Results 41 to 50 of about 823,047 (268)
Biology, 2013 Fimbriae are long, proteinaceous adhesion organelles expressed on the bacterial envelope, evolutionarily adapted by Escherichia coli strains for the colonization of epithelial linings. Using glycan arrays of the Consortium for Functional Glycomics (CFG),
Manfred Wuhrer +11 more
doaj +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
The role of electron donor in simultaneous degradation of 2,4,6-trichlorophenol and sulfate
上海师范大学学报. 自然科学版, 2020 It is common that industrial wastewater contains 2,4,6-trichlorophenol(TCP) and sulfate simultaneously.Biological reduction is an effective method to remove the pollutants in the wastewater simultaneously.Pyruvic acid was used as an external electron ...
SUN Lizhu, SHEN Yong, WANG Chengqi
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Scientific ReportsIndustrial wastewater frequently contains a huge of pollutants, such as heavy metals, dyes, and organic compounds, leading to considerable environmental discharge. Methylene Blue (MB), a cationic dye extensively utilized in the textile and pharmaceutical
Khaled Elewa +4 more
doaj +1 more source
MicroorganismsSulfide is a toxic and hazardous substance in the agricultural environment, which can cause damage to humans and livestock when exposed to large amounts of air.
Xuechun Wang +5 more
doaj +1 more source
Dimethyl sulfate and diisopropyl sulfate as practical and versatile O-sulfation reagents
Nature CommunicationsAbstractO-Sulfation is a vital post-translational modification in bioactive molecules, yet there are significant challenges with their synthesis. Dialkyl sulfates, such as dimethyl sulfate and diisopropyl sulfate are commonly used as alkylation agents in alkaline conditions, and result in the formation of sulfate byproducts.
Shuaishuai Yue +6 more
openaire +3 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Source Tracing of Sulfate in a Karst Groundwater System in Tai’an City, Shandong Province
Yankuang ceshiIn recent years, the concentration of sulfate in groundwater in northern karst areas has increased significantly, which not only poses a potential threat to human health, but also affects the safety of industrial and agricultural water and the ...
Xiaobo LI +6 more
doaj +1 more source