Results 31 to 40 of about 478 (150)

In vitro evaluation of archaeosome vehicles for transdermal vaccine delivery

Journal of Liposome Research, 2017
Archaeosomes composed of archaeal total polar lipids (TPL) or semi-synthetic analog vesicles have been used as vaccine adjuvants and delivery systems in animal models for many years. Typically administered by intramuscular or subcutaneous injections, archaeosomes can induce robust, long-lasting humoral and cell-mediated immune responses against ...
Yimei Jia, Michael J. McCluskie, Dongling Zhang, Robert Monette, Umar Iqbal, Maria Moreno, Janelle Sauvageau, Dean Williams, Lise Deschatelets, Zygmunt J. Jakubek, Lakshmi Krishnan   +10 more
openaire   +3 more sources

Advances in Physicochemical and Biochemical Characterization of Archaeosomes from Polar Lipids of Aeropyrum pernix K1 and Stability in Biological Systems. [PDF]

ACS Omega, 2023
[Image: see text] Archaeosomes are vesicles made from archaeal lipids. They are characterized by remarkable thermostability, resistance to enzymatic degradation, long-term stability, and immunomodulatory properties.
Kejžar J, Osojnik Črnivec IG, Poklar Ulrih N.   +2 more
europepmc   +2 more sources

Polar Lipid Fraction E from Sulfolobus acidocaldarius and Dipalmitoylphosphatidylcholine Can Form Stable yet Thermo-Sensitive Tetraether/Diester Hybrid Archaeosomes with Controlled Release Capability. [PDF]

Int J Mol Sci, 2020
Archaeosomes have drawn increasing attention in recent years as novel nano-carriers for therapeutics. The main obstacle of using archaeosomes for therapeutics delivery has been the lack of an efficient method to trigger the release of entrapped content ...
Ayesa U, Chong PL.
europepmc   +2 more sources

First Isolation and Structure Elucidation of GDNT‐β‐Glu – Tetraether Lipid Fragment from Archaeal Sulfolobus Strains

ChemistryOpen, Volume 10, Issue 9, Page 889-895, September 2021., 2021
The isolation and structure elucidation of a tetraether lipid (TEL) fragment GDNT‐β‐Glu occurring in Sulfolobus strains are described. The investigations reveal new knowledge regarding the binding relationships which is also important for the general structure determination of intact TEL.
Alexander Scholte, Christoph Hübner, Dieter Ströhl, Olaf Scheufler, Steffen Czich, Julia M. Börke, Gerhard Hildebrand, Klaus Liefeith   +7 more
wiley   +1 more source

Nanoparticle‐based applications for cervical cancer treatment in drug delivery, gene editing, and therapeutic cancer vaccines

WIREs Nanomedicine and Nanobiotechnology, Volume 13, Issue 5, September/October 2021., 2021
Recent progresses in nanoparticle‐based delivery systems show potential foreground for enhancing clinical benefits while minimizing systemic toxicities in cervical cancer. Abstract Cervical cancer is a leading cause of gynecological tumor related deaths worldwide.
Peijie Zhou, Wei Liu, Yong Cheng, Dong Qian   +3 more
wiley   +1 more source

Targeted Nanotherapeutics for Respiratory Diseases: Cancer, Fibrosis, and Coronavirus

Advanced Therapeutics, Volume 4, Issue 2, February 2021., 2021
Targeted delivery of nanotherapeutics specifically to diseased lungs, pulmonary cells, and/or specific organelles offers distinct advantages over systemic delivery by enhancing efficacy of the treatment and limiting severe adverse side effects. Nanoscale based systems can transport various types of payload, simultaneously carry out several distinct ...
Joydeb Majumder, Tamara Minko
wiley   +1 more source

The Polar Lipid Fraction E from Sulfolobus acidocaldarius Can Be Used as Liposomal Drug Stabilizing Agents to Reduce the Leakage of the Antivascular Drug Combretastatin A4 Disodium Phosphate from Tetraether/Diester Hybrid Archaeosomes

Biophysica, 2021
Liposomes have many advantages as therapeutic capsules over free drugs such as small molecule drugs and nucleic acids. Cholesterol is commonly used as a membrane stabilizing agent in liposomal drugs (e.g., mRNA-lipid nanoparticle COVID-19 vaccines ...
Varsha P. Daswani, Umme Ayesa, Parkson Lee-Gau Chong   +2 more
doaj   +1 more source

Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents. [PDF]

Int J Hypertens
The lipid‐based drug delivery system (LBDDS) is a well‐established technique that is anticipated to bring about comprehensive transformations in the pharmaceutical field, impacting the management and administration of drugs, as well as treatment and diagnosis.
Preeti, Sambhakar S, Malik R, Bhatia S, Harrasi AA, Saharan R, Aggarwal G, Kumar S, Sehrawat R, Rani C.   +9 more
europepmc   +2 more sources

Delivery systems for natural antioxidant compounds: Archaeosomes and archaeosomal hydrogels characterization and release study

International Journal of Pharmaceutics, 2011
The aim of this study was to use archaeosomes, a novel kind of liposomes made up by archaeal polar lipids, both multilamellars (MLVs) and unilamellars (SUVs), as a topical delivery system for natural antioxidant compounds recovered from olive mill waste. For comparative purpose an analogue formulation of phosphatidylcholine liposomes was prepared. SUVs
Ana, González-Paredes, Beatriz, Clarés-Naveros, María Adolfina, Ruiz-Martínez, Juan José, Durbán-Fornieles, Alberto, Ramos-Cormenzana, Mercedes, Monteoliva-Sánchez   +5 more
openaire   +3 more sources

TLR Agonist Augments Prophylactic Potential of Acid Inducible Antigen Rv3203 against Mycobacterium tuberculosis H37Rv in Experimental Animals. [PDF]

PLoS ONE, 2016
In general, the members of Lip gene family of Mycobacterium tuberculosis evoke strong immune response in the host. Keeping this fact into consideration, we investigated role of Rv3203, a cell wall associated protein with lipolytic activity, in imparting ...
Owais Mohammad, Jagdeep Kaur, Gurpreet Singh, Syed Mohd Faisal, Asim Azhar, Mohd Ahmar Rauf, Umesh Dutt Gupta, Pushpa Gupta, Rahul Pal, Swaleha Zubair   +9 more
doaj   +1 more source