Results 101 to 110 of about 114,841 (367)

Crystal structure of 5,5′-bis(dimethylamino)-N,N′-(3-methyl-3-azapentane-1,5-diyl)di(naphthalene-1-sulfonamide)

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C29H37N5O4S2, two arms substituted with dansyl derivatives are connected to a central tertiary amine, where the dihedral angle between the planes of two dansyl units is 56.39 (4)°.
Toyketa V. Horne, Syed A. Haque, Adrianne Barton, Md. Alamgir Hossain   +3 more
doaj   +1 more source

FMNH2-dependent monooxygenases initiate catabolism of sulfonamides in Microbacterium sp. strain BR1 subsisting on sulfonamide antibiotics

Scientific Reports, 2017
We report a cluster of genes encoding two monooxygenases (SadA and SadB) and one FMN reductase (SadC) that enable Microbacterium sp. strain BR1 and other Actinomycetes to inactivate sulfonamide antibiotics.
B. Ricken, B. Kolvenbach, Christian Bergesch, D. Benndorf, K. Kroll, H. Strnad, Č. Vlček, R. Adaixo, F. Hammes, P. Shahgaldian, A. Schäffer, H. Kohler, P. Corvini   +12 more
semanticscholar   +1 more source

Resistance to trimethoprim and sulfonamides [PDF]

Veterinary Research, 2001
Sulfonamides and trimethoprim have been used for many decades as efficient and inexpensive antibacterial agents for animals and man. Resistance to both has, however, spread extensively and rapidly. This is mainly due to the horizontal spread of resistance genes, expressing drug-insensitive variants of the target enzymes dihydropteroate synthase and ...
openaire   +4 more sources

Acylsulfonamide safety-catch linker : promise and limitations for solid-phase oligosaccharide synthesis [PDF]

, 2012
Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated ...
Collot, M., Eller, S., Seeberger, P., Yin, J.   +3 more
core   +2 more sources

Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Hayreddin Gezegen, Oguz Özbek, Meryem Topal, Hatice Şahin, Ümit M. Koçyiğit   +4 more
wiley   +1 more source

Crystal structure of N,N-diisopropyl-4-methylbenzenesulfonamide

Acta Crystallographica Section E: Crystallographic Communications, 2020
The synthesis of the title compound, C13H21NO2S, is reported here along with its crystal structure. This compound crystallizes with two molecules in the asymmetric unit. The sulfonamide functional group of this structure features S=O bond lengths ranging
Brock A. Stenfors, Richard J. Staples, Shannon M. Biros, Felix N. Ngassa   +3 more
doaj   +1 more source

Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. [PDF]

, 2018
Interactions of drug molecules with lipid membranes play crucial role in their accessibility of cellular targets and can be an important predictor of their therapeutic and safety profiles.
Bekker, Slava, Clancy, Colleen E, DeMarco, Kevin R, Noskov, Sergei Y, Vorobyov, Igor   +4 more
core  

Exploring quinolinone–chalcones: Synthesis, antioxidant potential and industrial applications in biofuels

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Biofuels undergo oxidative degradation, which reduces their storage stability and efficiency, hindering their large‐scale adoption and integration into the global energy matrix. To address this issue, we synthesized and characterized four novel quinolinone–chalcone derivatives (substituted with Br, Cl, OCH3 and OCH2CH3) as potential ...
Vitor S. Duarte, Renata Layse G. de Paula, Leonardo R. Almeida, Giulio D. C. D’Oliveira, Caridad N. Pérez, Jean M. F. Custódio, Valter H. Carvalho‐Silva, Andrea Lombardi, Hamilton B. Napolitano   +8 more
wiley   +1 more source

Safety of sulfamethoxazole–trimethoprim for the treatment of bacterial infection in outpatient settings: A systematic review and meta‐analysis with active comparator disproportionality analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra, Lujain Ez Eddin, Fatemeh Ahmadi, Atefeh Jafari, Flory T. Muanda   +4 more
wiley   +1 more source

A New Synthetic Route to Original Sulfonamide Derivatives in 2-Trichloromethylquinazoline Series: A Structure-Activity Relationship Study of Antiplasmodial Activity

Molecules, 2012
We report herein a simple and efficient two-step synthetic approach to new 2-trichloromethylquinazolines possessing a variously substituted sulfonamide group at position 4 used to prepare new quinazolines with antiparasitic properties.
Nadine Azas, Sylvain Rault, Pascal Rathelot, Sébastien Hutter, Aurélien Dumètre, Charline Kieffer, Anita Cohen, Pierre Verhaeghe, Nicolas Primas, Patrice Vanelle   +9 more
doaj   +1 more source