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Transient Sulfenic Acids in the Synthesis of Biologically Relevant Products [PDF]
Molecules, 2018 Sulfenic acids as small molecules are too unstable to be isolated and their transient nature offers the possibility to involve them in concerted processes that lead to the obtainment of functional groups such as sulfoxides, sulfones, and disulfides.
Anna Barattucci +4 more
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Cysteine-based redox regulation and signalling in plants [PDF]
Frontiers in Plant Science, 2013 Living organisms are subjected to oxidative stress conditions which are characterized by the production of reactive oxygen (ROS), nitrogen (RNS) and sulfur (RSS) species.
Jérémy eCouturier +3 more
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Formation, reactivity, and detection of protein sulfenic acids. [PDF]
Chem Res Toxicol, 2010 It has become clear in recent decades that the post-translational modification of protein cysteine residues is a crucial regulatory event in biology. Evidence supports the reversible oxidation of cysteine thiol groups as a mechanism of redox-based signal transduction, while the accumulation of proteins with irreversible thiol oxidations is a hallmark ...
Kettenhofen NJ, Wood MJ.
europepmc +4 more sources
Redox Biology, 2021 Cysteine sulfenic acids (Cys-SOH) are pivotal modifications in thiol-based redox signaling and central intermediates en route to disulfide and sulfinic acid states.
Yunlong Shi, Kate S. Carroll
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Cysteinyl and methionyl redox switches: Structural prerequisites and consequences
Redox Biology, 2023 Redox modifications of specific cysteinyl and methionyl residues regulate key enzymes and signal-transducing proteins in various pathways. Here, we analyzed the effect of redox modifications on protein structure screening the RCSB protein data bank for ...
Yana Bodnar, Christopher Horst Lillig
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Isolable small-molecule cysteine sulfenic acid
Chemical Communications, 2021 A small-molecule cysteine sulfenic acid (Cys–SOH) with ‘shelf stability’ protected by a molecular cradle was synthesized by direct oxidation of a thiol with H2O2. Its crystal structure and biologically relevant reactivity were elucidated.
Tsukasa Sano +3 more
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Antioxidants, 2020 In this communication we demonstrate that two natural isothiocyanates, sulforaphane (SFN) and erucin (ERN), inhibit autoxidation of lipids at 140 °C but not below 100 °C.
Jakub Cedrowski +3 more
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Frontiers in Cell and Developmental Biology, 2022 The involvement of peroxisomes in cellular hydrogen peroxide (H2O2) metabolism has been a central theme since their first biochemical characterization by Christian de Duve in 1965.
Celien Lismont +11 more
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Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression. [PDF]
PLoS ONE, 2009 Akt is a serine/threonine kinase involved in cell proliferation, apoptosis, and glucose metabolism. Akt is differentially activated by growth factors and oxidative stress by sequential phosphorylation of Ser(473) by mTORC2 and Thr(308) by PDK1.
Valeria Gabriela Antico Arciuch +6 more
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Journal of Fungi, 2021 Antithrombotic thienopyridines, such as clopidogrel and prasugrel, are prodrugs that undergo a metabolic two-step bioactivation for their pharmacological efficacy.
Jan Kiebist +9 more
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