Results 11 to 20 of about 518 (150)

A Spotlight on Archaea in Humans, Livestock and Poultry: A Review [PDF]

Veterinary Medicine and Science
The microbiota includes prokaryotes (archaea and bacteria) and eukaryotes. Archaea are single‐celled prokaryotes and essential part of gut microbiome. Researches on archaea in ruminants and humans are more than mono‐gastric.
Ahmad Salahi, Wafaa A. Abd El‐Ghany
doaj   +3 more sources

Mechanistic insight into the induction of cellular immune responses by encapsulated and admixed archaeosome-based vaccine formulations [PDF]

Human Vaccines & Immunotherapeutics, 2020
Archaeosomes are liposomes formulated using total polar lipids (TPLs) or semi-synthetic glycolipids derived from archaea. Conventional archaeosomes with entrapped antigen exhibit robust adjuvant activity as demonstrated by increased antigen-specific ...
Gerard Agbayani, Yimei Jia, Bassel Akache, Vandana Chandan, Umar Iqbal, Felicity C. Stark, Lise Deschatelets, Edmond Lam, Usha D. Hemraz, Sophie Régnier, Lakshmi Krishnan, Michael J. McCluskie   +11 more
doaj   +3 more sources

Archaeosomes and Tetraether Lipid Liposome [PDF]

Pharmaceutical Sciences and Research, 2012
Archaea have phytanyl ether lipids which is one of the characteristics that separates them from bacteria and eukaryotes. Some archaea have also unique membrane spanning tetrae- ther lipids (T EL); in Sulfolobus and Ihermoplasma species these TELmake up the majority of total membrane lipids.
Freisleben, H. (Hans-Joachim)
core   +3 more sources

Archaeosomes as novel antigen delivery systems

FEMS Microbiology Letters, 1997
The humoral immune response mounted in BALB/c mice against bovine serum albumin or cholera toxin B subunit was compared when the antigens were associated with liposomes composed of either archaeal ether lipids or conventional lipids. Antibody titres in sera from mice immunised intraperitoneally were elevated to an extent comparable to those achieved ...
Sprott, G., Tolson, D., Patel, G.
openaire   +4 more sources

Archaeosomes as Drug and Vaccine Nanodelivery Systems

, 2006
Archaeosomes, liposomes made from the polar lipids extracted from the membranes of Archaea, have been extensively studied for potential applications in drug and vaccine delivery over the past decade only. Archaeosomes offer significant advantages as nanodelivery vesicles over conventional liposomes made from the ester lipids found in Eukarya and ...
Patel, G., Chen, W.
openaire   +3 more sources

Adjuvanted Schistosoma mansoni-Cathepsin B With Sulfated Lactosyl Archaeol Archaeosomes or AddaVax™ Provides Protection in a Pre-Clinical Schistosomiasis Model [PDF]

Frontiers in Immunology, 2020
Schistosomiasis threatens 800 million people worldwide. Chronic pathology manifests as hepatosplenomegaly, and intestinal schistosomiasis caused by Schistosoma mansoni can lead to liver fibrosis, cirrhosis, and blood in the stool.
Dilhan J. Perera, Dilhan J. Perera, Adam S. Hassan, Adam S. Hassan, Yimei Jia, Alessandra Ricciardi, Alessandra Ricciardi, Michael J. McCluskie, Risini D. Weeratna, Momar Ndao, Momar Ndao, Momar Ndao, Momar Ndao   +12 more
doaj   +2 more sources

Morphology, biophysical properties and protein-mediated fusion of archaeosomes. [PDF]

PLoS ONE, 2012
As variance from standard phospholipids of eubacteria and eukaryotes, archaebacterial diether phospholipids contain branched alcohol chains (phytanol) linked to glycerol exclusively with ether bonds.
Vid Šuštar, Jasna Zelko, Patrizia Lopalco, Simona Lobasso, Ajda Ota, Nataša Poklar Ulrih, Angela Corcelli, Veronika Kralj-Iglič   +7 more
doaj   +6 more sources

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research
The growing concerns regarding the immunogenicity of polyethylene glycol (PEG) have prompted the search for alternative excipients that can prolong circulation in parenteral drug delivery.
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
doaj   +2 more sources

Influence of Coenzyme Q10 on Tissue Distribution of Archaeosomes, and Pegylated Archaeosomes, Administered to Mice by Oral and Intravenous Routes

Journal of Drug Targeting, 1999
The biodistribution of orally and intravenously administered archaeosomes in mice was compared to that of archaeosomes containing either coenzyme Q10 (archaeosome-CoQ10), polyethylene glycol (archaeosome-PEG), or PEG plus CoQ10 (archaeosome-PEG-CoQ10).
Omri, A., Makabi-Panzu, B., Agnew, B., Sprott, G., Patel, G.   +4 more
openaire   +4 more sources

The potential of archaeosomes as carriers of pDNA into mammalian cells

Artificial Cells, Nanomedicine, and Biotechnology, 2015
This paper describes the formulation of archaeosomes and the evaluation of their abilities to facilitate in vitro DNA delivery. Lipids of the H.hispanica 2TK2 strain were used in archaeosome formation, which is formulated by mixing H.hispanica 2TK2 lipids with plasmid DNA encoding green fluorescent protein (GFP) or β-galactosidase (β-gal).
Turan, Kadir, Attar, Azade, Yucel, Sevil, Ogan, Ayşe   +3 more
core   +6 more sources