Results 1 to 10 of about 97 (81)

Archaeosomes and Gas Vesicles as Tools for Vaccine Development [PDF]

Frontiers in Immunology, 2021
Archaea are prokaryotic organisms that were classified as a new domain in 1990. Archaeal cellular components and metabolites have found various applications in the pharmaceutical industry.
Camille Locht, Magdalena Kowalewicz-Kulbat, Krawczyk Krzysztof T   +2 more
exaly   +5 more sources

Safety and biodistribution of sulfated archaeal glycolipid archaeosomes as vaccine adjuvants [PDF]

Human Vaccines and Immunotherapeutics, 2018
Archaeosomes are liposomes comprised of ether lipids derived from various archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high pH and thermal stability. As adjuvants, archaeosomes can induce robust, long-lasting humoral and cell-
Michael Mccluskie, Lakshmi Krishnan, Bassel Akache   +2 more
exaly   +4 more sources

Sulfated lactosyl archaeol (SLA) archaeosomes as a vaccine adjuvant

Human Vaccines and Immunotherapeutics
Archaeosomes are liposomes traditionally comprised of total polar lipids or semi-synthetic glycerolipids of ether-linked isoprenoid phytanyl cores with varied glycol- and amino-head groups. We have developed a semi-synthetic archaeosome formulation based
Michael Mccluskie, Bassel Akache
exaly   +5 more sources

Morphology, biophysical properties and protein-mediated fusion of archaeosomes. [PDF]

PLoS ONE, 2012
As variance from standard phospholipids of eubacteria and eukaryotes, archaebacterial diether phospholipids contain branched alcohol chains (phytanol) linked to glycerol exclusively with ether bonds.
Vid Šuštar, Jasna Zelko, Patrizia Lopalco, Simona Lobasso, Ajda Ota, Nataša Poklar Ulrih, Angela Corcelli, Veronika Kralj-Iglič   +7 more
doaj   +6 more sources

Archaeosomes facilitate storage and oral delivery of cannabidiol

International Journal of Pharmaceutics, 2023
Cannabidiol (CBD) has received great scientific interest due to its numerous therapeutic applications. Degradation in the gastrointestinal (GI) tract, first-pass metabolism, and low water solubility restrain bioavailability of CBD to only 6% in current oral administration. Lipid-based nanocarriers are delivery systems that may enhance accessibility and
Julian Quehenberger, Oliver Spadiut
exaly   +3 more sources

Archaeosomes for Oral Drug Delivery: From Continuous Microfluidics Production to Powdered Formulations

Pharmaceutics
Archaeosomes were manufactured from natural archaeal lipids by a microfluidics-assisted single-step production method utilizing a mixture of di- and tetraether lipids extracted from Sulfolobus acidocaldarius.
Ivan Vidaković, Ruth Prassl, Johannes Khinast   +2 more
exaly   +3 more sources

Ultradeformable Archaeosomes for Needle Free Nanovaccination with Leishmania braziliensis Antigens. [PDF]

PLoS ONE, 2016
Total antigens from Leishmania braziliensis promastigotes, solubilized with sodium cholate (dsLp), were formulated within ultradeformable nanovesicles (dsLp-ultradeformable archaeosomes, (dsLp-UDA), and dsLp-ultradeformable liposomes (dsLp-UDL)) and ...
Leticia H Higa, Laura Arnal, Mónica Vermeulen, Ana Paula Perez, Priscila Schilrreff, Cecilia Mundiña-Weilenmann, Osvaldo Yantorno, María Elena Vela, María José Morilla, Eder Lilia Romero   +9 more
doaj   +5 more sources

The Synergistic Effects of Sulfated Lactosyl Archaeol Archaeosomes When Combined with Different Adjuvants in a Murine Model

Pharmaceutics, 2021
Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer.
Yimei Jia, Bassel Akache, Gerard Agbayani, Vandana Chandan, Renu Dudani, Blair A. Harrison, Lise Deschatelets, Usha D. Hemraz, Edmond Lam, Sophie Régnier, Felicity C. Stark, Lakshmi Krishnan, Michael J. McCluskie   +12 more
doaj   +1 more source

Evaluation of Adjuvant Activity and Bio-Distribution of Archaeosomes Prepared Using Microfluidic Technology

Pharmaceutics, 2022
Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer.
Yimei Jia, Gerard Agbayani, Vandana Chandan, Umar Iqbal, Renu Dudani, Hui Qian, Zygmunt Jakubek, Kenneth Chan, Blair Harrison, Lise Deschatelets, Bassel Akache, Michael J. McCluskie   +11 more
doaj   +1 more source

Sulfated Lactosyl Archaeol Archaeosomes Synergize with Poly(I:C) to Enhance the Immunogenicity and Efficacy of a Synthetic Long Peptide-Based Vaccine in a Melanoma Tumor Model

Pharmaceutics, 2021
Cancer remains a leading cause of morbidity and mortality worldwide. While novel treatments have improved survival outcomes for some patients, new treatment modalities/platforms are needed to combat a wider variety of tumor types. Cancer vaccines harness
Bassel Akache, Gerard Agbayani, Felicity C. Stark, Yimei Jia, Renu Dudani, Blair A. Harrison, Lise Deschatelets, Vandana Chandan, Edmond Lam, Usha D. Hemraz, Sophie Régnier, Lakshmi Krishnan, Michael J. McCluskie   +12 more
doaj   +1 more source