The Synergistic Effects of Sulfated Lactosyl Archaeol Archaeosomes When Combined With Different Adjuvants in a Murine Model [PDF]
Pharmaceutics, 2021 Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer.
Usha D Hemraz +2 more
exaly +8 more sources
Sulfated Lactosyl Archaeol Archaeosome-Adjuvanted Vaccine Formulations Targeting Rabbit Hemorrhagic Disease Virus Are Immunogenic and Efficacious [PDF]
Vaccines, 2023 Vaccines play an important role in maintaining human and animal health worldwide. There is continued demand for effective and safe adjuvants capable of enhancing antigen-specific responses to a target pathogen.
Usha D Hemraz +2 more
exaly +7 more sources
Sulfated Lactosyl Archaeol Archaeosomes Synergize With Poly(I:C) To Enhance the Immunogenicity and Efficacy of a Synthetic Long Peptide-Based Vaccine in a Melanoma Tumor Model [PDF]
Pharmaceutics, 2021 Cancer remains a leading cause of morbidity and mortality worldwide. While novel treatments have improved survival outcomes for some patients, new treatment modalities/platforms are needed to combat a wider variety of tumor types. Cancer vaccines harness
Usha D Hemraz +2 more
exaly +8 more sources
Sulfated Lactosyl Archaeol (SLA) Archaeosomes as a Vaccine Adjuvant [PDF]
Human Vaccines and ImmunotherapeuticsArchaeosomes are liposomes traditionally comprised of total polar lipids or semi-synthetic glycerolipids of ether-linked isoprenoid phytanyl cores with varied glycol- and amino-head groups. We have developed a semi-synthetic archaeosome formulation based
Michael J McCluskie, Bassel Akache
exaly +7 more sources
Immunogenicity of Sulfated Lactosyl Archaeol Archaeosome-Adjuvanted Versus Non-Adjuvanted SARS-CoV-2 Spike Booster Vaccines in Young and Aged Balb/c Mice [PDF]
VaccinesBackground/Objectives: The rise of immune escape variants of the SARS-CoV-2 virus has prompted the development of vaccines based on the variant’s spike antigen sequence.
Michael J McCluskie +2 more
exaly +7 more sources
Adjuvanted Schistosoma mansoni-Cathepsin B With Sulfated Lactosyl Archaeol Archaeosomes or AddaVax™ Provides Protection in a Pre-Clinical Schistosomiasis Model [PDF]
Frontiers in Immunology, 2020 Schistosomiasis threatens 800 million people worldwide. Chronic pathology manifests as hepatosplenomegaly, and intestinal schistosomiasis caused by Schistosoma mansoni can lead to liver fibrosis, cirrhosis, and blood in the stool.
Michael J McCluskie +2 more
exaly +6 more sources
Evaluation of Adjuvant Activity and Bio-Distribution of Archaeosomes Prepared Using Microfluidic Technology [PDF]
Pharmaceutics, 2022 Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer.
Michael J McCluskie +2 more
exaly +5 more sources
Tuning the Immune Response: Sulfated Archaeal Glycolipid Archaeosomes as an Effective Vaccine Adjuvant for Induction of Humoral and Cell-Mediated Immunity Towards the SARS-CoV-2 Omicron Variant of Concern [PDF]
Frontiers in Immunology, 2023 Liposomes composed of sulfated lactosyl archaeol (SLA) have been shown to be a safe and effective vaccine adjuvant with a multitude of antigens in preclinical studies.
Sophie Regnier +2 more
exaly +4 more sources
Mechanistic Insight Into the Induction of Cellular Immune Responses by Encapsulated and Admixed Archaeosome-Based Vaccine Formulations [PDF]
Human Vaccines and Immunotherapeutics, 2020 Archaeosomes are liposomes formulated using total polar lipids (TPLs) or semi-synthetic glycolipids derived from archaea. Conventional archaeosomes with entrapped antigen exhibit robust adjuvant activity as demonstrated by increased antigen-specific ...
Usha D Hemraz +2 more
exaly +3 more sources
Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant [PDF]
Scientific Reports, 2021 The huge worldwide demand for vaccines targeting SARS-CoV-2 has necessitated the continued development of novel improved formulations capable of reducing the burden of the COVID-19 pandemic. Herein, we evaluated novel protein subunit vaccine formulations
Bassel Akache +18 more
doaj +2 more sources