Results 81 to 90 of about 14,179 (284)

Action of polystyrene nanoparticles of different sizes on lysosomal function and integrity

Particle and Fibre Toxicology, 2012
Background Data from environmental exposure to nanoparticles (NPs) suggest that chronic exposure may increase the incidence of lung, cardiovascular and neurodegenerative diseases.
Fröhlich Eleonore, Meindl Claudia, Roblegg Eva, Ebner Birgit, Absenger Markus, Pieber Thomas R   +5 more
doaj   +1 more source

Fluorophore Modulates Intracellular Distribution of Enzyme‐Instructed Self‐Assembly of Short Peptides in Osteosarcoma Cells

Small Methods, EarlyView.
Fluorophores at the peptide C‐terminus reprogram EISA behavior in osteosarcoma cellsshifting ER vs mitochondrial targeting, altering assembly, and tuning cytotoxicity. Abstract Enzyme‐instructed self‐assembly (EISA) of peptides offers a versatile strategy for developing intracellular nanomedicines, yet the role of C‐terminus fluorophores in modulating ...
Yali Huang, Meihui Yi, Yuchen Qiao, Bing Xu   +3 more
wiley   +1 more source

Enhanced Tumorigenic Potential of Colorectal Cancer Cells by Extracellular Sulfatases

Molecular Cancer Research, 2014
Heparan sulfate endosulfatase-1 and -2 (SULF1 and SULF2) are two important extracellular 6-O-endosulfatases that remove 6-O sulfate groups of N-glucosamine along heparan sulfate (HS) proteoglycan chains often found in the extracellular matrix.
C. Vicente, M. Lima, E. Yates, H. Nader, L. Toma   +4 more
semanticscholar   +1 more source

Genetic Heterogeneity of Iduronate-2-Sulfatase in Children Diagnosed with Mucopolysaccharidosis Type II in Azerbaijan [PDF]

, 2023
Alizada Sevda Aydin, Aliyeva Kamila Ali Agha, Musayev Shirkhan Aftandil, Rasulov Elkhan, Mammad Rasul   +4 more
openalex   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, EarlyView.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

The multifaceted roles of perlecan in fibrosis [PDF]

, 2018
Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a ...
Al-Ahmad, Andersson-Sjoland, Andersson-Sjoland, Arthur, Ashikari-Hada, Asplund, Aviezer, Barkefors, Barros, Behrens, Beller, Bengtsson, Bingley, Bishop, Bittencourt, Bix, Bix, Borkham-Kamphorst, Bremnes, Burgess, Cailhier, Cassiman, Celie, Ceol, Chakravarti, Chen, Chilosi, Chuang, Chuang, Cohen, Conde-Knape, Conte, Costell, Di Sario, Dos Santos, Duffield, Ebefors, Edgar, Esko, Evanko, Farach-Carson, Farach-Carson, Fengying Tang, Fernandez, Forsberg, Friedman, Friedman, Fujii, Gallai, Garl, Ge, Gellersen, Giros, Gohring, Gonzalez, Gonzalez, Goyal, Gressner, Gubbiotti, Guo, Hajari Case, Hallgren, Hammond, Hashimoto, Haubst, Hayashi, Hayward, Hedin, Hedin, Hering, Hilberg, Hisatomi, Ichimaru, Ikeguchi, Iozzo, Iozzo, Iozzo, Iredale, James G.W. Smith, James Melrose, Jelena Rnjak-Kovacina, John M. Whitelock, Jung, Kahari, Kaji, Kennett, Kinsella, Knox, Knox, Knox, Knox, Kotaru, Kovalszky, Koyama, Krimmer, Kunjathoor, Kvist, Laplante, Laplante, Leask, Leask, Leask, Lee, Lee, Lee, Lekkerkerker, Levy, Liang, Lord, Lord, Lord, Lord, Lundkvist, Mak, Mak, Mak, Malmstrom, Marra, Martinez-Hernandez, Martinez-Hernandez, Marx, Marzoll, Masola, Matsui, Matsuo, Megan S. Lord, Melrose, Melrose, Menzel, Mitra, Mollmark, Mongiat, Mongiat, Moon, Murphy, Musso, Nagy, Nakamura, Nakayama, Narita, Nguyen, Nihlberg, Nilsson, Ogawa, Ohkawara, Ozaki, Paka, Patel, Pillarisetti, Pinzani, Poluri, Pozzi, Raines, Raj, Rauch, Raymond, Rees, Rienstra, Rnjak-Kovacina, Rojkind, Rolls, Rosenzweig, Roskams, Ross, Sahin, Sakai, Salem, Sato, Schaefer, Schafer, Segev, Sharma, Shimizu-Hirota, Singh, Sofroniew, Sweeney, Tang, Tang, Tannock, Tao, Teh, Teimouri, Theret, Thomas, Thyberg, Timpl, Tomasek, Tran, Tran, Tran-Lundmark, Tátrai, Uchimura, Vanheule, Venkatesan, Venkatesan, Wang, Weiser, Weiser, Westergren-Thorsson, Westergren-Thorsson, Westergren-Thorsson, Whitelock, Whitelock, Whitelock, Whitelock, Willis, Wollin, Wollin, Woodall, Xu, Yamamoto, Yang, Yaoi, Yue, Yung, Yung, Zeisberg, Zeisberg   +217 more
core   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Microbial alkyl- and aryl-sulfatases: mechanism, occurrence, screening and stereoselectivities

Applied Microbiology and Biotechnology, 2013
This review gives an overview on the occurrence of sulfatases in Prokaryota, Eukaryota and Archaea. The mechanism of enzymes acting with retention or inversion of configuration during sulfate ester hydrolysis is discussed taking two complementary ...
Michael Toesch, M. Schober, K. Faber
semanticscholar   +1 more source

Methyl Jasmonate Seed Priming Mitigates the Defence‐Growth Trade‐Off and Tailors Plant Response to Specific Pests

Plant, Cell &Environment, EarlyView.
ABSTRACT Seed defence priming is emerging as a novel, cost‐efficient and environmentally safe tool for pest management. It has been proposed as a means to uncouple the defence‐growth trade‐off in plants by enhancing defence responses with minimal fitness costs, but the mechanisms underlying this role remain elusive.
Lucia Talavera‐Mateo, Adrian Sabater‐Gabriel, Alejandro Garcia, Marta Marina Perez‐Alonso, Rayko Halitschke, M. Estrella Santamaria   +5 more
wiley   +1 more source

Nutrient availability affects carbon turnover and microbial physiology differently in topsoil and subsoil under a temperate grassland [PDF]

, 2018
Increasing subsoil organic carbon inputs could potentially mitigate climate change by sequestering atmospheric CO2. Yet, microbial turnover and stabilization of labile carbon in subsoils are regulated by complex mechanisms including the availability of ...
Elsgaard, Lars, Jensen, Johannes L., Liang, Zhi, Olesen, Jørgen E.   +3 more
core   +1 more source