Results 91 to 100 of about 7,119 (254)

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Manganese-catalyzed cyclopropanation of allylic alcohols with sulfones

Nature Communications
Cyclopropanes are among the most important structural units in natural products, pharmaceuticals, and agrochemicals. Herein, we report a manganese-catalyzed cyclopropanation of allylic alcohols with sulfones as carbene alternative precursors via a ...
Ke Yu, Qin Nie, Qianjin Chen, Weiping Liu   +3 more
doaj   +1 more source

Relay Approach: A Convergent Synthesis of Key Fragments en route to (+)‐Neosorangicin A

Chemistry – A European Journal, EarlyView.
A selective synthesis of three key fragments of the antibiotically active (+)‐neosorangicin A is reported, providing a foundation for its convergent total synthesis and proof of strategy via a relay approach. ABSTRACT Herein, we report the synthesis of the three key fragments of the macrolide antibiotic (+)‐neosorangicin A, a compound exhibiting potent
Marvin Wenninger, Maxim Munt, Le Chang, Rositsa Stoykova, Roberto Ojcius, Oliver Spieß, Dieter Schinzer   +6 more
wiley   +1 more source

Zinc Promoted Cross‐Electrophile Sulfonylation to Access Alkyl–Alkyl Sulfones

Advanced Science
The transition metal‐catalyzed multi‐component cross‐electrophile sulfonylation, which incorporates SO2 as a linker within organic frameworks, has proven to be a powerful, efficient, and cost‐effective means of synthesizing challenging alkyl–alkyl ...
Zhuochen Wang, Rui Ma, Chang Gu, Xiaoqian He, Haiwei Shi, Ruopeng Bai, Renyi Shi   +6 more
doaj   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Photoinduced ROS Production by Poly(3‐hexylthiophene) (P3HT) is due to Autoxidation Rather Than Catalysis

Chemistry – A European Journal, EarlyView.
P3HT is widely treated as a photocatalyst that generates ROS under light. We show otherwise: ROS production comes at the expense of the polymer itself. Photoexcited P3HT acts as a self‐sacrificial photosubstrate, undergoing irreversible autoxidation during light‐driven oxygen reduction—a distinction critical for interpreting its behavior in emerging ...
Roman Gańczarczyk, Renata Rybakiewicz‐Sekita, Eric D. Głowacki   +2 more
wiley   +1 more source

Redox‐Tuned Oxycarbamates Enable Divergent C─N and C─C Functionalization of Indolizines Under Photoredox Catalysis With Green Light

Chemistry – A European Journal, EarlyView.
Nonafluoromesitylsulfonyl (Nms)‐substituted oxycarbamates are introduced as redox‐lowered radical precursors for green‐light photoredox synthesis. Selective N─O bond cleavage generates amidyl radicals that directly aminate indolizines in DMF, whereas DMSO promotes 1,2‐hydrogen atom transfer (HAT) to α‐amino carbon‐centered radicals and C─C bond ...
Kevin Klaus Stefanoni, René Wilhelm
wiley   +1 more source

Infrared Irradiation‐Assisted Pd‐Catalyzed C(sp3)─H Arylation and Tandem Cyclization of Ortho‐Tolualdehydes

Chemistry – A European Journal, EarlyView.
A rapid and efficient protocol for the synthesis of 2‐benzylbenzaldehydes and anthracenes is reported, based on the infrared (IR) irradiation‐assisted Pd‐catalyzed C(sp3)─H arylation and the tandem C(sp3)─H arylation/electrophilic aromatic cyclization of ortho‐tolualdehydes with aryl iodides via a transient directing group (TGD) strategy.
Matteo Renato Martina, Ambra Maria Fiore, Angela Punzi, Gianluigi Albano, Roberta Ragni, Pietro Cotugno, Gianluca Maria Farinola   +6 more
wiley   +1 more source

Self‐Immolative Poly(Benzyl Ether)s: Design Principles and Controlled Depolymerization

Chemistry – A European Journal, EarlyView.
Unzipping to Sustainability: This Concept article explores the thermodynamic design of quinone‐methide (QM)‐based poly(benzyl ether)s (PBEs). It explains how a low ceiling temperature (Tc), QM stability, and an entropic gain drive rapid depolymerization (“unzipping”) of PBEs into monomers.
Ji Woo Kim, Yewon Kang, Hyungwoo Kim
wiley   +1 more source

Low‐Temperature in Situ Upgrading of Ultra‐Deep Heavy Oil Using Ni–Ce/MOF–OTf Superacid Catalysts to Enhance Energy Utilization and Sustainability

EcoEnergy, EarlyView.
A triflate‐functionalized Ni–Ce/MOF–OTf superacid enables low‐temperature (∼140°C) in situ upgrading of ultra‐deep heavy oil. It reduces viscosity by 92.11% in 12 h, maintains activity over cycles, and delivers 90.25% recovery with a lower carbon footprint by selective bond cleavage. ABSTRACT Ultra‐deep heavy oil is an important unconventional resource,
Li Wang, Ji‐Xiang Guo, Qiming Huang, Kunpeng Li, Chi Li, Yajie Wu   +5 more
wiley   +1 more source