Results 191 to 200 of about 50,577 (283)

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source

In Silico Decoding of Nonsteroidal Mineralocorticoid Receptor Antagonist Binding: Implications for Drug Design. [PDF]

J Chem Inf Model
Pérez-Gordillo F, Carpio LE, Alvarez de la Rosa D, Martín-Martínez M.   +3 more
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Anthraquinone Sulfonamide and Carboxamide Analogs: Cytotoxicity and Preliminary HDAC-Modulating Effects. [PDF]

ACS Omega
Prathumchat J, Pitchuanchom S, Leerat C, Namwan N, Senawong G, Senawong T, Phaosiri C, Nontakitticharoen M.   +7 more
europepmc   +1 more source

Acute-onset bilateral myopia induced by hydrochlorothiazide. [PDF]

Einstein (Sao Paulo)
Zimmermann LM, Resende JMA, Castro H, Barcellos RB.   +3 more
europepmc   +1 more source

Developmental Toxicity Study for the Antimalarial Drug Combination Cabamiquine‐Pyronaridine Using a Translational Approach

Birth Defects Research, Volume 118, Issue 10, October 2026.
ABSTRACT Background The safety of pharmacological treatments during pregnancy is a significant concern, as many medications lack comprehensive reproductive safety data. This creates gaps in therapeutic options for pregnant women, particularly malaria, which poses serious risks to maternal and fetal health.
Wookyung Kim, Geum‐Sil Cho, Andreas Gado, Tobias Hyun Ho Baeurle, Habib Karimi, Filippo Venezia, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, Claudia Demarta‐Gatsi   +9 more
wiley   +1 more source

Isolation and Characterization of Two Perfluorobutane Sulfonamide (FBSA)-Degrading Bacterial Strains, <i>Neobacillus</i> sp. LH-1 and <i>Glutamicibacter</i> sp. BO-1, from Estuarine and Marine Sediments. [PDF]

Toxics
Zhao C, Feng M, Wang K, Gao Y, Zhao J, Zhao S.   +5 more
europepmc   +1 more source

Oxidative Generation and Reactivity of the Cyclopropyl Radical From a Martin Silicate

Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.
A photoredox strategy employing Martin silicates enables the oxidative generation and controlled capture of cyclopropyl radicals, including the naked one, long considered challenging intermediates. The method affords functionalized cyclopropanes through both Giese‐type additions and dual nickel/photoredox C(sp3)−C(sp2) cross‐couplings.
Amal Lakhal, Alexandre Millanvois, Louis Fensterbank, Cyril Ollivier   +3 more
wiley   +1 more source

Affinity-Activated Protein Switches for Modular and Signal-ON Detection of Small Molecules. [PDF]

Anal Chem
Wu CC, Chen HM, Chang TJ, Weng LL, Wang YC, Chao KC, Lin JC, Jian BL, Chu LA, Tan KT.   +9 more
europepmc   +1 more source

Sodium Hypochlorite Pentahydrate in Organic Synthesis and Beyond

Chemistry–Methods, Volume 6, Issue 10, October 2026.
Sodium hypochlorite pentahydrate emerges as a versatile, stable, and practical oxidant for organic synthesis. This review highlights its unique reactivity, broad synthetic applications, and growing impact on sustainable oxidation chemistry, providing a comprehensive overview of recent advances and future opportunities. Sodium hypochlorite pentahydrate (
Masayuki Kirihara, Hideyuki Tsutsui, Yoshikazu Kimura   +2 more
wiley   +1 more source

Systemic Medications as Triggers of Acute Angle-Closure Glaucoma: A Narrative Review. [PDF]

J Clin Med
Alarfaj M, Qedair J.
europepmc   +1 more source