Results 231 to 240 of about 24,524 (277)

Rational use of sulfonylureas

Postgraduate Medicine, 1992
The clinical use of sulfonylureas described in this article is both rational and effective for diabetic patients. Sulfonylureas are not used (1) in patients with insulin-dependent (type I) diabetes, because they are completely ineffective or (2) in patients with non-insulin-dependent (type II) diabetes who respond satisfactorily to diet, because they ...
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Sulfonylureas and platelet function

The American Journal of Medicine, 1981
The platelets of many patients with diabetes mellitus are abnormally sensitive to the effects of aggregatory agents in vitro. It has been proposed that this abnormal platelet function may play a role in the pathogenesis of vascular disease in diabetic subjects.
L J, Klaff, L, Kernoff, A I, Vinik, W P, Jackson, P, Jacobs   +4 more
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Novel Sulfonylurea and Non-sulfonylurea Drugs to Promote the Secretion of Insulin

Trends in Endocrinology & Metabolism, 2000
The onset of type 2 diabetes is characterized by two determining factors: the insufficient ability to secrete insulin and/or the resistance to its biological action. Although in a very small proportion of individuals, one of those two metabolic abnormalities is the leading cause of diabetes, in most subjects, the coexistence of both appears to be ...
R, Perfetti, A, Ahmad
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Clinical pharmacology of sulfonylureas

Metabolism, 1987
Sulfonylureas seem to have similar mechanisms of action, including an acceleration and increase of insulin secretion, an increase of the systemic availability of insulin, and probably indirectly, an increase of insulin action. Sulfonylureas may postpone the development of impaired glucose tolerance (IGT) to manifest non-insulin-dependent diabetes ...
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Hyperlipemia and Sulfonylurea Therapy

JAMA, 1964
To the Editor:— A report by Shipp et al ( JAMA 188: 468 [May 4] 1964), describing severe hyperlipemia in three diabetics treated with sulfonylurea compounds, proposes that "... enough control to prevent ketosis, but not enough to prevent hyperglycemia, may have provided a longterm metabolic balance favoring the development of hyperlipemia." It is ...
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Sulfonylurea Signal Transduction

1991
In the pancreatic beta cells the proximal step in sulfonylurea signal transduction is the binding of these clinically important drugs to high-affinity receptors in the beta cell membrane. Using HIT cells as a model system, we have established an extremely close correlation between the affinity of binding of glyburide and its analog, iodoglyburide, and ...
A E, Boyd, L, Aguilar-Bryan, J, Bryan, D L, Kunze, L, Moss, D A, Nelson, A S, Rajan, H, Raef, H D, Xiang, G C, Yaney   +9 more
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Management of sulfonylurea ingestions

Pediatric Emergency Care, 1999
In the majority of pediatric patients with an unintentional ingestion of a sulfonylurea, observation and, if necessary, intravenous glucose supplementation, are sufficient. However, with cases of persistent hypoglycemia or cases refractory to IV glucose supplementation, attempts to inhibit insulin secretion should be considered.
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Experiences in sulfonylurea therapy

Metabolism, 1973
Nine of our 14 patients, aged 2–16 yr with asymyptomatic hyperglycemia have been treated with oral sulfonylurea during the past 10 yr. Response has been variable. Only three showed definite improvement while on sulfonylurea. This improvement appeared to be associated with earlier peak insulin response rather than increased output of insulin.
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[Sulfonylurea].

Nihon rinsho. Japanese journal of clinical medicine, 2015
SU drug promotes insulin secretion by acting on pancreatic β cell. The hypoglycemic effect is the most powerful among oral diabetic drugs with high cost-effectiveness. Particularly for the Japanese with type 2 diabetes caused by a decrease in insulin secretion as a main pathological condition, it was widely used until the present since 1957 and largely
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Hyponatremia and Sulfonylureas

Diabetes Care, 1984
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