Oxidative denaturation of Cu/Zn‐superoxide dismutase associated with neurodegenerative diseases
Protein Science, Volume 34, Issue 11, November 2025.Abstract Misfolding of mutant Cu/Zn‐superoxide dismutase (SOD1) is a well‐established pathological feature of familial amyotrophic lateral sclerosis (ALS). While amino acid substitutions in mutant SOD1 destabilize its structure and promote misfolding, oxidation has also been implicated in the pathological alterations of wild‐type SOD1, particularly in ...
Moeno Yoshida +9 more
wiley +1 more source
Principles for integrating reactive species into in vivo biological processes:examples from exercise physiology [PDF]
, 2015 The equivocal role of reactive species and redox signaling in exercise responses and adaptations is an example clearly showing the inadequacy of current redox biology research to shed light on fundamental biological processes in vivo.
Cobley, James N. +6 more
core +3 more sources
Proteomics in drug hypersensitivity [PDF]
, 2016 21 p.-4 fig.-1 tab.Drug hypersensitivity reactions result from the activation of the immune system by drugs or their metabolites. The clinical presentations of drug hypersensitivity can range from relatively mild local manifestations to severe systemic ...
Aldini, Giancarlo +4 more
core +1 more source
Regulation of Redox Signaling by Selenoproteins [PDF]
, 2010 The unique chemistry of oxygen has been both a resource and threat for life on Earth for at least the last 2.4 billion years. Reduction of oxygen to water allows extraction of more metabolic energy from organic fuels than is possible through anaerobic ...
Wayne Chris Hawkes, Zeynep Alkan
core +1 more source
Strained Cycloalkynes as New Protein Sulfenic Acid Traps
Journal of the American Chemical Society, 2014 Protein sulfenic acids are formed by the reaction of biologically relevant reactive oxygen species with protein thiols. Sulfenic acid formation modulates the function of enzymes and transcription factors either directly or through the subsequent formation of protein disulfide bonds.
Poole, Thomas H. +5 more
openaire +2 more sources
Characterization of the Arabidopsis thaliana 2-Cys peroxiredoxin interactome [PDF]
, 2016 This document is the Accepted Manuscript of the following article: Delphine Cerveau, et al, ‘Characterization of the Arabidopsis thaliana 2-Cys peroxiredoxin interactome’, Plant Science, Vol. 252, pp.
Ahn +92 more
core +4 more sources
Measurement and clinical significance of biomarkers of oxidative stress in humans [PDF]
, 2017 Oxidative stress is the result of the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidants. Biomarkers of oxidative stress are relevant in the evaluation of the disease status and of the health-enhancing ...
Altieri, Fabio +2 more
core +3 more sources
Analyzing the Catalytic Mechanism of the Fe-Type Nitrile Hydratase from \u3cem\u3eComamonas testosteroni\u3c/em\u3e Ni1 [PDF]
, 2008 In order to gain insight into the catalytic mechanism of Fe-type nitrile hydratases (NHase), the pH and temperature dependence of the kinetic parameters kcat, Km, and kcat/Km along with the solvent isotope effect were examined for the Fe-type NHase from ...
Holz, Richard C., Rao, Saroja
core +1 more source
S-Glutathionylation at Cys328 and Cys542 Impairs STAT3 Phosphorylation. [PDF]
, 2014 STAT3 is a latent transcription factor that promotes cell survival and proliferation and is often constitutively active in cancers. Although many reports provide evidence that STAT3 is a direct target of oxidative stress, its redox regulation is poorly ...
Andres R. M. +47 more
core +1 more source
Isotopic tagging of oxidized and reduced cysteines (iTORC) for detecting and quantifying sulfenic acids, disulfides, and free thiols in cells. [PDF]
J Biol Chem, 2019 Albertolle ME +3 more
europepmc +1 more source