Results 91 to 100 of about 77,925 (335)

Effect of Pyrolysis on the Removal of Antibiotic Resistance Genes and Class I Integrons from Municipal Wastewater Biosolids [PDF]

, 2018
Wastewater biosolids represent a significant reservoir of antibiotic resistance genes (ARGs). While current biosolids treatment technologies can reduce ARG levels in residual wastewater biosolids, observed removal rates vary substantially.
Kappell, Anthony D., Kimbell, Lee, McNamara, Patrick J.   +2 more
core   +1 more source

A New Synthetic Route to Original Sulfonamide Derivatives in 2-Trichloromethylquinazoline Series: A Structure-Activity Relationship Study of Antiplasmodial Activity

Molecules, 2012
We report herein a simple and efficient two-step synthetic approach to new 2-trichloromethylquinazolines possessing a variously substituted sulfonamide group at position 4 used to prepare new quinazolines with antiparasitic properties.
Nadine Azas, Sylvain Rault, Pascal Rathelot, Sébastien Hutter, Aurélien Dumètre, Charline Kieffer, Anita Cohen, Pierre Verhaeghe, Nicolas Primas, Patrice Vanelle   +9 more
doaj   +1 more source

Asymmetric additions to dienes catalysed by a dithiophosphoric acid. [PDF]

, 2011
Chiral Brønsted acids (proton donors) have been shown to facilitate a broad range of asymmetric chemical transformations under catalytic conditions without requiring additional toxic or expensive metals.
Hamilton, Gregory, Rauniyar, Vivek, Shapiro, Nathan, TOSTE, F. Dean, Wu, Jeffrey   +4 more
core   +2 more sources

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Assessment of the antiproliferative and apoptotic roles of sulfonamide carbonic anhydrase IX inhibitors in HeLa cancer cell line

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Carbonic anhydrase IX (CA IX) has recently been validated as an antitumor/antimetastatic drug target. In this study, we examined the underlying molecular mechanisms and the anticancer activity of sulfonamide CA IX inhibitors against cervical cancer cell ...
Ismail Koyuncu, Ataman Gonel, Mustafa Durgun, Abdurrahim Kocyigit, Ozgur Yuksekdag, Claudiu T. Supuran   +5 more
doaj   +1 more source

Genomic comparison of diverse Salmonella serovars isolated from swine. [PDF]

, 2019
Food animals act as a reservoir for many foodborne pathogens. Salmonella enterica is one of the leading pathogens that cause food borne illness in a broad host range including animals and humans.
Barrett, John B, Frye, Jonathan G, Gupta, Sushim K, Hiott, Lari M, Humayoun, Shaheen B, Jackson, Charlene R, McClelland, Michael, McMillan, Elizabeth A, Sharma, Poonam, Woodley, Tiffanie   +9 more
core   +2 more sources

Streamlining SuFEx Inhibitor Development: A Unified Approach Using Photolabile and Orthogonal Sulfinate Protecting Groups

Angewandte Chemie International Edition, Accepted Article.
Sulfonyl fluorides have gained significant importance due to their classification as a click reaction and therefore have seen increased use in drug discovery and biochemistry. Their use, however, is complicated by the methods by which they are synthesized and their general synthetic instability.
Twinkle I Patel, Makayla Williams, Ramkrishna Laha, Yumeng Chi, Matthew Moschitto   +4 more
wiley   +1 more source

Neuropharmacological Assessment of Sulfonamide Derivatives of Para-Aminobenzoic Acid through In Vivo and In Silico Approaches

Drugs and Drug Candidates
Background/Objectives: Alzheimer’s disease (AD), a complex neurogenerative disorder, manifests as dementia and concomitant neuropsychiatric symptoms, including apathy, depression, and circadian disruption.
Ankit Ganeshpurkar, Ravi Singh, Pratigya Tripathi, Qadir Alam, Sairam Krishnamurthy, Ashok Kumar, Sushil Kumar Singh   +6 more
doaj   +1 more source

Synthesis and molecular docking studies of some 4-phthalimidobenzenesulfonamide derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A series of 4-phthalimidobenzenesulfonamide derivatives were designed, synthesized and evaluated for the inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).
Zeynep Soyer, Sirin Uysal, Sulunay Parlar, Ayse Hande Tarikogullari Dogan, Vildan Alptuzun   +4 more
doaj   +1 more source

Nurses\u27 Alumnae Association Bulletin - Volume 3 Number 5 [PDF]

, 1944
Jefferson Marches On Christmas Packages The United States Cadet Nurse Corps and Jefferson Medical College Hospital Attention Promotions Welcome, Miss Hopkins Student Nurse Activities Scholarship Girls Taking Anaesthesia Our Office and Teaching Staff ...
Elliott, Margaret, Knowles, H. J
core   +1 more source