Results 81 to 90 of about 12,336 (293)
Enantiospecific Cross-coupling of Cyclic Alkyl Sulfones
, 2023 Methods to form carbon-carbon bonds efficiently and with control of stereochemistry are critical for the construction of complex molecules. Cross-coupling reactions are among the most efficient and widely used reactions to construct molecules, with ...
Jana, Alpin +6 more
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A Facile and Mild Synthesis of Trisubstituted Allylic Sulfones from Morita-Baylis-Hillman Carbonates
Molecules, 2015 An efficient and catalyst-free synthesis of trisubstituted allylic sulfones through an allylic sulfonylation reaction of Morita-Baylis-Hillman (MBH) carbonates with sodium sulfinates has been developed.
Lin Jiang +5 more
doaj +1 more source
Angewandte Chemie, EarlyView.Die geminale Difunktionalisierung leicht verfügbarer Bausteine ermöglicht einen schnellen Zugang zu molekularer Komplexität. Diese Arbeit stellt eine Strategie vor, um zwei unterschiedliche funktionelle Gruppen an einem Carbonylkohlenstoff zu installieren, indem dieser in eine Donor–Donor‐Diazo‐Verbindung überführt wird. Die Methode ist sowohl im Batch‐
Vincent George +13 more
wiley +1 more source
Dipolar addition to cyclic vinyl sulfones leading to dual conformation tricycles
Beilstein Journal of Organic Chemistry, 2013 Dipolar addition of cyclic azomethine imines with cyclic vinyl sulfones gave rise to functionalized tricycles that exhibited fluxional behavior in solution at room temperature.
Steven S. Y. Wong +4 more
doaj +1 more source
, 2016 The hydrozirconation reaction of 1-alkynyl sulfoxides or sulfones with Cp2Zr(H)Cl in THF at room temperature predominantly gave Z-β-zirconated vinyl sulfoxides or sulfones with excellent regioselectivity.
Dehui Duan (2419603) +2 more
core +2 more sources
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Molecules, 2016 We reported herein the synthesis, antifungal activity, docking and in silico ADME prediction studies of four novel series of sulfones 6a–f, 8a–c, 10a–f and 12a–c.
Mohamed Fares +8 more
doaj +1 more source
Aziridinierung eines einzelnen Kohlenstoffatoms in Alkenen mittels Energietransferkatalyse
Angewandte Chemie, EarlyView.Im Gegensatz zur traditionellen Alken‐Aziridinierung über (formalen) Nitren‐Transfer berichten wir hier über eine Strategie zur intermolekularen Aziridinierung eines einzelnen Alken‐Kohlenstoffatoms bei zusätzlicher Funktionalisierung der anderen Position. Durch Energietransfer‐ (EnT‐)Katalyse werden Alkenylboronate und ‐silane in reaktive Intermediate
Fritz Paulus +7 more
wiley +1 more source
Vinyl sulfones: selective and tunable covalent warheads against challenging enzyme targets [PDF]
Exploration of Drug ScienceOver the past several decades there has been a growing recognition of the role that covalent drug candidates have played in the drug development process. With this recognition, compounds that are capable of selectively and irreversibly inactivating their
Ronald E. Viola
doaj +1 more source
Spatial structure of α-halogen-substituted sulfones [PDF]
, 1981 1. Conformational equilibrium between the gauche- and trans-forms is attained in α-halogenated sulfones with the gauche-form predominating. 2. The position of the aryl radical in α-haloaryl sulfones is close to interfering with.
Vereshchagin A. +2 more
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