Results 21 to 30 of about 518 (150)
Chemical Biology & Drug Design, 2017 The ability of Archaea to adapt their membrane lipid compositions to extreme environments has brought in archaeosomes into consideration for the development of drug delivery systems overcoming the physical, biological blockades that the body exhibits against drug therapies.
Azade Attar +7 more
core +6 more sources
Human Vaccines & Immunotherapeutics, 2017 Archaeosomes are liposomal vesicles composed of ether glycerolipids unique to the domain of Archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high stability and possess strong adjuvant and immunostimulatory properties making them ...
Michael J. McCluskie +2 more
doaj +2 more sources
Ultradeformable Archaeosomes for Needle Free Nanovaccination with Leishmania braziliensis Antigens. [PDF]
PLoS ONE, 2016 Total antigens from Leishmania braziliensis promastigotes, solubilized with sodium cholate (dsLp), were formulated within ultradeformable nanovesicles (dsLp-ultradeformable archaeosomes, (dsLp-UDA), and dsLp-ultradeformable liposomes (dsLp-UDL)) and ...
Leticia H Higa +9 more
doaj +5 more sources
Cytotoxicity and uptake of archaeosomes prepared from Aeropyrum pernix lipids
Human & Experimental Toxicology, 2013 Archaeon Aeropyrum pernix K1 is an obligate aerobic hyperthermophilic organism with C 25,25 -archeol membrane lipids with head groups containing inositol. Interactions of archaeosomes, liposomes prepared from lipids of A. pernix, with mammalian cells in vitro were studied.
T. B. Napotnik +5 more
openaire +5 more sources
Vaccines, 2016 Homologous prime-boost vaccinations with live vectors typically fail to induce repeated strong CD8+ T cell responses due to the induction of anti-vector immunity, highlighting the need for alternative delivery vehicles. The unique ether lipids of archaea
Felicity C. Stark +2 more
doaj +2 more sources
Archaeosome Immunostimulatory Vaccine Delivery System
Current Drug Delivery, 2005 Archaeosomes are liposomes made from the polar ether lipids of Archaea. These lipids are unique and distinct in structure from the ester lipids found in Eukarya and Bacteria. The regularly branched and usually fully saturated isopranoid chains of archaeal polar lipids are attached via ether bonds to the sn-2,3 carbons of the glycerol backbone(s).
Patel, Girishchandra B., Chen, Wangxue
openaire +4 more sources
SAFETY OF ARCHAEOSOME ADJUVANTS EVALUATED IN A MOUSE MODEL*
Journal of Liposome Research, 2002 Archaeosomes, liposomes prepared from the polar ether lipids extracted from Archaea, demonstrate great potential as immunomodulating carriers of soluble antigens, promoting humoral and cell mediated immunity in the vaccinated host. The safety of unilamellar archaeosomes prepared from the total polar lipids (TPL) of Halobacterium salinarum ...
Patel, G. +3 more
openaire +3 more sources
In vitro evaluation of archaeosome vehicles for transdermal vaccine delivery
Journal of Liposome Research, 2017 Archaeosomes composed of archaeal total polar lipids (TPL) or semi-synthetic analog vesicles have been used as vaccine adjuvants and delivery systems in animal models for many years. Typically administered by intramuscular or subcutaneous injections, archaeosomes can induce robust, long-lasting humoral and cell-mediated immune responses against ...
Yimei Jia +10 more
openaire +3 more sources
Advances in Physicochemical and Biochemical Characterization of Archaeosomes from Polar Lipids of Aeropyrum pernix K1 and Stability in Biological Systems. [PDF]
ACS Omega, 2023 [Image: see text] Archaeosomes are vesicles made from archaeal lipids. They are characterized by remarkable thermostability, resistance to enzymatic degradation, long-term stability, and immunomodulatory properties.
Kejžar J +2 more
europepmc +2 more sources
Polar Lipid Fraction E from Sulfolobus acidocaldarius and Dipalmitoylphosphatidylcholine Can Form Stable yet Thermo-Sensitive Tetraether/Diester Hybrid Archaeosomes with Controlled Release Capability. [PDF]
Int J Mol Sci, 2020 Archaeosomes have drawn increasing attention in recent years as novel nano-carriers for therapeutics. The main obstacle of using archaeosomes for therapeutics delivery has been the lack of an efficient method to trigger the release of entrapped content ...
Ayesa U, Chong PL.
europepmc +2 more sources