Results 211 to 220 of about 714,164 (340)

Population Pharmacokinetic Modeling of Glycochenodeoxycholic Acid 3-O-Sulfate (GCDCA-S) as Endogenous Biomarker of OATP1B3 and OAT3 Transporters. [PDF]

Clin Pharmacol Ther
Ujihira Y, Georgiev V, Ogungbenro K, Galetin A.   +3 more
europepmc   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Unusual regulation of the CO₂ concentrating mechanism of marine chemolithoautotroph <i>Thiomicrospira pelophila</i>. [PDF]

Appl Environ Microbiol
Wieschollek J, Payne RR, Morales Alvarez CA, Cisneros N, David H, Dixon C, Grzech H, Oster S, Kasban C, Lunsford C, Mikhaylov J, Nauman N, Dennison CL, Chaput D, Scott K.   +14 more
europepmc   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

An updated sulfate transporter phylogeny uncovers a perennial-specific subgroup associated with lignification. [PDF]

Tree Physiol
Surber SM, Hsieh C, Na L, Harding SA, Tsai CJ.   +4 more
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Deletion of sulfate transporter SUL1 extends yeast replicative lifespan via reduced PKA signaling instead of decreased sulfate uptake. [PDF]

Elife
Long J, Ma M, Chen Y, Gong B, Zheng Y, Li H, Yang J.   +6 more
europepmc   +1 more source

Derepressed Sulfate Transporters Are Strongly and Rapidly Repressed after Sulfate Addition to Sulfur‐Depleted Vitis Cells

INTERNATIONAL JOURNAL PLANT SCIENCES, 2008
S. Tavares, C. Sousa, L. Carvalho, S. Amâncio   +3 more
semanticscholar   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Near-Infrared Triggered Anion Transport Induces Cancer Cell Death. [PDF]

Angew Chem Int Ed Engl
Ahmad M, Devereux RM, Russell AJ, Langton MJ.   +3 more
europepmc   +1 more source