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Loss of Beta-Cell Identity and Function as a Mechanism of Secondary Failure of Sulfonylurea Therapy in Diabetes. [PDF]
MedComm (2020)Patel S, Yan Z, Remedi MS.
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Association of Antidiabetic Medication Classes With Survival Outcomes in Pulmonary Hypertension Patients With Diabetes. [PDF]
Pulm CircTrammell AW +5 more
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A nomogram integrating machine learning with clinical predictors for osteosarcopenia risk prediction in type 2 diabetes mellitus. [PDF]
Front Endocrinol (Lausanne)Liang D, Zhan Z, Zhang Y, Yan S.
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Digenic HNF1A and ABCC8 variants provide mechanistic insight into early-onset diabetes.
J Clin Endocrinol MetabHonda M +8 more
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Sulfonylurea receptors and mechanism of sulfonylurea action
Experimental and Clinical Endocrinology & Diabetes, 2009Binding of hypoglycemic sulfonylureas and their analogues to the sulfonylurea receptor in the beta-cell plasma membrane mediates closure of the ATP-sensitive K+-channel (KATP-channel) and thereby stimulation of insulin release. The sulfonylurea receptor is a member of the traffic ATPase family with two intracellular nucleotide binding folds.
U, Panten +2 more
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The pharmacology of sulfonylureas
The American Journal of Medicine, 1981In this report we review the pharmacology of the hypoglycemic sulfonylurea drugs. The early work with sulfonylureas is briefly described. The pharmacokinetics of first-generation sulfonylureas, such as tolbutamide, chlorpropamide, acetohexamide and tolazamide, are described.
T G, Skillman, J M, Feldman
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Annual Review of Medicine, 1974
Sulfonylurea drugs such as tolbutamide have been used extensively in the treatment of patients with diabetes mellitus. The recent report of the University Group Dia betes Program (UGDP) (1) suggested an association of tolbutamide therapy with increased incidence of cardiovascular deaths.
G S, Levey, K C, Lasseter, R F, Palmer
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Sulfonylurea drugs such as tolbutamide have been used extensively in the treatment of patients with diabetes mellitus. The recent report of the University Group Dia betes Program (UGDP) (1) suggested an association of tolbutamide therapy with increased incidence of cardiovascular deaths.
G S, Levey, K C, Lasseter, R F, Palmer
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Endocrinology and Metabolism Clinics of North America, 1997
Sulfonylureas have been available for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) since the 1950s. With the introduction of new oral agents, there is a tendency to discount the value of sulfonylurea therapy. Sulfonylureas have the advantage of multiple formulations, low costs, minimal side effects, and demonstrated efficacy in ...
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Sulfonylureas have been available for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) since the 1950s. With the introduction of new oral agents, there is a tendency to discount the value of sulfonylurea therapy. Sulfonylureas have the advantage of multiple formulations, low costs, minimal side effects, and demonstrated efficacy in ...
openaire +2 more sources