Results 21 to 30 of about 478 (150)

Sulfated archaeal glycolipid archaeosomes as a safe and effective vaccine adjuvant for induction of cell-mediated immunity

Human Vaccines & Immunotherapeutics, 2017
Archaeosomes are liposomal vesicles composed of ether glycerolipids unique to the domain of Archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high stability and possess strong adjuvant and immunostimulatory properties making them ...
Michael J. McCluskie, Lise Deschatelets, Lakshmi Krishnan   +2 more
doaj   +2 more sources

Mechanistic insight into the induction of cellular immune responses by encapsulated and admixed archaeosome-based vaccine formulations [PDF]

Human Vaccines & Immunotherapeutics, 2020
Archaeosomes are liposomes formulated using total polar lipids (TPLs) or semi-synthetic glycolipids derived from archaea. Conventional archaeosomes with entrapped antigen exhibit robust adjuvant activity as demonstrated by increased antigen-specific ...
Gerard Agbayani, Yimei Jia, Bassel Akache, Vandana Chandan, Umar Iqbal, Felicity C. Stark, Lise Deschatelets, Edmond Lam, Usha D. Hemraz, Sophie Régnier, Lakshmi Krishnan, Michael J. McCluskie   +11 more
doaj   +2 more sources

Preparation, characterization, and in vitro evaluation of isoniazid and rifampicin‐loaded archaeosomes

Chemical Biology & Drug Design, 2017
The ability of Archaea to adapt their membrane lipid compositions to extreme environments has brought in archaeosomes into consideration for the development of drug delivery systems overcoming the physical, biological blockades that the body exhibits against drug therapies.
Azade Attar, Ceren Bakir, Basak Yuce‐Dursun, Serap Demir, Emrah Cakmakci, Ozkan Danis, Meral Birbir, Ayse Ogan   +7 more
core   +6 more sources

Homologous Prime-Boost Vaccination with OVA Entrapped in Self-Adjuvanting Archaeosomes Induces High Numbers of OVA-Specific CD8+ T Cells that Protect Against Subcutaneous B16-OVA Melanoma

Vaccines, 2016
Homologous prime-boost vaccinations with live vectors typically fail to induce repeated strong CD8+ T cell responses due to the induction of anti-vector immunity, highlighting the need for alternative delivery vehicles. The unique ether lipids of archaea
Felicity C. Stark, Michael J. McCluskie, Lakshmi Krishnan   +2 more
doaj   +2 more sources

SAFETY OF ARCHAEOSOME ADJUVANTS EVALUATED IN A MOUSE MODEL*

Journal of Liposome Research, 2002
Archaeosomes, liposomes prepared from the polar ether lipids extracted from Archaea, demonstrate great potential as immunomodulating carriers of soluble antigens, promoting humoral and cell mediated immunity in the vaccinated host. The safety of unilamellar archaeosomes prepared from the total polar lipids (TPL) of Halobacterium salinarum ...
Patel, G., Omri, A., Deschatelets, Lise, Sprott, G.   +3 more
openaire   +3 more sources

Archaeosome Immunostimulatory Vaccine Delivery System

Current Drug Delivery, 2005
Archaeosomes are liposomes made from the polar ether lipids of Archaea. These lipids are unique and distinct in structure from the ester lipids found in Eukarya and Bacteria. The regularly branched and usually fully saturated isopranoid chains of archaeal polar lipids are attached via ether bonds to the sn-2,3 carbons of the glycerol backbone(s).
Patel, Girishchandra B., Chen, Wangxue
openaire   +4 more sources

Archaeosomes display immunoadjuvant potential for a vaccine against Chagas disease [PDF]

Human Vaccines & Immunotherapeutics, 2013
Archaeosomes (ARC), vesicles made from lipids extracted from Archaea, display strong adjuvant properties. In this study, we evaluated the ability of the highly stable ARC formulated from total polar lipids of a new Halorubrum tebenquichense strain found in Argentinean Patagonia, to act as adjuvant for soluble parasite antigens in developing ...
Higa, Leticia Herminia, Corral, Ricardo Santiago, Morilla, María José, Romero, Eder Lilia, Petray, Patricia Beatriz   +4 more
openaire   +5 more sources

Surviving nebulization-induced Stress: Dexamethasone in pH-sensitive Archaeosomes [PDF]

Nanomedicine, 2016
To increase the subcellular delivery of dexamethasone phosphate (DP) and stability to nebulization stress, pH-sensitive nanoliposomes (LpH) exhibiting archaeolipids, acting as ligands for scavenger receptors (pH-sensitive archaeosomes [ApH]), were prepared.The anti-inflammatory effect of 0.18 mg DP/mg total lipid, 100-150 nm DP-containing ApH ...
Altube, María Julia, Selzer, Solange Mailen, de Farias, Marcelo Alexandre, Portugal, Rodrigo Villares, Morilla, María José, Romero, Eder Lilia   +5 more
openaire   +4 more sources

Cytotoxicity and uptake of archaeosomes prepared from Aeropyrum pernix lipids

Human & Experimental Toxicology, 2013
Archaeon Aeropyrum pernix K1 is an obligate aerobic hyperthermophilic organism with C 25,25 -archeol membrane lipids with head groups containing inositol. Interactions of archaeosomes, liposomes prepared from lipids of A. pernix, with mammalian cells in vitro were studied.
T. B. Napotnik, J. Valant, D. Gmajner, PASSAMONTI, SABINA, D. Miklavcic, N. P. Ulrih   +5 more
openaire   +5 more sources

Archaeosomes made of Halorubrum tebenquichense total polar lipids: a new source of adjuvancy [PDF]

BMC Biotechnology, 2009
Background Archaeosomes (ARC), vesicles prepared from total polar lipids (TPL) extracted from selected genera and species from the Archaea domain, elicit both antibody and cell-mediated immunity to the entrapped antigen, as well as efficient cross ...
Morilla Maria, Corral Ricardo S, Roncaglia Diana I, Morelli Irma, Bilen Marcos, Cutrullis Romina A, Higa Leticia H, Gonzalez Raul O, Petray Patricia B, Romero Eder L   +9 more
doaj   +2 more sources