Results 1 to 10 of about 257 (80)

Archaeosomes and Gas Vesicles as Tools for Vaccine Development [PDF]

Frontiers in Immunology, 2021
Archaea are prokaryotic organisms that were classified as a new domain in 1990. Archaeal cellular components and metabolites have found various applications in the pharmaceutical industry.
Krzysztof T Krawczyk, Camille Locht, Magdalena Kowalewicz-Kulbat   +2 more
exaly   +4 more sources

Archaeosomes for Oral Drug Delivery: From Continuous Microfluidics Production to Powdered Formulations [PDF]

Pharmaceutics
Archaeosomes were manufactured from natural archaeal lipids by a microfluidics-assisted single-step production method utilizing a mixture of di- and tetraether lipids extracted from Sulfolobus acidocaldarius.
Ruth Prassl, Oliver Spadiut, Julian Quehenberger   +2 more
exaly   +4 more sources

Sulfated lactosyl archaeol (SLA) archaeosomes as a vaccine adjuvant [PDF]

Human Vaccines and Immunotherapeutics
Archaeosomes are liposomes traditionally comprised of total polar lipids or semi-synthetic glycerolipids of ether-linked isoprenoid phytanyl cores with varied glycol- and amino-head groups. We have developed a semi-synthetic archaeosome formulation based
Bassel Akache, Michael J Mccluskie
exaly   +4 more sources

Safety and biodistribution of sulfated archaeal glycolipid archaeosomes as vaccine adjuvants [PDF]

Human Vaccines and Immunotherapeutics, 2018
Archaeosomes are liposomes comprised of ether lipids derived from various archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high pH and thermal stability. As adjuvants, archaeosomes can induce robust, long-lasting humoral and cell-
Bassel Akache, Felicity C Stark, Wangxue Chen   +2 more
exaly   +3 more sources

Evaluation of Adjuvant Activity and Bio-Distribution of Archaeosomes Prepared Using Microfluidic Technology [PDF]

Pharmaceutics, 2022
Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer.
Yimei Jia, Gerard Agbayani, Vandana Chandan, Umar Iqbal, Renu Dudani, Hui Qian, Zygmunt Jakubek, Kenneth Chan, Blair Harrison, Lise Deschatelets, Bassel Akache, Michael J. McCluskie   +11 more
doaj   +2 more sources

The Synergistic Effects of Sulfated Lactosyl Archaeol Archaeosomes When Combined with Different Adjuvants in a Murine Model [PDF]

Pharmaceutics, 2021
Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer.
Yimei Jia, Bassel Akache, Gerard Agbayani, Vandana Chandan, Renu Dudani, Blair A. Harrison, Lise Deschatelets, Usha D. Hemraz, Edmond Lam, Sophie Régnier, Felicity C. Stark, Lakshmi Krishnan, Michael J. McCluskie   +12 more
doaj   +2 more sources

Sulfated Lactosyl Archaeol Archaeosomes Synergize with Poly(I:C) to Enhance the Immunogenicity and Efficacy of a Synthetic Long Peptide-Based Vaccine in a Melanoma Tumor Model [PDF]

Pharmaceutics, 2021
Cancer remains a leading cause of morbidity and mortality worldwide. While novel treatments have improved survival outcomes for some patients, new treatment modalities/platforms are needed to combat a wider variety of tumor types. Cancer vaccines harness
Bassel Akache, Gerard Agbayani, Felicity C. Stark, Yimei Jia, Renu Dudani, Blair A. Harrison, Lise Deschatelets, Vandana Chandan, Edmond Lam, Usha D. Hemraz, Sophie Régnier, Lakshmi Krishnan, Michael J. McCluskie   +12 more
doaj   +2 more sources

Immunogenicity of Sulfated Lactosyl Archaeol Archaeosome-Adjuvanted Versus Non-Adjuvanted SARS-CoV-2 Spike Booster Vaccines in Young and Aged Balb/c Mice [PDF]

Vaccines
Background/Objectives: The rise of immune escape variants of the SARS-CoV-2 virus has prompted the development of vaccines based on the variant’s spike antigen sequence.
Felicity C. Stark, Bassel Akache, Tyler M. Renner, Gerard Agbayani, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Usha D. Hemraz, Sophie Régnier, Matthew Stuible, Yves Durocher, Michael J. McCluskie   +11 more
doaj   +2 more sources

Tuning the immune response: sulfated archaeal glycolipid archaeosomes as an effective vaccine adjuvant for induction of humoral and cell-mediated immunity towards the SARS-CoV-2 Omicron variant of concern [PDF]

Frontiers in Immunology, 2023
Liposomes composed of sulfated lactosyl archaeol (SLA) have been shown to be a safe and effective vaccine adjuvant with a multitude of antigens in preclinical studies.
Tyler M. Renner, Bassel Akache, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Jason Baardsnes, Izel Koyuturk, Jennifer J. Hill, Usha D. Hemraz, Sophie Régnier, Anne E. G. Lenferink, Yves Durocher, Michael J. McCluskie   +15 more
doaj   +2 more sources

Natural carrier systems in cancer vaccines and immunotherapy [PDF]

Human Vaccines & Immunotherapeutics
Cancer, marked by uncontrolled cell growth, is a leading global cause of death. Conventional cancer treatments such as chemotherapy and radiation, for all their use, often come with severe side effects.
Iman Owliaee, Mohammad Shoushtari, Zhina Karimi, Ali Shojaeian   +3 more
doaj   +2 more sources