Results 71 to 80 of about 7,062 (200)

How are proteins reduced in the endoplasmic reticulum? [PDF]

, 2018
The reversal of thiol oxidation in proteins within the endoplasmic reticulum (ER) is crucial for protein folding, degradation, chaperone function, and the ER stress response. Our understanding of this process is generally poor but progress has been made.
Bulleid, Neil, Ellgaard, Lars, Sevier, Carolyn S.   +2 more
core   +2 more sources

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

Redox regulation of methylthioadenosine phosphorylase in liver cells: molecular mechanism and functional implications [PDF]

, 2008
MTAP (5'-methylthioadenosine phosphorylase) catalyses the reversible phosphorolytic cleavage of methylthioadenosine leading to the production of methylthioribose-1-phosphate and adenine.
Avila, M.A. (Matías Antonio), Corrales, F.J. (Fernando José), Fernandez-Irigoyen, J. (Joaquín), Latasa, M.U. (María Ujué), Muñoz, J. (Javier), Prieto, J. (Jesús), Sanchez-del-Pino, M.M. (Manuel M.), Sanchez-Quiles, V. (Virginia), Santamaria, E. (Enrique), Santamaria, M. (Mónica), Valero, M.L. (María L.)   +10 more
core   +1 more source

NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease

Advanced Science, Volume 12, Issue 42, November 13, 2025.
CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee, Seunghwan Sim, Yinglan Jin, Hyejun Park, Eun Young Byeon, Su Jin Kim, Sujin Yun, Hye Eun Lee, Da Un Jeong, Jung Min Suh, In Hye Lee, Ho‐Young Lee, Yongseok Choi, Yun Soo Bae   +13 more
wiley   +1 more source

Subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins based on catalytic activity. [PDF]

, 2013
© American Chemical Society,2010. Post-print version of article deposited in accordance with SHERPA RoMEO guidelinesPeroxiredoxins are ubiquitous proteins that catalyze the reduction of hydroperoxides, thus conferring resistance to oxidative stress ...
Brown, Alan R, Campopiano, DJ, Clarke, DJ, Govan, JR, Langridge-Smith, P, Mackay, CL, Ortega, XP, Valvano, MA   +7 more
core   +1 more source

Oxidative stress in wild‐derived and cultivated peanut genotypes caused by heat stress at flowering

Agronomy Journal, Volume 117, Issue 6, November/December 2025.
Abstract Peanut (Arachis hypogaea L.) is a globally important crop; however, its productivity is increasingly threatened by heat stress, exacerbated by global warming. Developing heat‐tolerant peanuts is crucial for sustainable production amidst rising temperatures.
Kelvin Jimmy Awori, Soraya Leal‐Bertioli, David Bertioli, Viktor Tishchenko, Gabrielle Alves Comitre, Cristiane Pilon   +5 more
wiley   +1 more source

8-Oxoguanine DNA Glycosylase-1 Augments Proinflammatory Gene Expression by Facilitating the Recruitment of Site-Specific Transcription Factors [PDF]

, 2014
Among the insidious DNA base lesions, 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant, a lesion that arises through the attack by reactive oxygen species on guanine, especially when located in cis-regulatory elements.
Aguilera-Aguirre, Leopoldo, Ba, Xueqing, Boldogh, István, Brasier, Allan R., Bácsi, Attila, Luo, Jixian, Radak, Zsolt, Zeng, Xianlu   +7 more
core   +1 more source

Influence of the Concentration of Different Amino Acids on the Corrosion Behavior of Mg Alloy AZ31—A Respirometric Study

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 11, November 2025.
ABSTRACT In view of the potential use of Mg‐based materials as biodegradable metals in temporary implantation, it is important to study the role of different components of the biological environment on the corrosion behavior. This work focuses on the effect of selected amino acids and their concentrations on time‐dependent corrosion of Mg alloy AZ31 ...
M. P. Bruns, G. Schulze, M. G. Strebl, S. Virtanen   +3 more
wiley   +1 more source

Unraveling the Catalytic Mechanism of Nitrile Hydratases [PDF]

, 2007
To elucidate a detailed catalytic mechanism for nitrile hydratases (NHases), the pH and temperature dependence of the kinetic constants kcat and Km for the cobalt-type NHase from Pseudonocardia thermophila JCM 3095 (PtNHase) were examined.
Holz, Richard C., Mitra, Sanghamitra
core   +1 more source

Active focal segmental glomerulosclerosis is associated with massive oxidation of plasma albumin [PDF]

, 2007
The basic mechanism for idiopathic FSGS still is obscure. Indirect evidence in humans and generation of FSGS by oxidants in experimental models suggest a role of free radicals.
BRUSCHI M, CANDIANO G, CARIDI G, DEL BOCCIO P, DIMASI N, F. SCOLARI, GALLIANO M, GHIGGERI GM, MUSANTE L, PAVONE B, PETRETTO A, URBANI A, VINCENTI F   +12 more
core   +1 more source