Results 31 to 40 of about 887,382 (298)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Utilizing metakaolin and siliceous waste from the alum industry to create geopolymer adsorbent for the removal of certain heavy metals

Scientific Reports
A geopolymer (GP) from Partially Dealuminated Kaolin (PDK) was synthesized. PDK is a solid waste of alum industry, it was produced in a big quantity, which need careful management to be recycled for protection of the environment against pollution ...
Khaled Elewa, A. F. Tawfic, Mostafa Tarek, Nabil Abdullah Al-Sagheer, Nabil M. Nagy   +4 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Removal of methylene blue from synthetic industrial wastewater by using geopolymer prepared from partially dealuminated metakaolin

Scientific Reports
Industrial wastewater frequently contains a huge of pollutants, such as heavy metals, dyes, and organic compounds, leading to considerable environmental discharge. Methylene Blue (MB), a cationic dye extensively utilized in the textile and pharmaceutical
Khaled Elewa, A. F. Tawfic, Mostafa Tarek, Nabil Abdullah Al-Sagheer, Nabil M. Nagy   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Crystal Structures of Two 1,4-Diamino-1,2,4-triazolium Salts

Crystals, 2016
Bis(1,4-diamino-1,2,4-triazolium) sulfate (1) was obtained from the corresponding chloride by ion metathesis using Ag2SO4. Further metathesis with barium 5,5′-azotetrazolate yielded bis(1,4-diamino-1,2,4-triazolium) 5,5′-azotetrazolate (2). Numerous NH···
Gerhard Laus, Klaus Wurst, Volker Kahlenberg, Herwig Schottenberger   +3 more
doaj   +1 more source

Bis(2-aminobenzimidazolium) sulfate monohydrate

IUCrData, 2022
In the title hydrated molecular salt, 2C7H8N3+·SO42−·H2O, the components are linked by numerous N—H...O and O—H...O hydrogen bonds.
Adrian Peña Hueso, Adriana Esparza Ruiz, Angelina Flores Parra   +2 more
doaj   +1 more source

Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials [PDF]

, 2022
Xiya Zhao, Xu Zhang, Xu Teng, Junjie Luo, Yongting Luo, Peng An   +5 more
openalex   +1 more source