández, JR Torre de la, KR Kuhlman, LF Batista, M Derakshani, M Hermansson, M Strous, MJ Daly, MM Coxx, N Ward, NP Singh, NP Singh, NS Webster, O Béjà, O Östling, Olga Maria Lage, OM Lage, P Wecker, R Rabus, RP Sinha, Rui Oliveira, S Osman, ZS Kolber   +51 more
core   +1 more source

Mapping molluscan endocrinology: a systematic and critical appraisal

Biological Reviews, EarlyView.
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis, Thomas H. Miller, Olwenn V. Martin, Alice Baynes   +3 more
wiley   +1 more source