Results 71 to 80 of about 7,119 (254)

Synthesis, Biological Evaluation and Molecular Docking of Certain Sulfones as Potential Nonazole Antifungal Agents

Molecules, 2016
We reported herein the synthesis, antifungal activity, docking and in silico ADME prediction studies of four novel series of sulfones 6a–f, 8a–c, 10a–f and 12a–c.
Mohamed Fares, Mohamed A. Said, Muhammad A. Alsherbiny, Radwa A. Eladwy, Hadia Almahli, Marwa M. Abdel-Aziz, Hazem A. Ghabbour, Wagdy M. Eldehna, Hatem A. Abdel-Aziz   +8 more
doaj   +1 more source

Vinyl sulfones: selective and tunable covalent warheads against challenging enzyme targets [PDF]

Exploration of Drug Science
Over the past several decades there has been a growing recognition of the role that covalent drug candidates have played in the drug development process. With this recognition, compounds that are capable of selectively and irreversibly inactivating their
Ronald E. Viola
doaj   +1 more source

Electrochemical oxidations of thioethers: Modulation of oxidation potential using a hydrogen bonding network

Electrochemistry Communications, 2019
A highly efficient chemo-selective electrochemical oxidation of thioethers to sulfoxides and sulfones was developed. The hydrogen bonding network generated from hexafluoro-2-propanol (HFIP) and acetic acid (AcOH) plays an important role in the modulation
Shiwen Liu, Bocheng Chen, Yi Yang, Yuhao Yang, Qianjin Chen, Xiaojun Zeng, Bo Xu   +6 more
doaj   +1 more source

Unified Synthesis of Unconventional α‐Polyhalogenated Amines Through Hydroaminoalkylation

Angewandte Chemie International Edition, EarlyView.
A unified, redox‐neutral method that transforms alkenes and alkynes into α‐polyhalomethyl amines using stable hemiaminal reagents is reported. This approach enables access to CF3, CF2H, CF2Cl, and CFClH motifs, expanding halogenated amine space with broad substrate scope, functional group tolerance, and applicability to late‐stage modification of drug ...
Angela K. Hofmeister, Giulia Iannelli, Péter Angyal, Augustin Malandain, Daniel Kaiser, Boris Maryasin, Hanspeter Kählig, Matteo Barel, Gaia Novarino, Nuno Maulide   +9 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Synthesis of New 10-Arylthioanthralins and Oxidation of Thioanthralins to Their Corresponding Sulfones [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1996
Treatment of 10-bromoanthralin (1) with several thiophenols (2) gave the corresponding 10-arylthioanthralins (3) in high yields. Oxidation of thioanthralins (3a-c) and (3k-m) using an excess of m-chloroperbenzoic acid gave the corresponding sulfones (4a ...
Jabbar Khalafy, John Malcolm Pruce
doaj  

Synthesis and Elastase Inhibitory Evaluation of Phosphate Esters and Mixed Phosphate Anhydride of Penam Sulfones

Molecules, 2000
The evaluation of human leucocite elastase inhibition by phosphate esters (1-2) and phosphate mixed anhydride (3) of penicillin sulfones and their precursor sulfides is described.
O. A. Mascaretti, María A. Laborde   +1 more
doaj   +1 more source

Modulation of Properties in [1]Benzothieno[3,2-b][1]benzothiophene Derivatives through Sulfur Oxidation

Molecules
This study explores the impact of sulfur oxidation on the structural, optical, and electronic properties of [1]benzothieno[3,2-b][1]benzothiophene (BTBT) derivatives, specifically focusing on 2,7-dibromo BTBT (2,7-diBr-BTBT) and its oxidized forms, 5,5 ...
Aneta Rzewnicka, Rafał Dolot, Maciej Mikina, Jerzy Krysiak, Remigiusz Żurawiński   +4 more
doaj   +1 more source

A novel thermal and acidic approach to γ-keto sulfones synthesis from chalcones and sulfonyl hydrazide

Results in Chemistry
In this paper, a new synthetic method for the synthesis of γ-keto sulfones via the reaction of chalcones with sulfonyl hydrazide under thermal and acidic conditions was investigated.
Bahman Kafshgari, Sakineh Asghari, Ghasem Firouzzadeh Pasha, Hamidreza Younesi   +3 more
doaj   +1 more source

Synthesis of a Novel Amine‐Based Curing Agent for Epoxy Resins Derived From Vanillin

Journal of Applied Polymer Science, EarlyView.
The four‐step synthesis of a new bio‐based amine hardener is described starting from vanillin as a bio‐based compound. The hardener ADBA was utilized to cure DGEBA and the resulting Tg,tanδmax was determined via DMA. Compared to other bio‐based curing agents, our curing agent is obtainable in a high yield and leads to a superior Tg of 135°C.
Bastian Hahn, Gerd Wehnert, Elisabeth Schamel, Dominik Söthje   +3 more
wiley   +1 more source