Results 11 to 20 of about 195 (65)

Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant [PDF]

Scientific Reports, 2021
The huge worldwide demand for vaccines targeting SARS-CoV-2 has necessitated the continued development of novel improved formulations capable of reducing the burden of the COVID-19 pandemic. Herein, we evaluated novel protein subunit vaccine formulations
Bassel Akache, Tyler M. Renner, Anh Tran, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Diana Duque, Julie Haukenfrers, Martin A. Rossotti, Francis Gaudreault, Usha D. Hemraz, Edmond Lam, Sophie Régnier, Wangxue Chen, Christian Gervais, Matthew Stuible, Lakshmi Krishnan, Yves Durocher, Michael J. McCluskie   +18 more
doaj   +3 more sources

Simplified Admix Archaeal Glycolipid Adjuvanted Vaccine and Checkpoint Inhibitor Therapy Combination Enhances Protection from Murine Melanoma. [PDF]

Biomedicines, 2019
Archaeosomes are liposomes composed of natural or synthetic archaeal lipids that when used as adjuvants induce strong long-lasting humoral and cell-mediated immune responses against entrapped antigens.
Stark FC, Agbayani G, Sandhu JK, Akache B, McPherson C, Deschatelets L, Dudani R, Hewitt M, Jia Y, Krishnan L, McCluskie MJ.   +10 more
europepmc   +3 more sources

In Silico Prophage Analysis of Halobacterium salinarum ATCC 33170

Applied Microbiology
The extremophile Halobacterium salinarum is an aerobic archaeon that has adapted to thrive in high-salt environments such as salted fish, hypersaline lakes, and salterns. Halophiles have garnered significant interest due to their unique interactions with
Danielle L. Peters, Bassel Akache, Wangxue Chen, Michael J. McCluskie   +3 more
doaj   +3 more sources

Evaluation of the Mode of Action of Sulfated Lactosyl Archaeol Adjuvant: Interaction with L-selectin and Impact of Administration Route

Sulfated lactosyl archaeol (SLA) based semi synthetic archaeosomes are a novel vaccine adjuvant system developed by the National Research Council. There is limited understanding of its mode of action (MOA) and how it interacts with the immune system. SLA
McPherson, Charis Abigail Janeli
core   +4 more sources

Heterologous vs. homologous vaccine regimens: Sulfated lactosyl archaeol (SLA) archaeosome-adjuvanted SARS-CoV-2 spike protein boost following an mRNA/LNP prime induces robust and balanced immune responses

Vaccine
To combat the spread of and disease caused by SARS-CoV-2, mRNA/LNP vaccines were introduced into the clinic in 2020 with tremendous uptake and success. Since then, there have been multiple other SARS-CoV-2 vaccines approved across different countries based on various types of platforms including viral vector, inactivated virus and adjuvanted protein ...
Gérard Agbayani, Lise Deschatelets, Renu Dudani   +2 more
exaly   +4 more sources

Effect of Chiral Purity on Adjuvanticity of Archaeol-Based Glycolipids

Journal of Medicinal Chemistry, 2022
Archaeosomes composed of sulfated lactosyl archaeol (SLA) glycolipids from stereoisomerically pure archaeol (1) are vaccine adjuvants that can boost immunogenicity and vaccine efficacy in preclinical models. Herein, we report a new synthesis of 2,3-bis­((
Vinicio Vasquez (12770823), Blair A. Harrison (6041411), Michael J. McCluskie (9644822), Usha D. Hemraz (1692154), Renu Dudani (6041408), Gerard Agbayani (6041414), Edmond Lam (2686417), Lise Deschatelets (6041405), Bassel Akache (30143), Felicity C. Stark (12770826), Sophie Régnier (1566229), Camilo F. Martinez-Farina (1411444)   +11 more
core   +3 more sources

Two modes of gypsum replacement by carbonate and native sulfur in the Lorca Basin, SE Spain

Frontiers in Earth Science, 2023
Organoclastic sulfate reduction and bacterial sulfide oxidation have been suggested to explain the formation of authigenic carbonate and native sulfur replacing gypsum in the Lorca Basin, Spain.
Simon E. Rouwendaal, D. Birgel, V. Grossi, G. Aloisi, L. Guibourdenche, Amanda L. Labrado, B. Brunner, J. Rouchy, J. Peckmann   +8 more
semanticscholar   +1 more source

Data for: Immunogenicity of SARS-CoV-2 spike antigens derived from Beta & Delta variants of concern

, 2022
Using our strongly immunogenic SmT1 SARS-CoV-2 spike antigen platform, we developed novel antigens based on the Beta & Delta variants of concern. These antigens elicited higher neutralizing antibody activity to the corresponding variant than comparable ...
McCluskie, Michael, Stuible, Matthew, Hill, Jennifer, Regnier, Sophie, Harrison, Blair, Lam, Edmond, Lenferink, Anne, Renner, Tyler, Cepero Donates, Yuneivy, Akache, Bassel, Dudani, Renu, Rohani Larijani, Nazanin, Gervais, Christian, Durocher, Yves, Hemraz, Usha, Deschatelets, Lise   +15 more
core   +1 more source

Synthesis of Galectin Inhibitors by Regioselective 3′-O-Sulfation of Vanillin Lactosides Obtained under Phase Transfer Catalysis

Molecules, 2020
Vanillin-based lactoside derivatives were synthetized using phase-transfer catalyzed reactions from per-O-acetylated lactosyl bromide. The aldehyde group of the vanillin moiety was then modified to generate a series of related analogs having variable ...
Karima Belkhadem, Yihong Cao, R. Roy
semanticscholar   +1 more source

Bis(β-lactosyl)-[60]fullerene as novel class of glycolipids useful for the detection and the decontamination of biological toxins of the Ricinus communis family

Beilstein Journal of Organic Chemistry, 2014
Glycosyl-[60]fullerenes were first used as decontaminants against ricin, a lactose recognition proteotoxin in the Ricinus communis family. A fullerene glycoconjugate carrying two lactose units was synthesized by a [3 + 2] cycloaddition reaction between ...
H. Dohi, T. Kanazawa, A. Saito, Keita Sato, H. Uzawa, Y. Seto, Y. Nishida   +6 more
semanticscholar   +1 more source