Results 91 to 100 of about 86,041 (331)

New Heteroleptic Ruthenium(II) Complexes with Sulfamethoxypyridazine and Diimines as Potential Antitumor Agents

Molecules, 2019
Two new complexes of Ru(II) with mixed ligands were prepared: [Ru(bpy)2smp](PF6) (1) and [Ru(phen)2smp](PF6) (2), in which smp = sulfamethoxypyridazine; bpy = 2,2′-bipyridine; phen = 1,10-phenanthroline.
Ariane C.C. de Melo, Jaime M.S.V.P. Santana, Kelen J.R.C. Nunes, Bernardo L. Rodrigues, Nathalia Castilho, Philipe Gabriel, Adolfo H. Moraes, Mayra de A. Marques, Guilherme A.P. de Oliveira, Ívina P. de Souza, Hernán Terenzi, Elene C. Pereira-Maia   +11 more
doaj   +1 more source

N-Vinylation of Aromatic Sulfonamides Using Calcium Carbide as a Concise Solid Alkyne Source

, 2023
Liao Haiyan, Zheng Li
openalex   +1 more source

Medicare Part D and Hospital Admissions due to Antimicrobial Resistance

Health Economics, EarlyView.
ABSTRACT Antimicrobial resistance (AMR) has been increasing rapidly in the United States despite government efforts to contain its spread. Both under‐utilization and overuse of prescribed antimicrobials contribute to rising resistance. The introduction of Medicare Part D in 2006 expanded prescription drug coverage for the elderly, including coverage ...
Ricardo B. Ang III
wiley   +1 more source

Design, Synthesis, and Structural Evolution of Pseudo-Natural Product IDO1 Inhibitors and Degraders. [PDF]

Angew Chem Int Ed Engl
The combination of bicyclic monoterpene‐ and pyrrolidine‐alkaloid fragments yields novel pseudo‐natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of indoleamine‐2,3‐dioxygenase. Abstract Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties.
Cheng XF, Lucas B, Lampe P, Ugel S, Chen S, Unger A, Bischoff M, Adariani SR, Naredla KR, Kumar K, Schmidt A, Strohmann C, Janning P, Gasper R, Lucas M, Gersch M, Sievers S, Bronte V, Ziegler S, Waldmann H.   +19 more
europepmc   +3 more sources

Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The present work describes the design and synthesis of a novel series of 1,3-diaryl-4-sulfonamidoarylpyrazole derivatives 1a–q and 2a–q and their in vitro biological activities.
Mohammed S. Abdel-Maksoud, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din, Chang Hyun Oh   +3 more
doaj   +1 more source

A study of mono-, di- and tri-tosylated amines: An unexpected sulfonamide [PDF]

, 2023
M. John Plater, William T. A. Harrison
openalex   +1 more source

Antimicrobial sulfonamide drugs

, 2017
Sulfonamides are the first successfully synthesized antimicrobial drugs. The mechanism of sulfonamides antimicrobial action involves competitive inhibition of folic acid synthesis which prevents the growth and reproduction of microorganisms.
Ana Tačić, V. Nikolić, L. Nikolić, I. Savić   +3 more
semanticscholar   +1 more source

Pursing Quinoline-8-Sulfonamide derivatives for the identification of potent NPPs inhibitors: In silico molecular docking, molecular dynamics simulations and density field theory (DFT) studies

Results in Chemistry
Nucleotide pyrophosphatase/phosphodiesterase (NPP) enzymes belong to a broad category of ectonucleotidase enzymes. These NPPs are responsible for hydrolysis of extracellular nucleotides (ATP to AMP) and are therefore important regulators in the ...
Jamshed Iqbal, Talha Islam, Mariya al-Rashida, Abdul Hameed, Taseer Iftikhar, Julie Pelletier, Jean Sévigny, Salman Alrokayan, Maria Maqbool, Khurshid Ayub, Tajamul Hussain   +10 more
doaj   +1 more source

Formal Synthesis of the Akuammiline Alkaloid (±)‐Strictamine via a (4 + 2) Annulation Reaction With a Donor–Acceptor Cyclobutane

Helvetica Chimica Acta, EarlyView.
We report a concise formal synthesis of (±)‐strictamine via a silylium‐catalyzed (4 + 2) annulation of a donor–acceptor cyclobutane, achieved in 13 steps from tryptamine. ABSTRACT The akuammiline alkaloids are complex monoterpene indole natural products with a rigid cage‐like architecture and diverse biological activities.
Clément Tanguy, Emma G. L. Robert, Jerome Waser   +2 more
wiley   +1 more source

Thermodynamic study of the solubility of some sulfonamides in cyclohexane [PDF]

, 2003
Fleming Martínez, Carolina M. Ávila, Alfredo Gómez   +2 more
openalex   +1 more source