Results 31 to 40 of about 518 (150)

First Isolation and Structure Elucidation of GDNT‐β‐Glu – Tetraether Lipid Fragment from Archaeal Sulfolobus Strains

ChemistryOpen, Volume 10, Issue 9, Page 889-895, September 2021., 2021
The isolation and structure elucidation of a tetraether lipid (TEL) fragment GDNT‐β‐Glu occurring in Sulfolobus strains are described. The investigations reveal new knowledge regarding the binding relationships which is also important for the general structure determination of intact TEL.
Alexander Scholte, Christoph Hübner, Dieter Ströhl, Olaf Scheufler, Steffen Czich, Julia M. Börke, Gerhard Hildebrand, Klaus Liefeith   +7 more
wiley   +1 more source

Nanoparticle‐based applications for cervical cancer treatment in drug delivery, gene editing, and therapeutic cancer vaccines

WIREs Nanomedicine and Nanobiotechnology, Volume 13, Issue 5, September/October 2021., 2021
Recent progresses in nanoparticle‐based delivery systems show potential foreground for enhancing clinical benefits while minimizing systemic toxicities in cervical cancer. Abstract Cervical cancer is a leading cause of gynecological tumor related deaths worldwide.
Peijie Zhou, Wei Liu, Yong Cheng, Dong Qian   +3 more
wiley   +1 more source

Targeted Nanotherapeutics for Respiratory Diseases: Cancer, Fibrosis, and Coronavirus

Advanced Therapeutics, Volume 4, Issue 2, February 2021., 2021
Targeted delivery of nanotherapeutics specifically to diseased lungs, pulmonary cells, and/or specific organelles offers distinct advantages over systemic delivery by enhancing efficacy of the treatment and limiting severe adverse side effects. Nanoscale based systems can transport various types of payload, simultaneously carry out several distinct ...
Joydeb Majumder, Tamara Minko
wiley   +1 more source

The Polar Lipid Fraction E from Sulfolobus acidocaldarius Can Be Used as Liposomal Drug Stabilizing Agents to Reduce the Leakage of the Antivascular Drug Combretastatin A4 Disodium Phosphate from Tetraether/Diester Hybrid Archaeosomes

Biophysica, 2021
Liposomes have many advantages as therapeutic capsules over free drugs such as small molecule drugs and nucleic acids. Cholesterol is commonly used as a membrane stabilizing agent in liposomal drugs (e.g., mRNA-lipid nanoparticle COVID-19 vaccines ...
Varsha P. Daswani, Umme Ayesa, Parkson Lee-Gau Chong   +2 more
doaj   +1 more source

Ultradeformable archaeosomes as new topical adjuvants

Nanomedicine: Nanotechnology, Biology and Medicine, 2012
Ultradeformable archaeosomes (UDA) are vesicles made of soybean phosphatidylcholine (SPC), sodium cholate (NaChol) and polar lipids from Halorubrum tebenquichense (3:1:3 wt/wt). Although ultradeformable liposomes (UDL, made of SPC and NaChol at 6:1 wt/wt) and UDA were neither captured nor caused cytotoxicity on keratinocytes, UDA was avidly captured by
Higa, Leticia Herminia, Schilrreff, Priscila, Perez, Ana Paula, Iriarte, Maiara A., Roncaglia, Diana Inés, Morilla, María José, Romero, Eder Lilia   +6 more
openaire   +6 more sources

TLR Agonist Augments Prophylactic Potential of Acid Inducible Antigen Rv3203 against Mycobacterium tuberculosis H37Rv in Experimental Animals. [PDF]

PLoS ONE, 2016
In general, the members of Lip gene family of Mycobacterium tuberculosis evoke strong immune response in the host. Keeping this fact into consideration, we investigated role of Rv3203, a cell wall associated protein with lipolytic activity, in imparting ...
Owais Mohammad, Jagdeep Kaur, Gurpreet Singh, Syed Mohd Faisal, Asim Azhar, Mohd Ahmar Rauf, Umesh Dutt Gupta, Pushpa Gupta, Rahul Pal, Swaleha Zubair   +9 more
doaj   +1 more source

Delivery systems for natural antioxidant compounds: Archaeosomes and archaeosomal hydrogels characterization and release study

International Journal of Pharmaceutics, 2011
The aim of this study was to use archaeosomes, a novel kind of liposomes made up by archaeal polar lipids, both multilamellars (MLVs) and unilamellars (SUVs), as a topical delivery system for natural antioxidant compounds recovered from olive mill waste. For comparative purpose an analogue formulation of phosphatidylcholine liposomes was prepared. SUVs
Ana, González-Paredes, Beatriz, Clarés-Naveros, María Adolfina, Ruiz-Martínez, Juan José, Durbán-Fornieles, Alberto, Ramos-Cormenzana, Mercedes, Monteoliva-Sánchez   +5 more
openaire   +3 more sources

Synthesis of Paclitaxel Loaded on Nanoparticles of Archaeosomes and Investigation of Its Anti-cancer Properties

Asian Pacific Journal of Cancer Biology, 2017
Objective: In this study, the effect of archaeosomal paclitaxel drug on breast cancer MDA-MB231 cell lines was evaluated. Material and method: The experiments were conducted to assess the cytotoxicity of paclitaxel in free form and compare it with ...
Maral Mazloumi Tabrizi, Sepideh Jafarzadeh Rastin, Nahid Kabiri, Azim Akbarzadeh Khiyavi   +3 more
doaj   +1 more source

Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents. [PDF]

Int J Hypertens
The lipid‐based drug delivery system (LBDDS) is a well‐established technique that is anticipated to bring about comprehensive transformations in the pharmaceutical field, impacting the management and administration of drugs, as well as treatment and diagnosis.
Preeti, Sambhakar S, Malik R, Bhatia S, Harrasi AA, Saharan R, Aggarwal G, Kumar S, Sehrawat R, Rani C.   +9 more
europepmc   +2 more sources

Archaeosome Adjuvant Overcomes Tolerance to Tumor-Associated Melanoma Antigens Inducing Protective CD8+ T Cell Responses

Clinical and Developmental Immunology, 2010
Vesicles comprised of the ether glycerolipids of the archaeon Methanobrevibacter smithii (archaeosomes) are potent adjuvants for evoking CD8+ T cell responses.
Lakshmi Krishnan, Lise Deschatelets, Felicity C. Stark, Komal Gurnani, G. Dennis Sprott   +4 more
doaj   +1 more source