Parsing protein sulfinic acid switches
Nature Chemical Biology, 2018 The proteome-wide application of a probe that selectively labels cysteine residues oxidized to the sulfinic acid form reveals the mammalian S-sulfinylome and uncovers novel substrates of the sulfinyl reductase sulfiredoxin, opening yet unexplored realms of cysteine-based redox regulation.
Rahuel-Clermont, Sophie +1 more
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Converging Fate of the Oxidation and Reduction of 8-Thioguanosine
Molecules, 2019 Thione-containing nucleobases have attracted the attention of the scientific community for their application in oncology, virology, and transplantology.
Katarzyna Taras-Goslinska +5 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 2009 Human serum albumin (HSA) is the most abundant protein in the intravascular compartment. It possesses a single thiol, Cys34, which constitutes ~80% of the total thiols in plasma. This thiol is able to scavenge plasma oxidants.
L. Turell +4 more
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Irreversible Thiol Oxidation in Carbonic Anhydrase III: Protection by S-Glutathiolation and Detection in Aging Rats [PDF]
, 2002 Proteins with reactive sulfhydryls are central to many important metabolic reactions and also contribute to a variety of signal transduction systems. In this re- port, we examine the mechanisms of oxidative dam- age to the two reactive sulfhydryls of ...
Hamann, Michael +6 more
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The Interaction of Hypotaurine and Other Sulfinates with Reactive Oxygen and Nitrogen Species:A Survey of Reaction Mechanisms [PDF]
, 2017 Considerable strides have been made in understanding the oxidative mechanisms involved in the final steps of the cysteine pathway leading to taurine.
A Baseggio Conrado +38 more
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The sulfenylation of imidazopyridines with sulfinic acids mediated by DTBP/HCl
Results in ChemistryA direct sulfenylation reaction of imidazopyridines with sulfinic acid mediated by di-tert-butylperoxide (DTBP) and hydrochloric acid was developed leading to the introduction of CS bonds into the imidazo[1,2-a]pyridine skeleton.
Yu Wang +6 more
doaj +1 more source
Journal of Lipid Research, 1999 Oxidative modification of LDL may be important in the initiation and/or progression of atherosclerosis, but the precise mechanisms through which low density lipoprotein (LDL) is oxidized are unknown.
Chao-yuh Yang +7 more
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The Impact of Simulation Sequencing on Perceived Clinical Decision Making [PDF]
, 2017 An emerging nursing education trend is to utilize simulated learning experiences as a means to optimize competency and decision making skills. The purpose of this study was to examine differences in students\u27 perception of clinical decision making and
Hansen, Jamie +3 more
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Metabolism of the Antituberculosis Drug Ethionamide [PDF]
, 2013 Ethionamide (ETH) is an important second-line antituberculosis drug used for the treatment of patients infected with multidrug-resistant Mycobacterium. Although ETH is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated
Helder A Santos, Nuno Vale, Paula Gomes
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Multiple States of Nitrile Hydratase from Rhodococcus equi TG328-2: Structural and Mechanistic Insights from Electron Paramagnetic Resonance and Density Functional Theory Studies [PDF]
, 2017 Iron-type nitrile hydratases (NHases) contain an Fe(III) ion coordinated in a characteristic “claw setting” by an axial cysteine thiolate, two equatorial peptide nitrogens, the sulfur atoms of equatorial cysteine-sulfenic and cysteine-sulfinic acids, and
Stein, Natalia +9 more
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