Results 31 to 40 of about 44,418 (298)

Association of high-sensitive C-reactive protein with advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus [PDF]

, 2006
Background: Type 2 diabetes mellitus is associated with increased cardiovascular risk. One laboratory marker for cardiovascular risk assessment is high-sensitivity C-reactive protein (hsCRP).
Balkau, Forst, Haffner, Haffner, Hedblad, Howard, Huupponen, Langenfeld, Maseri, Matthews, Morrow, Nissen, Paice, Pfützner, Pfützner, Pfützner, Pfützner, Pfützner, Pfützner, Pfützner, Ridker, Ridker, Ridker, Ridker, Ridker, Ridker, Riveline, Ross, Saito, Sellmayer, Serrano Rios, Simpson, Willerson, Yudkin   +33 more
core   +1 more source

MODY3 in the child with type 2 diabetes mellitus phenotype: case report

Сахарный диабет, 2013
MODY is a heterogeneous group of diseases that stem from certain genetic mutations and are characterized by beta-cell dysfunction, early clinical onset (before the age of 25) and autosomal dominant inheritance.
Tamara Leonidovna Kuraeva, Elena Alexandrovich Sechko, Irina Alexandrovna Eremina, O N Ivanova, Sergey Alexandrovich Prokof’ev   +4 more
doaj   +1 more source

Comparison of diabetes phenotype in children and their mothers with permanent neonatal diabetes mellitus carrying the same KCNJ11 variants

Endocrine Regulations, 2020
Objective. Mutations of the KCNJ11 gene are the most common cause of the permanent neonatal diabetes mellitus (PNDM). Majority of people with KNCJ11-PNDM have a de-novo mutation.
Stanik Juraj, Barak Lubomir, Dankovcikova Adriana, Valkovicova Terezia, Skopkova Martina, Gasperikova Daniela   +5 more
doaj   +1 more source

Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]

, 2017
ATP-sensitive potassium channels (K(ATP) channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, K(ATP) channels are essential for coupling glucose metabolism to insulin secretion.
Conway, Hannah, Emfinger, Christopher H., Moss, Jennifer B., Moss, Larry G., Nichols, Colin G., Remedi, Maria S., Wang, Yixi, Welscher, Alecia, Yan, Zihan   +8 more
core   +2 more sources

Effect of genetic polymorphisms on the development of secondary failure to sulfonylurea in Egyptian patients with type 2 diabetes

Therapeutic Advances in Endocrinology and Metabolism, 2011
Objective: This study investigated the possibility that genetic factors, such as polymorphism of K inward rectifier subunit (Kir6.2), E23K, and Arg 972 polymorphism of insulin receptor substrate-1 (IRS-1), may predispose patients to sulfonylurea failure.
Alaa E. El-sisi, Sahar K. Hegazy, Shereen S. Metwally, Alaa M. Wafa, Naglaa A. Dawood   +4 more
doaj   +1 more source

Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine [PDF]

, 2019
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control, it is often necessary to rely on combination therapy of multiple drugs or insulin because uncontrolled ...
Andreozzi, F, Mannino, Gc, Sesti, G
core   +1 more source

Assessing the environmental risks of sulfonylurea pollutants: Insights into the risk priority and structure-toxicity relationships

Ecotoxicology and Environmental Safety
Sulfonylureas are widely used herbicides globally; however, the health risks associated with exposure to these compounds are poorly understood. This study used fuzzy clustering to categorize 44 sulfonylurea compounds into three risk priority levels (I ...
Zhi-Cong He, Tao Zhang, Xin-Fang Lu, Rui Li, Wei Peng, Fei Ding   +5 more
doaj   +1 more source

Efeitos da adubação nitrogenada em cobertura sobre a seletividade de herbicidas à cultura do milho Effects of cover nitrogen fertilization on herbicide selectivity in corn

Planta Daninha, 2006
O objetivo deste trabalho foi avaliar os efeitos da adubação nitrogenada de cobertura sobre a seletividade dos herbicidas aplicados em pós-emergência na cultura do milho (Zea mays). Para isso, foram conduzidos dois experimentos.
M. Nicolai, R.F. López Ovejero, S.J.P. Carvalho, M.S. Moreira, P.J. Christoffoleti   +4 more
doaj   +1 more source

Severe hypoglycemia in users of sulfonylurea antidiabetic agents and antihyperlipidemics [PDF]

, 2016
Drug-drug interactions causing severe hypoglycemia due to antidiabetic drugs is a major clinical and public health problem. We assessed whether sulfonylurea use with a statin or fibrate was associated with severe hypoglycemia. We conducted cohort studies
Bilker, Warren B., Brensinger, Colleen M., Cardillo, Serena, Flockhart, David A., Flory, James H., Gagne, Joshua J., Han, Xu, Hennessy, Sean, Leonard, Charles E.   +8 more
core   +1 more source

Assessment of methyl 2-({[(4,6-dimethoxypyrimidin-2-yl)carbamoyl] sulfamoyl}methyl)benzoate through biotic and abiotic degradation modes

Open Chemistry, 2020
Detoxification and management of environmental contaminants is an exigent issue of current times. Sulfonylurea herbicide, Bensulfuron-methyl was investigated for its degradation demeanour in soils, through biotic and abiotic modes (biodegradation and ...
Gul Mahwash Mahar, Ahmad Khuram Shahzad
doaj   +1 more source